2020
DOI: 10.21203/rs.2.24386/v1
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Significance of nuclear upregulation of LOXL2 in fibroblasts and myofibroblasts in the fibrotic process of acute respiratory distress syndrome

Abstract: Background: Fibrotic scarring is an important prognostic factor for acute respiratory distress syndrome (ARDS). Lysyl oxidase-like 2 (LOXL2), an amine oxidase, is thought to make an integral contribution to fibrotic scarring by facilitating collagen cross-linking. LOXL2 has also been proposed to epigenetically regulate gene expression to direct cell fate. Recent clinical outcomes demonstrated the ineffectiveness of an inhibitory monoclonal antibody against LOXL2 in patients with organ fibrosis, including fibro… Show more

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