Significance of Minute Focus of Adenocarcinoma on Prostate Needle Biopsy

Samaratunga, Hemamali; Yaxley, John; Kerr, Kris; McClymont, Kelly; Duffy, David L.

doi:10.1016/j.urology.2007.03.068

Cited by 11 publications

(13 citation statements)

References 21 publications

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“…PSM status represents a surrogate marker for surgical quality in organ‐confined disease and is a risk factor for subsequent BCF. There were nine studies that reported on surgical margin status after ORP with overall PSM rates varying from 12%[20] to 46.7%[21]. This compared with overall PSM rates of between 15.5%[22] and 21.2%[6] for RALP and between 8%[16] and 23%[15] for LRP.…”

Section: Resultsmentioning

confidence: 99%

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Perioperative, functional and oncological outcomes after open and minimally invasive prostate cancer surgery: experience from Australasia

Cathcart¹,

Murphy²,

Moon³

et al. 2011

BJU International

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RESULTS• Overall, the data are limited by the low methodological quality of available studies.• Only two comparative studies evaluating open radical prostatectomy (ORP) and robotic-assisted laparoscopic RP (RALP) were identified, both non-randomized.• The mean blood loss, catheterization time and hospital stay was shorter after RALP than with ORP. In contrast, mean operative procedure time was significantly longer for RALP.• Overall adverse event rates were similar for the different surgical approaches although the rate of bladder neck stricture was significantly higher after open RP.

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Section: Resultsmentioning

confidence: 99%

“…The studies were grouped according to surgical method and then in chronological order by date of publication and are summarized in tabular form in Table 1[6–33].…”

Section: Methodsmentioning

confidence: 99%

Perioperative, functional and oncological outcomes after open and minimally invasive prostate cancer surgery: experience from Australasia

Cathcart¹,

Murphy²,

Moon³

et al. 2011

BJU International

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“…The recent recommendation of increasing the number of biopsy cores and/or transperineal approach has generated a greater prostate cancer detection rate [24] . Whether this will lead to detection of insignificant cancers is being debated [25] . These aspects will have to be considered in future studies.…”

Section: Discussionmentioning

confidence: 99%

Detection Rate and Clinical Pattern of Prostate Cancer in Kuwait: A Single-Center Experience

Arun

Abul²,

Mathew

2010

Med Princ Pract

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Objective: To determine the detection rate and clinical pattern of prostate cancer in Kuwait. Subjects and Methods: One hundred and fifty-three males suspected of having prostate cancer based on elevation of prostate-specific antigen (PSA) of more than 4 ng/ml underwent transrectal-ultrasound (TRUS)-guided needle biopsy of the prostate between January 2003 and January 2008; these formed the study group. Analysis of prostate cancer was based on age, prostate volume, PSA level and on finding any abnormality based on a combination of the diagnostic tools. Results: A diagnosis of prostate cancer was histologically confirmed in 42 (27.4%) patients. In those aged <55, 56–65, 66–75 and >76 years, the detection rates were 16.7, 17.6, 33.3 and 40.7%, respectively. In those with prostate volumes of >71, 51–70, 31–50 and <30 g, the detection rates were 18.2, 23.8, 30.8 and 42.9%, respectively. When the PSA levels were divided into groups of 4–10, 10–20, 20–100 and >100 ng/ml, the cancer detection rate was 11.8, 20.5, 47.1 and 83.3%, respectively. When 1, 2 and 3 of the 3 diagnostic tools (digital rectal examination, PSA, TRUS) were abnormal, the detection rate was 15.6, 27.9 and 80%, respectively. Conclusions: Our data showed that the prostate cancer rate differs according to the region and that the rate was low in our center. Higher PSA and higher number of diagnostic tools with abnormal findings were associated with a higher incidence of prostate cancer.

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“…There are three well-established prognostic factors: Gleason score ≤ 6, organ-confi ned disease, and tumor volume < 0.5 cm 3 . The reported risk of IPCa on radical prostatectomy specimens after such a diagnosis has varied in the literature (10). Allan et al (11) reported that most patients with limited tumor (≤ 0.5 mm in extent) have had IPCa, while only 33 % of the patients had tumors warranting defi nite therapy at fi nal pathology.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of upgrading, Gleason score 6 (3 + 3) to ≥ 7 at radical prostatectomy specimens is a mean of 36 % and a median of 35.5 % (range 14-51 %) in literature (12). Samaratunga et al (10) reported the incidence of upgrading the patients with 0.5 mm focus or less of GS 6 on needle biopsy to be 31.8. PSA levels, pathology weight, age, extent of cancer on biopsy and needle biopsy sampling can affect the incidence of upgrading (17).…”

Section: Discussionmentioning

confidence: 99%

Active surveillance or radical prostatectomy? Which treatment is best?

Çalışkan¹,

Mo²,

Kaba³

et al. 2016

BLL

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OBJECTIVE: We evaluated the patients who are candidates for active surveillance and treated with radical prostatectomy. These patients were compared with other patients who had not met the criteria of active surveillance. METHODS: In total, 135 patients were included in the study. The patients were divided into two groups. The patients in Group 1 had less than three positive cores, Gleason 6 (3 + 3) and PSA level equal to or less than 10 ng/ml. Patients in Group 2 had three or more positive cores, Gleason 6 (3 + 3) and PSA level equal to or higher than 10 ng/ml. Pathological results of each groups were compared. RESULTS: The patients' ages were between 52 and 76, and 50 and 77 in groups 1 and 2, retrospectively. There were 69 and 66 patients in groups 1 and 2, retrospectively. The mean age of patients, PSA levels, PSA density, and prostate volumes were 63.89 ± 5.89 years, 5.82 ± 1.84 ng/ml, 0.14 ± 0.07 and 51.21 ± 31.75 cc (Group 1) and 65.77 ± 6.36 years, 13.65 ± 17.11 ng/ml, 0.63 ± 1.03 and 45.44 ± 26.77 cc (Group 2). T2a, T2c, T3a and T3b were reported in 28 patients, 36 patients, 3 patients and 2 patients after pathological evaluation in Group 1, respectively. T2a, T2c, T3a and T3b were reported in 13 patients, 47 patients, 5 patients and 1 patient in the other group, respectively. CONCLUSION: The fi nal pathology showed that there is no difference in the positive surgical margin, proportion of insignifi cant prostate cancer and Gleason upgrading between groups. The clinicians must be aware of the fact that active surveillance can be misdiagnosed in some patients (Tab. 2, Ref. 20). Text in PDF www.elis.sk. KEY WORDS: prostate cancer, cancer-specifi c death, prostate specifi c antigen, PSA testing retropubic prostatectomy.

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Significance of Minute Focus of Adenocarcinoma on Prostate Needle Biopsy

Cited by 11 publications

References 21 publications

Perioperative, functional and oncological outcomes after open and minimally invasive prostate cancer surgery: experience from Australasia

Perioperative, functional and oncological outcomes after open and minimally invasive prostate cancer surgery: experience from Australasia

Detection Rate and Clinical Pattern of Prostate Cancer in Kuwait: A Single-Center Experience

Active surveillance or radical prostatectomy? Which treatment is best?

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