Significance of preoperative blood tests in the prognosis of colorectal cancer: A prospective, multicenter study from Hungary

Biró, Adrienn; Kolozsi, Péter; Nagy, Attila; Varga, Zsolt; Káposztás, Zsolt; Tóth, Dezső

doi:10.1002/jcla.24128

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…The immune cell counts, inflammatory and coagulation parameters and their ratios were examined for a prognostic factor of cancer. In a recent study, the neutrophil-lymphocyte ratio was proved to be an independent prognostic factor for disease-free survival in patients with non-metastatic colon cancer ( 19 ). In another study, Zhang at al.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients

Ömeroğlu

Gülmez²,

Uzun³

et al. 2023

Front. Oncol.

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BackgroundThe metastatic lymph nodes (MLN) are interpreted to be correlated with prognosis of the colorectal cancers (CRC). The present retrospective study aimed to investigate the clinical significance of the largest MLN size in terms of postoperative outcomes and its predictive value in the prognosis of the patients with stage III CRC.MethodsBetween May 2013 and December 2018, a total of 101 patients who underwent curative resection for stage III CRC retrospectively reviewed. All patients were divided into two groups regarding cut-off value (<1.05 cm and ≥1.05 cm) of maximum MLN diameter measured histopathologically. A comparative analysis of demographic and clinicopathological characteristics of the patients and their postoperative outcomes were performed.ResultsTwo groups carried similar demographic data and preoperative laboratory variables except the lymphocyte count, hematocrit (HCT) ratio, hemoglobin level and mean corpuscular volume (MCV) value (p<0.05). The patients with MLN diameter ≥1.05 cm (n=46) needed more erythrocyte suspension and were hospitalized longer than the patients with a diameter <1.05 cm (n=55) (p=0.006 and 0.0294, respectively). Patients with MLN diameter < 1.05 cm had a significantly longer overall survival than patients with MLN diameter ≥ 1.05 cm (75,29 vs. 52,57 months, respectively). Regarding the histopathologic features, the patients with MLN diameter ≥1.05 cm had larger tumor size and higher number of MLN than those with diameter <1.05 cm (p=0.049 and 0.001).ConclusionThe size of MLN larger than 1.05 cm may be predictive for a poor prognosis and lower survival of stage III CRC patients. The largest MLN size may be a proper alternative factor to the number of MLNs in predicting prognosis or in staging CRC patients.

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Section: Discussionmentioning

confidence: 99%

Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients

Ömeroğlu

Gülmez²,

Uzun³

et al. 2023

Front. Oncol.

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“…Furthermore, although the median time between hematology and amputation was only six days, we included dogs for which hematology was performed up to 21 days prior to amputation, and hematological parameters may have changed during this time. There is no standard to define the “pre-operative” period, and this time varies across veterinary and human studies, sometimes reaching up to 60 days in veterinary [ 9 , 12 ] and 30 days in human studies [ 57 , 58 ]. Furthermore, although most dogs were staged thoroughly, some dogs might have suffered from unidentified diseases, causing alterations in their hematological parameters.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Role of Preoperative Hematological and Inflammatory Indices in Canine Appendicular Osteosarcoma

Rigas,

Tanis,

Morello

et al. 2023

Veterinary Sciences

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Hematological indices play a prognostic role in human osteosarcoma (OSA), but data are limited in dogs. The aim of this retrospective multicentric cohort study was to investigate the prognostic significance of pre-operative hematological/inflammatory indices in a cohort of client-owned dogs with appendicular OSA receiving standardized treatment. Cut-offs associated with progression-free survival (PFS) for pre-operative hematological values/ratios were established using the minimal p-value approach. Historical prognostic factors were also assessed. Statistical analyses were performed for the whole population and after the exclusion of sighthounds. Fifty-nine dogs were included (13 were sighthounds). Multivariable analysis revealed that a low neutrophil count (<4.37 × 109/L, HR0.28, CI 95% 0.13–0.61, p = 0.001), a high red blood cell count (≥7.91, HR3.5, CI 95% 1.56–7.9, p = 0.002), and a proximal humerus location (HR3.0, CI 95% 1.48–6.1, p = 0.002) were associated with shorter PFS. In the sighthound-only population, only OSA location was significantly associated with PFS in univariable analysis. When sighthounds were excluded, a low neutrophil count, a low monocyte count, and a proximal humerus location were associated with shorter PFS, in multivariable analysis. Neutrophil count and possibly monocyte and red blood cell counts can be useful prognostic markers in canine OSA treated with amputation and adjuvant carboplatin. However, not all indices are appropriate in sighthounds.

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“…As with other cancers, a higher NLR is strongly associated with shorter survival in cholangiocarcinoma [111]. B. Dapsone in colon adenocarcinoma: Specifically in colon adenocarcinoma, a higher NLR is associated with shorter survival, while a low NLR is associated with longer survival [112][113][114]. Bevacizumab, a pharmaceutical monoclonal antibody to vascular endothelial growth factor (VEGF), is often used in the treatment of colon adenocarcinoma and NSCLC.…”

Section: Dapsonementioning

confidence: 99%

MDACT: A New Principle of Adjunctive Cancer Treatment Using Combinations of Multiple Repurposed Drugs, with an Example Regimen

Kast¹,

Alfieri

Assi

et al. 2022

Cancers

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In part one of this two-part paper, we present eight principles that we believe must be considered for more effective treatment of the currently incurable cancers. These are addressed by multidrug adjunctive cancer treatment (MDACT), which uses multiple repurposed non-oncology drugs, not primarily to kill malignant cells, but rather to reduce the malignant cells’ growth drives. Previous multidrug regimens have used MDACT principles, e.g., the CUSP9v3 glioblastoma treatment. MDACT is an amalgam of (1) the principle that to be effective in stopping a chain of events leading to an undesired outcome, one must break more than one link; (2) the principle of Palmer et al. of achieving fractional cancer cell killing via multiple drugs with independent mechanisms of action; (3) the principle of shaping versus decisive operations, both being required for successful cancer treatment; (4) an idea adapted from Chow et al., of using multiple cytotoxic medicines at low doses; (5) the idea behind CUSP9v3, using many non-oncology CNS-penetrant drugs from general medical practice, repurposed to block tumor survival paths; (6) the concept from chess that every move creates weaknesses and strengths; (7) the principle of mass—by adding force to a given effort, the chances of achieving the goal increase; and (8) the principle of blocking parallel signaling pathways. Part two gives an example MDACT regimen, gMDACT, which uses six repurposed drugs—celecoxib, dapsone, disulfiram, itraconazole, pyrimethamine, and telmisartan—to interfere with growth-driving elements common to cholangiocarcinoma, colon adenocarcinoma, glioblastoma, and non-small-cell lung cancer. gMDACT is another example of—not a replacement for—previous multidrug regimens already in clinical use, such as CUSP9v3. MDACT regimens are designed as adjuvants to be used with cytotoxic drugs.

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Significance of preoperative blood tests in the prognosis of colorectal cancer: A prospective, multicenter study from Hungary

Cited by 7 publications

References 34 publications

Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients

Clinical significance of the histopathological metastatic largest lymph node size in colorectal cancer patients

The Prognostic Role of Preoperative Hematological and Inflammatory Indices in Canine Appendicular Osteosarcoma

MDACT: A New Principle of Adjunctive Cancer Treatment Using Combinations of Multiple Repurposed Drugs, with an Example Regimen

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