Significance of microvascular density (MVD) in cervical cancer recurrence

León, David Cantú de; López-Graniel, C.; Mendivil, Mauricio Frías; Vilchis, Gregorio Chanona; Gómez, Carolina Jaramillo; Salazar, Jaime de

doi:10.1136/ijgc-00009577-200311000-00018

Cited by 9 publications

(5 citation statements)

References 23 publications

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“…[2] Tumor-associated endothelial cells secrete pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF). [3] Plexin D1 was initially suggested to be a tumor marker, as it was found to be over expressed in brain tumours. [4] Plexin D1 was originally described as a receptor for the semaphorin Sema3E, [5] and it has been reported that semaphorins can effect migration and proliferation of some tumour cells.…”

Section: Introductionmentioning

confidence: 99%

Plexin D1: New Potential Biomarker for Cervical Cancer

Shalaby

Hampson

Oliver

et al. 2012

Journal of Immunoassay and Immunochemistry

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To explore possible role of Plexin D1 in cancer angiogenesis with special focus on cervical cancer. Twelve various normal tissues, 12 various tumor samples, and 59 different stages of cervical cancer samples on tissue microarrays were examined for the expression of Plexin D1. The findings of our study clearly indicate that Plexin D1 is strongly associated with cellular differentiation in the tissues investigated, and that expression is strongly dependent on the tumor histotype. In some tumor subtypes, the protein was detected at several-fold higher levels than was found in the corresponding normal tissues, while in others, expression was similar to normal tissues. Most significantly, strong expression was detected in the endothelial cells of the cervical cancer samples, yet no expression was seen in endothelial cells of normal cervical tissues, which suggests a potential role of Plexin D1 in cervical cancer-associated angiogenesis.Regarding the implications of Plexin D1 and its associations with cancer angiogenesis, it might be a potential cervical cancer biomarker if further studies confirm the present preliminary findings.

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Section: Introductionmentioning

confidence: 99%

Plexin D1: New Potential Biomarker for Cervical Cancer

Shalaby

Hampson

Oliver

et al. 2012

Journal of Immunoassay and Immunochemistry

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“…Several studies document the association between the MVD and ⁄ or the extent of endothelial proliferation, the pre-cancer and tumor stage, and the invasive disease of the cervical cancer. (3)(4)(5)(6) The expression of various angiogenesis stimulators, such as VEGFs, angiopoietins, and thymidine phosphorylase, has been reported in cervical cancer and dysplasia. (7,8) Several published reports similarly report stromal LVD in cervical neoplasia.…”

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confidence: 99%

Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas

et al. 2010

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The aim of the present study is to clarify the critical roles of vasohibin in cervical carcinomas. We investigated the expression ratios of vasohibin and vascular endothelial growth factor (VEGF) receptor-2 on endothelium and microvessel density, lymphatic vessel density (LVD) by immunohistochemistry. Sixty-one squamous cell carcinoma (SCC), 18 mucinous adenocarcinoma (Adenocarcinoma), 38 carcinoma in situ (CIS), and 35 normal cervical epithelium were collected. We investigated the expression of vasohibin and compared it with the expression of VEGF receptor-2 (VEGFR-2, KDR/flk-1), and CD34 in the stromal endothelium. Expression of VEGF was counted using the histological score (H score). D2-40 was used as a marker for lymphatic endothelial cells to investigate LVD. The microvessel density of the normal cervical epithelium was significantly lower than that of CIS, SCC, and Adenocarcinoma (P < 0.05). The expression ratio of vasohibin in the normal cervical epithelium was significantly lower than that of SCC and Adenocarcinoma (P < 0.05). The expression ratio of VEGFR-2 of the normal cervical epithelium was significantly lower than that of SCC and Adenocarcinoma (P < 0.05). The LVD of the normal cervical epithelium was significantly lower than that of CIS, SCC, and Adenocarcinoma (P < 0.05). For normal cervical epithelium, CIS, and SCC, there was a moderate correlation between the expression percentage of vasohibin and the expression percentage of VEGFR-2 (P < 0.05, r 2 = 0.3018). This is the first study to elucidate the correlation between the expression of vasohibin in the stromal endothelial cells and the expression of VEGFR-2 in human cervical carcinomas. (Cancer Sci 2011; 102: 446-451) C ervical carcinoma is a common gynecologic malignancy in women worldwide. In 2008 in the USA, an estimated 11 070 new cases of invasive cervical cancer were diagnosed and 3870 cancer-related deaths were expected to occur; this represents approximately 1% of cancer deaths in women.1 The morbidity of cervical cancer, especially in women younger than 40 years old, is rapidly increasing and is the worst in Japan.2 It is well recognized that angiogenesis (the process of forming new vessels) is required for tumor growth and enables the hematogenous spread of tumor cells throughout the cervical cancer. Several studies document the association between the MVD and ⁄ or the extent of endothelial proliferation, the pre-cancer and tumor stage, and the invasive disease of the cervical cancer. (3)(4)(5)(6) The expression of various angiogenesis stimulators, such as VEGFs, angiopoietins, and thymidine phosphorylase, has been reported in cervical cancer and dysplasia. (7,8) Several published reports similarly report stromal LVD in cervical neoplasia. (9)(10)(11) Angiogenesis is determined by the local balance between angiogenic stimulators and inhibitors. However, the significance of endogenous angiogenesis inhibitors in cervical cancer is poorly documented.We isolated a novel angiogenesis inhibitor, vasohibin, which is specifically expresse...

