Significance of plasma protein abnormalities in dogs and cats

McGrotty, Yvonne; Knottenbelt, Clare

doi:10.1136/inpract.24.9.512

Cited by 13 publications

(13 citation statements)

References 2 publications

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“…The easy determination of the serum Glb concentrations may contribute to the detection of an inflammatory process because Glb are positive APPs (37,9,13,14,11,41,38). This parameter significantly increases in the infected rabbits at the 7 th day.…”

Section: Discussionmentioning

confidence: 99%

“…Changes in serum protein concentrations result in a variety of clinical signs and systemic effects and are associated with a number of disease processes and synthesis of approximately 40 acute phase proteins (APPs), such as α 1 -antitrypsin, α 1 -acid glycoprotein, haptoglobin, α 2 -macroglobin, ceruloplasmin, transferrin, fibrinogen, C-reactive protein, serum amyloid A, tumour necrosis factors (11), and etc. The concentrations of these plasma proteins often increase (positive APPs) and more rarely decrease (negative APPs) during the acute phase response to inflammation or infection.…”

Section: Introductionmentioning

confidence: 99%

“…9, 13, 14, 15), and their expression represents effector mechanisms of innate immunity (16,17). These remarkable APPs have been extensively studied in humans and in laboratory animals (18,11,19).…”

Section: Introductionmentioning

confidence: 99%

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Study on the total proteins and main protein fractions in rabbits experimentally infected with Staphylococcus aureus

Georgieva¹,

Petrov²,

Georgiev³

et al. 2017

TJS

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Infections with Staphylococcus aureus are a common cause which can induce severe skin infections in rabbits leading to important economic losses. The present study was conducted to evaluate the changes in the concentrations of total protein, albumin, globulin, fibrinogen, and albumin/globulin ratio during S. aureus infection using a model for experimental infection of rabbits. The experiment was carried out on 13 rabbits at the age of 3 months. Infection was induced by inoculation of 7 rabbits by100 μL of bacterial suspension of a field S. aureus strain (density: 8х10 8 cfu/mL) and 6 other rabbits were not treated (controls). Blood samples for principal protein analysis were collected before (0 h) and at 24, 48 and72 h on day 7, 14, and 21 after infection. Total protein level showed little changes in the experimental group. The concentration of albumin decreased in the experimental group since 32.2±2.30 g/L to 27.3±1.9g/L. The serum level of globulins rose significantly (P<0.05) in the experimental group and slightly in the control group. Albumin/globulin ratio was lowered and significantly different on day 4 (P<0.01) and on day 7 (P<0.001). The concentration of fibrinogen was used as an acute phase protein with aim to confirm the incidence of infection. In parallel, rectal temperature and skin lesions (abscesses) were recorded. In all infected animals, formation of abscess due to the proliferation of the inoculated strain was observed within 48-96 h following the bacterial inoculation and these lesions have gradually extended leading to purulent exudates several days after and sometimes to secondary abscesses in surrounding muscles.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Study on the total proteins and main protein fractions in rabbits experimentally infected with Staphylococcus aureus

Georgieva¹,

Petrov²,

Georgiev³

et al. 2017

TJS

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“…Protein electrophoresis is also an important laboratory technique for the evaluation of serum protein abnormalities in dogs and cats (McGrotty and Knottenbelt 2002). Using agarose gel electrophoresis Abate et al (2000) determined six fractions in healthy dogs: albumin, α 1 -, α 2 -, β 1 -, β 2 -, and γ-globulins.…”

Section: Normal Serum Protein Patternmentioning

confidence: 99%

Serum proteins and their diagnostic utility in veterinary medicine: a review

Tóthová¹,

Nagy²,

Kováč³

2016

Vet. Med.

130

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ABSTRACT:The evaluation of serum proteins and their electrophoretic pattern is a well-established laboratory method in the diagnosis of many diseases in humans, which has replaced the biochemical determination of the concentrations of albumin and the ratio of albumin to globulins. The measurement of serum proteins may be an important diagnostic tool for the detection, diagnosis, and monitoring of various diseases and pathological processes. The results of serum protein electrophoresis can be one of the most useful diagnostic aids in a wide spectrum of diseases, including infectious and inflammatory diseases, renal or gastrointestinal disorders, immunodeficiency states, as well as paraproteinaemias caused by lymphoid or plasma cell neoplasia. Although many studies have been carried out to determine the usefulness of the determination of serum proteins and their electrophoretic pattern in various disease conditions and disorders also in animals, serum protein evaluation is still a relatively little-used diagnostic tool in veterinary medicine. In this article, methods of serum protein determination, their diagnostic utility in animal care practice and their different patterns in dysproteinaemias and paraproteinaemias are reviewed.

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“…A large number of studies, which refers to analysis of biochemical profile during urinary infections, are based on the analysis of proteins. Changes in the concentrations of blood proteins are the result of various clinical symptoms and are associated with pathophysiological processes and synthesis of acute-phase proteins (McGrotty & Knottenbelt, 2002).…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Biochemical Parameters During Urinary Infection in Maltese and Belgian Shepherd Dogs

Fočak¹,

Hasković²,

Suljević³

et al. 2017

Cercetari Agronomice in Moldova

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ABSTRACT. Urinary tract infections can be uncomfortable, painful and even dangerous for most dog breeds. Clinical signs are often nonspecific and insufficient for diagnosis. Urinalysis in combination with biochemical parameters and urine culture is the best combination of clinical findings for diagnosis of urinary tract infections. The incidence of urinary tract infections in dogs population is growing and 27% of dogs develop an urinary tract infection through their life. Urinary infections occur more often in the elderly than in younger dogs. More than 70% of all urinary tract infections are infections with one bacterial species. Biochemical profile is important aspect for diagnosis establishment, but due to the nature of action infection by different agents may be considered as individual case. The main aim of this research was to analyse biochemical parameters of Maltese and Belgian Shepherd (Malinois) dog breed, who were affected by urinary tract infections. Urea concentration was elevated in Malinois, while urea, phosphates, albumins and alkaline phosphatase activity were elevated in Maltese dogs. Statistical analysis showed differences in concentrations of urea, creatinine, phosphates, so as alanine aminotransferase, alkaline phosphatase and amylase activity between compared breeds during acute urinary infections. Maltese dogs are less resistant to bacterias, that causes urinary tract infections, and have lower chance to maintain homeostasis of biochemical parameters in blood during urinary bacterial infections, in comparison to Maltese dogs.

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Significance of plasma protein abnormalities in dogs and cats

Cited by 13 publications

References 2 publications

Study on the total proteins and main protein fractions in rabbits experimentally infected with Staphylococcus aureus

Study on the total proteins and main protein fractions in rabbits experimentally infected with Staphylococcus aureus

Serum proteins and their diagnostic utility in veterinary medicine: a review

Comparative Evaluation of Biochemical Parameters During Urinary Infection in Maltese and Belgian Shepherd Dogs

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