Significance of P-glycoprotein, p53, and survivin expression in renal cell carcinoma

Baytekin, Firat; Tuna, Burçin; Mungan, Uğur; Aslan, Güven; Yörükoğlu, Kutsal

doi:10.1016/j.urolonc.2009.09.001

Cited by 30 publications

(26 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Baytekin et al did not observe a correlation between p53 and histopathological type; however, an inverse correlation was found between p53 expression and tumor stage (p = 0.014) and the Fuhrman nuclear grade (p = 0.04) in RCC [29].…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: a microarray study

Erdem¹,

Oktay²,

Yıldırım³

et al. 2013

pjp

View full text Add to dashboard Cite

The aim of this study was to investigate the relationship of AEG-1 and p53 with the prognostic parameters of renal cell carcinoma (RCC). In this study, 50 paraffin blocks were histopathologically diagnosed at the Department of Pathology of the Medical Hospital of Duzce University, between 2005 and 2011. The cases consisted of 24 clear cell (CC) and 26 non-clear cell (NCC) RCC subtypes as follows: 24 (48%) clear cell RCC, 12 (24%) papillary RCC, 4 (8%) multilocular cystic RCC and 10 (20%) chromophobe RCC; none had sarcomatoid changes. By immunohistochemical analysis we investigated AEG-1 and p53 expression in carcinomas of the kidney, and by statistical analysis determined their relationship with clinicopathological parameters. Significant relationships were found between increasing tumor diameter and the increase of p53 (p = 0.028). In addition, p53 was significantly related to renal sinus invasion (p = 0.05) and Fuhrman grade (p = 0.026). There was a significant relationship between increased AEG-1 staining scores and CC and NCC carcinoma subtypes (p = 0.032), tumor capsule invasion (p = 0.01) and lymphovascular invasion (p = 0.015). There was also a significant correlation between tumor size and capsule and lymphovascular invasion (p = 0.02). We concluded that high AEG-1 and p53 expression correlates with the prognostic parameters in RCC patients, and in addition may be associated with tumor progression.

show abstract

Section: Discussionmentioning

confidence: 92%

“…Although the ability of p53 to induce apoptosis is known, its prognostic significance for RCC remains controversial [24][25][26][27][28][29]. Sejima et al have shown the alteration of apoptotic-regulatory molecule expression during carcinogenesis by comparing tumoral expression with that of normal tissue.…”

Section: Discussionmentioning

confidence: 99%

Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: a microarray study

Erdem¹,

Oktay²,

Yıldırım³

et al. 2013

pjp

View full text Add to dashboard Cite

show abstract

“…Most of these abnormalities have a direct or indirect effect on p53. The loss of p53 or other protein functions in CML evolution decreases the expression of natural inhibitors of survivin (30)(31)(32). Indeed, the higher Smac/DIABLO expression in the same high/intermediate Sokal group compared to low Sokal group (p=0.009), suggests a compensatory mechanism in favor of apoptosis activation.…”

Section: Discussionmentioning

confidence: 99%

Survivin and P-glycoprotein are associated and highly expressed in late phase chronic myeloid leukemia

Maia¹

2011

Oncol Rep

View full text Add to dashboard Cite

Abstract. resistance to tyrosine-kinase inhibitors is a serious problem in the treatment of chronic myeloid leukemia (cMl). Using Western blot, real-time qRT-PCR and flow cytometry, we investigated the expression of survivin, Smac/DIABLO and P-glycoprotein (Pgp) in patients with CML. Survivin overexpression has been associated with cancer progression, multidrug resistance, poor prognosis and short survival in several types of neoplasms including hematological malignancies. In this work, survivin expression was significantly elevated in late, in contrast to early, chronic phase CML (p=0.044). Patients with high or intermediate prognostic Sokal score presented higher survivin levels (p=0.012), as well as Smac/DIABLO levels (p=0.009) compared to low Sokal score. The strong correlation between survivin and Pgp expression in late (p=0.018), but not in early (p=0.5) chronic phase of cMl, suggests that this association may play a biological role in late cMl phase and may offer an important target for the development of new therapies.

show abstract

“…Overexpression of survivin has been linked to adverse tumor features and poor prognosis [57,58]. B7-H1, a cell surface glycoprotein that participates in T-cell costimulation, is a another marker of interest that was independently correlated with a greater risk for RCC death [59].…”

Section: Prognostication/predicting Response To Therapymentioning

confidence: 99%

Tumor Biology and Prognostic Factors in Renal Cell Carcinoma

2011

View full text Add to dashboard Cite

In the past 15 years, there has been an increased understanding of the tumor biology of renal cell carcinoma (RCC). The identification of vascular endothelial growth factor (VEGF), its related receptor (VEGFR), and the mammalian target of rapamycin as dysregulated signaling pathways in the development and progression of RCC has resulted in the rational development of pharmaceutical agents capable of specifically targeting key steps in these pathways. Clinical trials have demonstrated survival benefit with these agents, particularly in clear cell RCC patients. However, metastatic RCC will progress in all patients, resulting in a critical need to determine patient risk and optimize treatment. The goal of this article is to highlight the significant breakthroughs made in understanding the critical genetic alterations and signaling pathways underlying the pathogenesis of RCC. The discovery of prognostic factors and development of comprehensive nomograms to stratify patient risk and predictive biomarkers to facilitate individualized treatment selection and predict patient response to therapy also are reviewed. The Oncologist 2011;16(suppl 2):4 -13

show abstract

Significance of P-glycoprotein, p53, and survivin expression in renal cell carcinoma

Cited by 30 publications

References 24 publications

Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: a microarray study

Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: a microarray study

Survivin and P-glycoprotein are associated and highly expressed in late phase chronic myeloid leukemia

Tumor Biology and Prognostic Factors in Renal Cell Carcinoma

Contact Info

Product

Resources

About