Significance of Platelet Count in the Outcomes of Hepatectomized Patients with Hepatocellular Carcinoma Exceeding the Milan Criteria

Amano, Hodaka; Tashiro, Hirotaka; Oshita, Akihiko; Kobayashi, Tsuyoshi; Tanimoto, Yoshisato; Kuroda, Satoshi; Tazawa, Hirofumi; Itamoto, Toshiyuki; Asahara, Toshimasa; Ohdan, Hideki

doi:10.1007/s11605-011-1538-2

Cited by 26 publications

(21 citation statements)

References 29 publications

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“…However, few studies have focused on the influence of PLT on postoperative recurrence. Although Amano et al [45] showed that decreased PLT was associated with a higher risk of recurrence in HCC, our study indicated that patients with a PLT level ≥ 148 × 10 9 /L had a higher recurrence probability. As prognosis of HCC remains far from satisfactory owing to the high incidence of tumor recurrence, several HCC prognostic models (such as CLIP [48][49][50][51] ) have been proposed.…”

Section: Discussioncontrasting

confidence: 86%

“…First and most important, although there was an adverse relationship between PLT and plateletbased indices, high levels of all predicted a high HCC recurrence. This dichotomy may due to the fact that although thrombocytopenia/low PLT has been identified as a crucial risk factor for HCC formation [10,11] and prognosis [44][45][46][47] , it was identified as a favorable factor for HCC prognosis in our study and several others [42,43] . In addition, our limited study population included numerous variables that may have contributed to the discrepancy.…”

Section: A B C D E Fmentioning

confidence: 59%

“…Nouso et al [43] recruited 157 HCC patients with Child-Pugh class C cirrhosis and found that a PLT level > 80 × 10 9 /L was an independent predictor of poor overall survival. In contrast, additional studies highlighted that thrombocytopenia/low PLT level adversely affected survival in HCC patients who received liver resection [44][45][46][47] . However, few studies have focused on the influence of PLT on postoperative recurrence.…”

Section: Discussionmentioning

confidence: 99%

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Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence

Pang

Zhang

et al. 2015

WJG

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Section: Discussioncontrasting

confidence: 86%

Section: A B C D E Fmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence

Pang

Zhang

et al. 2015

WJG

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“…Prognosis is limited when it presents at advanced stage, as is frequent. Thrombocytopenia associated with liver fibrosis has been suggested as a cirrhosis surrogate (7), to be potentially useful in screening for patients at risk of HCC (8) and for prognosis (9–11). In this study, we compared several clinical parameters of patients with small and larger HCCs and report that different parameter patterns could be discerned.…”

Section: Introductionmentioning

confidence: 99%

Platelet-Related Phenotypic Patterns in Hepatocellular Carcinoma Patients

Carr

Lin

2014

Seminars in Oncology

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Background Small HCCs usually arise in cirrhosis, often with associated thrombocytopenia. Many large HCC patients have normal blood platelet counts. Aims To compare parameter and phenotype patterns of patients with small ≤3cm and larger HCCs. Methods Retrospective analysis was undertaken of a 4139 patient HCC database to compare patient demographics, liver and tumor characteristics associated with small and large size HCCs, especially with respect to platelet counts. Results Patients with larger HCCs had more tumor nodules and PVT positivity, and had higher blood AFP, bilirubin and platelet counts. In patients with larger tumors and normal platelets (43.7% of the cohort), tumors were larger and AFP levels were higher, with lower bilirubin and AST levels than in patients with larger tumors and thrombocytopenia (17.5%). A parsimonious multinomial regression model showed high Odds Ratio for AFP and platelets for tumors >3cm with PVT. Conclusions Platelet levels are associated with distinct large HCC phenotypes.

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“…Unfortunately, evaluating molecular markers requires extra time and effort, as well as increased cost. Therefore, routine laboratory assessments, including γ-glutamyl transpeptidase (GGT) (7), monocyte count (8), platelet count (9) and neutrophil-to-lymphocyte ratio (10) have been developed to be predictive factors for survival in HCC.…”

Section: Introductionmentioning

confidence: 99%

Preoperative mean corpuscular hemoglobin affecting long-term outcomes of hepatectomized patients with hepatocellular carcinoma

Huang

Liu

et al. 2015

Molecular and Clinical Oncology

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Abstract. Pretreatment anemia has been reported to be associated with survival in several solid tumor types. In terms of survival, only limited data on the hemoglobin (HGB) level in hepatocellular carcinoma (HCC) have been published and no data on mean corpuscular hemoglobin (MCH) level in HCC is available. The present study sought to examine the role of HGB and MCH levels in predicting long-term survival of patients with HCC who undergo resection. A retrospective study of 399 consecutive patients (1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994) who underwent hepatic resection for HCC in Sun Yat-Sen University Cancer Centre was performed. Serum HGB and MCH levels were examined preoperatively, and their prognostic capabilities were evaluated by Cox's proportional hazard model. Among the whole cohort, the HGB level appeared to be positively correlated with the MCH level (P<0.001). Survival analysis revealed that low levels of HGB (P=0.007) and MCH (P<0.001) were correlated with shorter overall survival (OS). Multivariate analysis revealed that MCH level was independently associated with OS (P<0.001), however, not HGB (P=0.278). In addition, 129 patients with large HCC (≥10 cm) tended to have a poorer OS (P<0.001) when compared with patients with smaller HCC. On subanalysis of patients with large HCC, MCH level also retained its stratified significance (P=0.001). Along with common clinicopathological variables, these results suggested that MCH, however, not HGB, may be useful in assessing prognosis for patients with HCC who undergo hepatectomy, particularly in identifying patients with large HCC who are most likely benefit from resection.

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Significance of Platelet Count in the Outcomes of Hepatectomized Patients with Hepatocellular Carcinoma Exceeding the Milan Criteria

Abstract: Hepatectomy for patients with advanced HCC exceeding MC improves survival, especially for patients with a sufficiently high platelet count, although recurrence rates after initial hepatectomy are high.

Cited by 26 publications

References 29 publications

Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence

Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence

Platelet-Related Phenotypic Patterns in Hepatocellular Carcinoma Patients

Preoperative mean corpuscular hemoglobin affecting long-term outcomes of hepatectomized patients with hepatocellular carcinoma

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