Significance of Nickel in Livestock Health and Production

Samal, Lipismita; Mishra, Chinmoy

doi:10.5455/ijavms.20110331111304

Cited by 22 publications

(22 citation statements)

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“…Ni is not only an essential element for more than 100 compounds but also an essential element for many animals, microorganisms, and plants [1][2][3]. In animals, Ni deficiency inhibits growth, reduces reproductive rate, alters glucose and lipid metabolism, and is associated with anemia, low hemoglobin values, and alterations of metal ion contents [4]. Ni and Ni compounds are used in a wide variety of industrial and consumer application [5].…”

Section: Introductionmentioning

confidence: 99%

Nickel Chloride (NiCl2) Induces Histopathological Lesions via Oxidative Damage in the Broiler’s Bursa of Fabricius

Yin¹,

Guo²,

Cui

et al. 2015

Biol Trace Elem Res

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The purpose of this study was to investigate the histopathological lesions, oxidative damage, changes of immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA) contents in the bursa of Fabricius and serum immunoglobulins (IgG, IgM, IgA) induced by dietary nickel chloride (NiCl2). Two hundred and eighty-one-day-old broilers were randomly divided into four groups and fed on a control diet and three experimental diets supplemented with 300, 600, and 900 mg/kg of NiCl2 for 42 days. Lesions were observed in the NiCl2-treated groups. Histopathologically, lymphocytes were decreased in lymphoid follicles with thinner cortices and wider medullae. Concurrently, the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and the ability to inhibit hydroxyl radical and glutathione (GSH) contents were significantly (p < 0.05 or p < 0.01) decreased, while malondialdehyde (MDA) contents were increased in the NiCl2-treated groups. The serum IgG, IgM, and bursa IgG and IgM contents were significantly (p < 0.05 or p < 0.01) lower in the NiCl2-treated groups than those in the control group. The above-mentioned results show that dietary NiCl2 in excess of 300 mg/kg can cause histopathological lesions via oxidative damage, which finally impairs the function of the bursa of Fabricius and reduces IgG and IgM contents of the serum and the bursa of Fabricius. The study is aimed to provide helpful materials for studies on Ni- or Ni compounds-induced B cell toxicity in both human and other animals in the future.

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Section: Introductionmentioning

confidence: 99%

Nickel Chloride (NiCl2) Induces Histopathological Lesions via Oxidative Damage in the Broiler’s Bursa of Fabricius

Yin¹,

Guo²,

Cui

et al. 2015

Biol Trace Elem Res

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“…Albumen weight and content were significantly decreased in the highest dose group as compared to controls. It is notable that the adverse effect of Ni on egg production has been seen at unusually low levels rather in the range of Ni doses considered to be beneficial to several livestock species (Samal and Mishra, 2011). Moreover, the authors reported that body weight was significantly reduced at values of 0.20 mg/kg feed thereby contradicting the results of several other poultry studies reporting Ni induced body weight reduction only at much higher values (see Table 11).…”

Section: Poultrymentioning

confidence: 89%

“…Dietary Ni requirement for monogastric species appear to be between 0.050 and 0.200 mg Ni/kg of feed (Samal and Mishra, 2011). Signs of Ni deprivation have been described for several livestock species including chickens, cows, goats, minipigs and sheep.…”

Section: Adverse Effects Of Nickel In Livestock Fish Cats and Dogsmentioning

confidence: 99%

Scientific Opinion on the risks to animal and public health and the environment related to the presence of nickel in feed

