Significance of oxygen free radicals in the pathophysiology of hemorrhagic shock - A protocol

Premaratne, Shyamal; Amaratunga, Dhanushya T.; Mensah, Francis; McNamara, J. Judson

doi:10.1016/j.isjp.2018.04.002

Cited by 6 publications

(5 citation statements)

References 26 publications

(28 reference statements)

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“…This study showed that continuous infusion of 4% albumin reduced the risk of nosocomial infections in patients in the ICU. By mixing albumin with oxidized vasostatin-1 and using a high-performance liquid chromatography (HPLC) method, it was demonstrated that albumin reduced the oxidized form of vasostatin, thereby restoring and increasing its antibacterial properties [ 2 , 3 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Common complications, that include acute respiratory distress syndrome (ARDS), acute renal failure (ARF), myocardial depression, and liver dysfunction, can occur in such a patient. This condition associated with the oxidative stress elicited in cells following ischemia or hypoxia and resuscitation known as reperfusion injury [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…The accelerated ROS production in postischemic tissues attributes to one or more enzymes that are capable of reducing molecular oxygen to form superoxide and/or hydrogen peroxide, with the subsequent release of ROS into the intracellular and/or extracellular compartments. The enzyme systems most commonly invoked to explain the accelerated ROS production in postischemic tissues are xanthine oxidase, NADPH oxidase, the mitochondrial electron transport chain, and uncoupled nitric oxide synthase [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

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The effect of Channa striata, Moringa oleifera, and Curcuma xanthorrhiza extract on accelerating recovery in a ventilated patient with hemorrhagic shock grade 3 due to prolonged retained placenta: a case report

Rahardjo,

Suryawan,

Rumouw

et al. 2024

J Med Case Reports

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Background Most of critically ventilated patients with severe hemorrhagic shock experience metabolic acidosis, hypoalbuminemia, electrolyte imbalance, and increased production of free radical. Channa striata has a high content of albumin, an essential binding protein that contributes to homeostasis, and when combined with Moringa oleifera and Curcuma xanthorrhiza, they act as powerful antioxidants. Administration of C. striata, M. oleifera, and C. xanthorrhiza extract orally may benefit patient with hemodynamic issues, including significant blood loss. Case report A 40-year-old Indonesian woman came to emergency department with decreased consciousness resulting from hemorrhagic shock grade 3 due to prolonged placenta retention for 10 days after delivery of her third child. She had an emergency hysterectomy and was sent to the intensive care unit with a hemoglobin level of 4.2 gr/dL, despite already receiving two bags of packed red blood cells during operation, and she continued with four more bags within her first day in the intensive care unit. The patient was ventilated, was supported by vasopressors, and had a low albumin level of 2.1 gr/dL. Her hemodynamic profile was difficult to stabilize, with persistent gastric residue and periodic urine output less than 1 cc/kg/hour, thereby slowing the ventilator and vasopressor weaning process. Oral supplementation of C. striata, M. oleifera, and C. xanthorrhiza was given in the second day divided in three doses every 6 hours. After the second dose, gastric residue started to subside and disappeared after the third dose. The patient’s condition improved in the next 24 hours; she was extubated and discharged from the hospital in the fourth day. Conclusion This is the first case report describing the effect of C. striata, M. oleifera, and C. xanthorrhiza extract in a patient with severe hemorrhagic shock due to a prolonged placenta. Accelerated recovery showed the possibility benefit of C. striata, M. oleifera, and C. xanthorrhiza extract in stabilizing oncotic pressure, neutralizing free radicals, and preventing further damage in hypoxic cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effect of Channa striata, Moringa oleifera, and Curcuma xanthorrhiza extract on accelerating recovery in a ventilated patient with hemorrhagic shock grade 3 due to prolonged retained placenta: a case report

Rahardjo,

Suryawan,

Rumouw

et al. 2024

J Med Case Reports

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show abstract

“…The excess free radicals, regardless of whether they are generated by the mitochondrial respiratory chain or NAD(p)H, can cause oxidative stress, which has a direct impact on cells. This can result in cell damage and eventually various diseases [ 6 , 7 , 8 , 9 ], such as cardiovascular diseases, cancer, neurological disorders, diabetes, ischemia/reperfusion, and aging [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ], which is also one of the risks of STI intake. In vivo, Vitamin C (VC) can react with oxygen free radicals through redox reactions, thereby neutralizing them and safeguarding the body against their damaging effects.…”

