Significance of pulse pressure variability in predicting functional outcome in acute ischemic stroke: a retrospective, single-center, observational cohort study

Abstract

This study aimed to determine the association between pulse pressure variability (PPV) and short- and long-term outcomes of acute ischemic stroke (AIS) patients. We studied 203 tertiary stroke center patients with AIS. PPV during 72 h after admission was analyzed using different variability parameters including standard deviation (SD). Patients’ outcome was assessed after 30 and 90 days post-stroke with modified Rankin Scale. The association between PPV and outcome was investigated using logistic regression analysis with adjustment for potential confounders. The predictive significance of PPV parameters was determined using area under the curve (AUC) of receiver operating characteristics. In the unadjusted logistic regression analysis, all PPV indicators were independently associated with unfavorable outcome at 30 days (i.a. Odds ratio (OR) = 4.817, 95%CI 2.283–10.162 per 10 mmHg increase in SD, p = 0.000) and 90 days (i.a. OR = 4.248, 95%CI 2.044–8.831 per 10 mmHg increase in SD, p = 0.000). After adjustment for confounders, ORs for all PPV indicators remained statistically significant. On the basis of AUC values, all PPV parameters were found relevant outcome predictors (p < 0.01). In conclusion, elevated PPV during first 72 h after admission due to AIS is associated with unfavorable outcome at 30 and 90 days, independent of mean blood pressure levels.

Higher long-term visit-to-visit blood pressure variability is associated with severe cerebral small vessel disease in the general population

“…Previous studies evaluated BPV most frequently using SBP or DBP, few studies employed PP. So far, studies have reported that PP was a better predictor of cardiovascular 27 and cerebrovascular 28 risk than diastolic or systolic pressure. Studies showed PP was associated with the cognitive independence of SBP 29,30 .…”

Brain injury mobile diagnostic system: Applications in civilian medical service and on the battlefield—General concept and medical aspects

“…As noted above, to obtain as much information as possible, the device will be equipped with various types of miniaturized portable diagnostic devices (sensors), used in military operations 18 for the assessment of: Peripheral blood oxygen saturation (SpO 2 ) Heart rate Blood pressure, including systolic, diastolic, mean, and especially pulse pressure 19 Body temperature ECG Capnography …”

“…• Heart rate • Blood pressure, including systolic, diastolic, mean, and especially pulse pressure 19 • Body temperature…”