Publication¹

2015

EFS2

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Following a request from the European Commission, the risks to animal and human health and the environment related to the presence of nickel (Ni) in feed were assessed by the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel). The presence of Ni in feed can arise from both natural and anthropogenic sources. Additionally, certain feed materials contain metallic Ni, since it is used as a catalyst in their production. Based on the differences observed between the Ni exposure levels estimated for different animal species and identified no observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs), the CONTAM Panel concluded that any adverse impact of Ni via feed to cattle, pigs, rabbits, ducks, fish, dogs, chickens, horses, sheep, goats and cats is unlikely. Concerning the assessment of human health risks from the presence of Ni in food of animal origin, the CONTAM Panel concluded that in the average population the current levels of chronic exposure to Ni, considering only foods of animal origin, might be of potential concern in the young population, in particular in 'Toddlers'. In the highly exposed population (95th percentile), the concern also extends to the age class 'Other children'. Regarding acute dietary exposure, the CONTAM Panel concluded that Ni-sensitized individuals are also at risk of developing eczematous flare-up skin reactions through the consumption of food of animal origin. The contribution of food of animal origin to human dietary exposure to Ni should therefore not be underestimated, particularly in age classes with high dietary exposure to Ni. Release to the environment from manure, resulting from its presence in animal feed, is not a major contributor of Ni deposited onto agricultural soils or to the environment. SUMMARYFollowing a request from the European Commission, the risks to animal and human health and the environment related to the presence of nickel (Ni) in feed were assessed by the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel).Ni is a metal that occurs in a number of different soluble and particulate forms, which are ubiquitously found in the environment both from natural occurrence and from anthropogenic activity. Animal feed contains Ni, particularly in the divalent form, its most stable oxidation state. Additionally certain vegetable oils can contain traces of metallic Ni, since it is used as a catalyst in their hydrogenation.Following a call for data, two European countries, submitted 1 813 results on Ni concentrations in feed of which 1 794 were from one country. All results were reported as total Ni, with no differentiation between Ni species. Feed related exposure to Ni was estimated by applying two different scenarios, namely (i) exposures based on Ni concentrations in compound feed and forages and (ii) exposures derived from Ni in feed materials including hydrogenated vegetable oils. For compound feed, 317 results were provided, though the livestock species for which these feeds had been manufactured were not gi...

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“…Anke et al [5] reported an absolute requirement for nickel in the ruminants (sheep, goat, and so on). Ni deficiency inhibits growth, reduces reproductive rate, and alters glucose and lipid metabolism, which are associated with anemia, hemoglobin reduction, alternations of metal ion contents, and reduced activity of several enzymes in animals [6]. However, Ni or Ni compounds can enter the food chain and may be toxic to living organisms.…”

mentioning

confidence: 99%

Effects of Nickel Chloride on Histopathological Lesions and Oxidative Damage in the Thymus

Tang¹,

Li²,

Yin³

et al. 2014

Health

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The purpose of this study was to observe the histopathological lesions and oxidative damage induced by dietary nickel chloride (NiCl 2 ) in the thymus. A total of 280 one-day-old avian broilers were divided into four groups and fed on a corn-soybean basal diet as the control diet or the same basal diet supplemented with 300, 600, and 900 mg/kg of NiCl 2 for 42 days. In the NiCl 2 -treated groups, the broiler weight and thymic relative weight were significantly (P < 0.05 or P < 0.01) decreased. Histopathologically, thymic corpuscles were increased and enlarged; the reticular cells were degenerate and necrotic, and lymphocytes were slightly decreased and loosely arranged in the medulla of thymus in the 600 mg/kg and 900 mg/kg groups. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and the ability to inhibit hydroxy radical and glutathione (GSH) content were significantly (P < 0.05 or P < 0.01) lower in the NiCl2-treated groups than those in the control group, while MDA content was higher. The abovementioned results demonstrated that dietary NiCl 2 in excess of 300 mg/kg could reduce the broiler weight and thymic relative weight, and cause histopathological lesions and oxidative damage in the thymus, which finally impaired the thymic function.

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Significance of Nickel in Livestock Health and Production

Cited by 22 publications

References 14 publications

Nickel Chloride (NiCl2) Induces Histopathological Lesions via Oxidative Damage in the Broiler’s Bursa of Fabricius

Nickel Chloride (NiCl2) Induces Histopathological Lesions via Oxidative Damage in the Broiler’s Bursa of Fabricius

Scientific Opinion on the risks to animal and public health and the environment related to the presence of nickel in feed

Effects of Nickel Chloride on Histopathological Lesions and Oxidative Damage in the Thymus

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