Section: Introductionmentioning

confidence: 99%

Effects of Soybean Trypsin Inhibitor on Pancreatic Oxidative Damage of Mice at Different Growth Periods

Yang

Li³

et al. 2023

Foods

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The bioactive components in soybeans have significant physiological functions. However, the intake of soybean trypsin inhibitor (STI) may cause metabolic disorders. To investigate the effect of STI intake on pancreatic injury and its mechanism of action, a five-week animal experiment was conducted, meanwhile, a weekly monitor on the degree of oxidation and antioxidant indexes in the serum and pancreas of the animals was carried out. The results showed that the intake of STI had irreversible damage to the pancreas, according to the analysis of the histological section. Malondialdehyde (MDA) in the pancreatic mitochondria of Group STI increased significantly and reached a maximum (15.7 nmol/mg prot) in the third week. Meanwhile, the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), trypsin (TPS), and somatostatin (SST) were decreased and reached minimum values (10 U/mg prot, 87 U/mg prot, 2.1 U/mg prot, 10 pg/mg prot) compared with the Group Control. The RT-PCR results of the expression of SOD, GSH-Px, TPS, and SST genes were consistent with the above. This study demonstrates that STI causes oxidative structural damage and pancreatic dysfunction by inducing oxidative stress in the pancreas, which could increase with time.

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“…Free radicals are atoms, elements, compounds, or molecules that have one or more unpaired electrons in their outer orbitals [4]. These unpaired electrons are very reactive and tend to look for pairs by attacking and binding electrons to stable molecules around them [5][6][7]. The mechanism or process of free radical formation has several stages.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Exposure to Aerosol Mosquitoes Repellent Related to Free Radicals on the Organs of Male Mice

Juswono¹

2020

GEOMATE

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From year to year, human activities using chemical substances lead to pollute ambient air and affect human health. This pollutant can pass through the respiratory system and disrupts the organ function, including lung, liver, blood, and kidney. It can be identified by the deformation found in the structure and function change of the related cells in these organs and the existence of free radical. On the other hand, each substance has a different composition and health effect. The possibility of the free radical type that is formed is also different and related to the substance. According to this background, it a need to determine the presence of free radicals in the mice's organs exposed to one push aerosol mosquito repellents as the substance. This study aimed to investigate the free radicals on the mice's organs due to the exposure to aerosol mosquito repellent and its relation with the organ damage of cell deformation. This study used male mice as the experimental animals that were divided into control and treatment groups. The study included two types of repellents, Type-A (25% of aerosol concentration) and Type-B (21.3% of aerosol concentration). Free radicals were detected using an electron spin resonance device. The results showed that the cell deformation due to the exposure of one push aerosol was different for each organ. The deformation levels were about 36% to 74% that depended on the aerosol concentration. The exposed aerosol generated anion superoxide (O2-) and singlet oxygen radicals (1O2) as the free radicals found in the observed organs.

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Significance of oxygen free radicals in the pathophysiology of hemorrhagic shock - A protocol

Abstract: HighlightsFree radicals can cause significant tissue damage.Scavengers of free radicals are a useful way to reduce reperfusion injury.Electron Paramagnetic Resonance (EPR) spectroscopy is the best way to detect free radicals.

Cited by 6 publications

References 26 publications

The effect of Channa striata, Moringa oleifera, and Curcuma xanthorrhiza extract on accelerating recovery in a ventilated patient with hemorrhagic shock grade 3 due to prolonged retained placenta: a case report

The effect of Channa striata, Moringa oleifera, and Curcuma xanthorrhiza extract on accelerating recovery in a ventilated patient with hemorrhagic shock grade 3 due to prolonged retained placenta: a case report

Effects of Soybean Trypsin Inhibitor on Pancreatic Oxidative Damage of Mice at Different Growth Periods

The Impact of Exposure to Aerosol Mosquitoes Repellent Related to Free Radicals on the Organs of Male Mice

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