Significance of ovomucoid- and ovalbumin-specific IgE/IgG4 ratios in egg allergy

Caubet, Jean Christoph; Bencharitiwong, Ramon; Moshier, Erin; Godbold, James; Sampson, Hugh A.; Nowak‐Węgrzyn, Anna

doi:10.1016/j.jaci.2011.11.053

Cited by 112 publications

(100 citation statements)

References 54 publications

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“…In clinical studies of subcutaneous aeroallergen immunotherapy for allergic rhinitis, increases in specific IgG "blocking" antibodies are strongly correlated with effective desensitization (Akdis, Barlan, Bahceciler, & Akdis, 2006;James et al, 2011;Lichtenstein, Holtzman, & Burnett, 1968). Similar relationships between antigen-specific IgG induction and efficacy of desensitization have been observed in OIT trials for food allergy (Bedoret et al, 2012;Caubet et al, 2012;Jones et al, 2009;Kim et al, 2011;Skripak et al, 2008;Vickery et al, 2013Vickery et al, , 2014. As previously observed for aeroallergen immunotherapy, induction of the IgG4 isotype has emerged as the best clinical correlate for desensitization.…”

Section: Igg:fcγriib-mediated Inhibition Of Mast Cell Activationsupporting

confidence: 72%

IgE and Mast Cells

Oettgen

Burton

2015

Advances in Immunology

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Section: Igg:fcγriib-mediated Inhibition Of Mast Cell Activationsupporting

confidence: 72%

IgE and Mast Cells

Oettgen

Burton

2015

Advances in Immunology

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“…2,[35][36][37][38][39][40][41][42] Several studies focused on egg allergy, 38,43,44 particularly whether diagnostic testing could determine when extensively heated egg (baked into wheat-based foods) would be tolerated in subjects with egg allergy. Lieberman et al 44 reported the results of 100 OFCs to baked egg in children, with a 66% rate of tolerance.…”

Section: Diagnosismentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012

Sicherer

Leung

2013

Journal of Allergy and Clinical Immunology

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This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2012. Studies support an increase in peanut allergy prevalence in children and exposure to the antibacterial agent triclosan and having filaggrin (FLG) loss-of-function mutations as risk factors for food sensitization. The role of specific foods in causing eosinophilic esophagitis is elucidated by several studies, and microRNA analysis is identified as a possible noninvasive disease biomarker. Studies on food allergy diagnosis emphasize the utility of component testing and the possibility of improved diagnosis through stepped approaches, epitope-binding analysis, and bioinformatics. Treatment studies of food allergy show promise for oral immunotherapy, but tolerance induction remains elusive, and additional therapies are under study. Studies on anaphylaxis suggest an important role for platelet-activating factor and its relationship to the need for prompt treatment with epinephrine. Insights on the pathophysiology and diagnosis of non-IgE-mediated drug allergy are offered, with novel data regarding the interaction of drugs with HLA molecules. Numerous studies support influenza vaccination of persons with egg allergy using modest precautions. Evidence continues to mount that there is cross-talk between skin barrier defects and immune responses in patients with atopic dermatitis. Augmentation of the skin barrier with reduction in skin inflammatory responses will likely lead to the most effective intervention in patients with this common skin disease.

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“…The role of IgG4 in physiologic immune responses and in allergic diseases is under investigation. Some studies have found a negative correlation between IgG4 titers and symptom score (8)(9)(10)(11)(12)(13) and a positive correlation between IgG4 titers and IL-10-secreting APCs (14) following specific immunotherapy. Nouri-Aria et al (15) found that during specific immunotherapy, allergen-specific IgG4 serum levels increase 10-to 100-fold, and they conclude that grass pollen immunotherapy may induce allergen-specific, IL-10-dependent "protective" IgG4 responses.…”

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confidence: 99%

IgG4 and IgE Transcripts in Childhood Allergic Asthma Reflect Divergent Antigen-Driven Selection

Rogosch

Kerzel

Dey

et al. 2014

The Journal of Immunology

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The physiologic function of the “odd” Ab IgG4 remains enigmatic. IgG4 mediates immunotolerance, as, for example, during specific immunotherapy of allergies, but it mediates tissue damage in autoimmune pemphigus vulgaris and “IgG4-related disease.” Approximately half of the circulating IgG4 molecules are bispecific owing to their unique ability to exchange half-molecules. Better understanding of the interrelation between IgG4 and IgE repertoires may yield insight into the pathogenesis of allergies and into potential novel therapies that modulate IgG4 responses. We aimed to compare the selective forces that forge the IgG4 and IgE repertoires in allergic asthma. Using an IgG4-specific RT-PCR, we amplified, cloned, and sequenced IgG4 H chain transcripts of PBMCs from 10 children with allergic asthma. We obtained 558 functional IgG4 sequences, of which 286 were unique. Compared with previously published unique IgE transcripts from the same blood samples, the somatic mutation rate was significantly enhanced in IgG4 transcripts (62 versus 83%; p < 0.001), whereas fewer IgG4 sequences displayed statistical evidence of Ag-driven selection (p < 0.001). On average, the hypervariable CDRH3 region was four nucleotides shorter in IgG4 than in IgE transcripts (p < 0.001). IgG4 transcripts in the circulation of children with allergic asthma reflect some characteristics of classical Ag-driven B2 immune responses but display less indication of Ag selection than do IgE transcripts. Although allergen-specific IgG4 can block IgE-mediated allergen presentation and degranulation of mast cells, key factors that influence the Ag-binding properties of the Ab differ between the overall repertoires of circulating IgG4- and IgE-expressing cells.

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Significance of ovomucoid- and ovalbumin-specific IgE/IgG4 ratios in egg allergy

Cited by 112 publications

References 54 publications

IgE and Mast Cells

IgE and Mast Cells

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012

IgG4 and IgE Transcripts in Childhood Allergic Asthma Reflect Divergent Antigen-Driven Selection

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