Significance of reduced uptake of iodinated fatty acid analogue for the evaluation of patients with acute chest pain

Kawai, Yuko; Tsukamoto, Eriko; Nozaki, Toshimitsu; Morita, Koichi; Sakurai, Minoru; Tamaki, Nagara

doi:10.1016/s0735-1097(01)01634-5

Cited by 123 publications

(81 citation statements)

References 26 publications

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“…Significant coronary stenosis was defined as ≧ 90% by visual assessment. In this study, we regarded the condition of patients as chronic stable angina when no evident attack has been observed for more than 2 weeks until 123 I-BMIPP-SPECT or 15 O-water PET.…”

Section: Study Populationmentioning

confidence: 99%

“…The spatial resolution was approximately 12 mm full-width at half-maximum (FWHM) after reconstruction [28,29]. 15 O-water PET All patients refrained from drinking caffeinated beverages for at least 24 hours before PET [30,31].…”

Section: I-bmipp-spectmentioning

confidence: 99%

“…Rest MBF and adenosine-induced hyperemic MBF were quantified by 15 O-water PET. The PET scanner was ECAT EXACT HR+ (Siemens/CTI).…”

Section: I-bmipp-spectmentioning

confidence: 99%

“…Reduced 123 I-BMIPP uptake has been reported in patients with ischemic heart disease [15][16][17][18][19][20][21][22][23][24]. In the diagnosis of chronic stable angina, stress myocardial perfusion scintigraphy is superior to 123 I-BMIPP scintigraphy [25].…”

Section: Introductionmentioning

confidence: 99%

“…In this study, 123 I-BMIPP uptake was compared with rest myocardial blood flow (MBF), hyperemic MBF and MFR assessed with 15 O-water positron emission tomography (PET). We investigated the relation of 123 I-BMIPP uptake to rest MBF, hyperemic MBF and MFR.…”

Section: Introductionmentioning

confidence: 99%

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Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina

Kageyama

Morita

Katoh

et al. 2005

Eur J Nucl Med Mol Imaging

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Long-chain fatty acid (LCFA) is the main energy source for normal myocardium at rest. In ischemic myocardium, the main energy substrate shifts from LCFA to glucose. 123 I-BMIPP is a radiolabeled LCFA analogue. In chronic stable angina without previous infarction, we suppose that reduced 123 I-BMIPP uptake is related to the substrate shift in myocardium with decreased myocardial flow reserve (MFR). Conclusion: In chronic stable angina without previous infarction, reduced 123 I-BMIPP uptake implies decreased MFR.

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Section: Study Populationmentioning

confidence: 99%

Section: I-bmipp-spectmentioning

confidence: 99%

“…Rest MBF and adenosine-induced hyperemic MBF were quantified by 15 O-water PET. The PET scanner was ECAT EXACT HR+ (Siemens/CTI).…”

Section: I-bmipp-spectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina

Kageyama

Morita

Katoh

et al. 2005

Eur J Nucl Med Mol Imaging

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Myocardial Metabolism in Health and Disease

Gropler

Peterson

Dilsizian

2010

Cardiac CT, PET and MR

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Molecular Imaging of the Heart

Boutagy

Fehér

Alkhalil

et al. 2019

Comprehensive Physiology

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Multimodality cardiovascular imaging is routinely used to assess cardiac function, structure, and physiological parameters to facilitate the diagnosis, characterization, and phenotyping of numerous cardiovascular diseases (CVD), as well as allows for risk stratification and guidance in medical therapy decision‐making. Although useful, these imaging strategies are unable to assess the underlying cellular and molecular processes that modulate pathophysiological changes. Over the last decade, there have been great advancements in imaging instrumentation and technology that have been paralleled by breakthroughs in probe development and image analysis. These advancements have been merged with discoveries in cellular/molecular cardiovascular biology to burgeon the field of cardiovascular molecular imaging. Cardiovascular molecular imaging aims to noninvasively detect and characterize underlying disease processes to facilitate early diagnosis, improve prognostication, and guide targeted therapy across the continuum of CVD. The most‐widely used approaches for preclinical and clinical molecular imaging include radiotracers that allow for high‐sensitivity in vivo detection and quantification of molecular processes with single photon emission computed tomography and positron emission tomography. This review will describe multimodality molecular imaging instrumentation along with established and novel molecular imaging targets and probes. We will highlight how molecular imaging has provided valuable insights in determining the underlying fundamental biology of a wide variety of CVDs, including: myocardial infarction, cardiac arrhythmias, and nonischemic and ischemic heart failure with reduced and preserved ejection fraction. In addition, the potential of molecular imaging to assist in the characterization and risk stratification of systemic diseases, such as amyloidosis and sarcoidosis will be discussed. © 2019 American Physiological Society. Compr Physiol 9:477‐533, 2019.

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Significance of reduced uptake of iodinated fatty acid analogue for the evaluation of patients with acute chest pain

Abstract: These data indicate that BMIPP SPECT may specifically identify previous ischemic lesions due to coronary stenosis or spasm in patients with acute chest pain.

Cited by 123 publications

References 26 publications

Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina

Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina

Myocardial Metabolism in Health and Disease

Molecular Imaging of the Heart

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