Significance of Preoperative Systemic Inflammation Score in Short‐Term and Long‐Term Outcomes of Patients with Pathological T2–4 Gastric Cancer After Radical Gastrectomy

Sato, Bummei; Kanda, Mitsuro; Tanaka, Chie; Kobayashi, Daisuke; Iwata, Nakao; Hattori, Norifumi; Suenaga, Masaya; Hayashi, Masamichi; Yamada, Suguru; Murotani, Kenta; Fujiwara, Michitaka; Kodera, Yasuhiro

doi:10.1007/s00268-018-4597-7

Cited by 29 publications

(34 citation statements)

References 45 publications

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“…Recently, Sato et al also found that SIS can predict the survival in a small cohort of patients with pT2-4 GC after radical gastrectomy, and they found that the SIS was not an independent prognostic factor, [32] this finding was consistent with the current study. Compared with the study of Sato, our study has the following advantages.…”

Section: Discussionsupporting

confidence: 92%

Prognostic importance of the preoperative modified systemic inflammation score for patients with gastric cancer

Lin

Xie

et al. 2018

Gastric Cancer

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Section: Discussionsupporting

confidence: 92%

Prognostic importance of the preoperative modified systemic inflammation score for patients with gastric cancer

Lin

Xie

et al. 2018

Gastric Cancer

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“…An additional explanation could be that delayed administration after 8 weeks was associated with several factors that are related to hematogenous recurrence. Age, total gastrectomy, disease stage, and postoperative complications are reported to correlate with malnutrition and pro-inflammatory status, and poor status of these is related to hematogenous recurrence of gastric cancer [22]. In our study, most of these factors also caused a delay in the initiation of S-1 monotherapy.…”

Section: Discussionmentioning

confidence: 49%

Delay in initiation of postoperative adjuvant chemotherapy with S-1 monotherapy and prognosis for gastric cancer patients: analysis of a multi-institutional dataset

et al. 2019

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Background This study aimed to evaluate whether the timing of initiating postoperative chemotherapy with S-1 monotherapy affects gastric cancer patients' prognosis. Methods A multi-institution dataset identified patients with pStage II or III gastric cancer who received S-1 monotherapy for over 6 months after curative resection between 2010 and 2014. Patients were divided into three groups based on the timing of S-1 monotherapy initiation. Prognostic factors for relapse-free survival (RFS) were investigated. Results We classified 401 patients into groups as follows: S-1 administered within 6 weeks (n = 247), between 6 and 8 weeks (n = 95), and after 8 weeks (n = 59). The RFS times were not significantly different in the within 6 weeks group and the between 6 and 8 weeks group, but the after 8 weeks group had a shorter RFS time compared with the other two groups (within 6 weeks group vs. after 8 weeks group; P = 0.0044). By disease stage, this trend was the same. The multivariable analysis showed that a larger tumor size (≥ 50 mm), pStage III, and the after 8 weeks group were independent prognostic factors for RFS (after 8 weeks group: hazard ratio, 2.05; P = 0.0069). The prevalence of hematogenous metastasis as the initial recurrence site increased by delayed initiation of S-1. A forest plot revealed that delayed administration after 8 weeks was associated with a greater risk of recurrence in most subgroups. Conclusions Postoperative chemotherapy with S-1 monotherapy for gastric cancer is recommended to begin within 8 weeks after surgery.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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“…SIS is based on the serum albumin level and the lymphocyte-to-monocyte ratio and is scored simply as 0, 1, and 2 [50]. Sato et al investigated the relationship between preoperative SIS and postoperative complications in 187 previously untreated patients who underwent gastrectomy for pT2-4 gastric cancer and found a significant positive association between the SIS score and the incidence of complications [51]. One explanation for this is that a decreased lymphocyte count can compromise antimicrobial immune responses, contributing to increased infection with bacteria and other potential pathogens [50,52].…”

Section: Inflammationmentioning

confidence: 99%

Preoperative predictors of postoperative complications after gastric cancer resection

Kanda¹

2019

Surg Today

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Risk management is becoming an increasingly important healthcare issue. Gastrectomy with lymphadenectomy is still the mainstay of treatment for localized gastric cancer, but it is sometimes associated with postoperative complications that compromise the patient's quality of life, tolerability of adjuvant treatment, and prognosis. Parameters based exclusively on preoperative factors can identify patients most at risk of postoperative complications, whereby surgeons can provide the patient with precise informed consent information and optimal perioperative management. Ultimately, these predictive tools can also help minimize medical costs. In this context, many studies have identified factors that predict postoperative complications, including indicators based on body constitution, nutrition, inflammation, organ function and hypercoagulation. This review presents our current understanding and discusses some future perspectives of preoperatively identified factors predictive of complications after resection for gastric cancer.

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Significance of Preoperative Systemic Inflammation Score in Short‐Term and Long‐Term Outcomes of Patients with Pathological T2–4 Gastric Cancer After Radical Gastrectomy

Abstract: SIS represents a simple predictor for incidence of postoperative complications and survival in patients with pT2-4 GC.

Cited by 29 publications

References 45 publications

Prognostic importance of the preoperative modified systemic inflammation score for patients with gastric cancer

Prognostic importance of the preoperative modified systemic inflammation score for patients with gastric cancer

Delay in initiation of postoperative adjuvant chemotherapy with S-1 monotherapy and prognosis for gastric cancer patients: analysis of a multi-institutional dataset

Preoperative predictors of postoperative complications after gastric cancer resection

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