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“…Neoangiogenesis underlies solid tumor growth and malignant progression. For tumor tissue to proliferate and metastasize, neovascularization within it must have a certain phenotype before it can be achieved [ 19 ]. Quantitative analysis of microvessels in tumor tissues by immunohistochemical staining of vascular endothelial cell antigens accurately reflects the angiogenesis of tumor tissues [ 20 ], which is an important indicator for assessing whether tumor tissues were invasive, metastatic, recurrent for evaluating therapeutic efficacy, the results have been confirmed by a large number of studies.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of one-stop CT energy spectrum and perfusion for angiogenesis in colon and rectum cancer

Zhao,

Zhou,

et al. 2024

BMC Med Imaging

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Objective Evaluation of the predictive value of one-stop energy spectrum and perfusion CT parameters for microvessel density (MVD) in colorectal cancer cancer foci. Methods Clinical and CT data of 82 patients with colorectal cancer confirmed by preoperative colonoscopy or surgical pathology in our hospital from September 2019 to November 2022 were collected and analyzed retrospectively. Energy spectrum CT images were measured using the Protocols general module of the GSI Viewer software of the GE AW 4.7 post-processing workstation to measure the CT values of the arterial and venous phase lesions and the neighboring normal intestinal wall in a single energy range of 40 kev∼140 kev, and the slopes of the energy spectrum curves (λ) were calculated between 40 kev-90 kev; Iodine concentration (IC), Water concentration (WC), Effective-Z (Eff-Z) and Normalized iodine concentration (NIC) were measured by placing a region of interest (ROI) on the iodine concentration map and water concentration map at the lesion and adjacent to the normal intestinal wall.Perfusion CT images were scanned continuously and dynamically using GSI Perfusion software and analyzed by applying CT Perfusion 4.0 software.Blood volume (BV), blood flow (BF), surface permeability (PS), time to peak (TTP), and mean transit time (MTT) were measured respectively in the lesion and adjacent normal colorectal wall. Based on the pathological findings, the tumors were divided into a low MVD group (MVD < 35/field of view, n = 52 cases) and a high MVD group (MVD ≥ 35/field of view, n = 30 cases) using a median of 35/field of view as the MVD grouping criterion. The collected data were statistically analyzed, the subjects’ operating characteristic curve (ROC) was plotted, and the area under curve (AUC), sensitivity, specificity, and Yoden index were calculated for the predicted efficacy of each parameter of the energy spectrum and perfusion CT and the combined parameters. Results The CT values, IC, NIC, λ, Eff-Z of 40kev∼140kev single energy in the arterial and venous phase of colorectal cancer in the high MVD group were higher than those in the low MVD group, and the differences were all statistically significant (p < 0.05). The AUC of each single-energy CT value in the arterial phase from 40 kev to 120 kev for determining the high or low MVD of colorectal cancer was greater than 0.8, indicating that arterial stage has a good predictive value for high or low MVD in colorectal cancer; AUC for arterial IC, NIC and IC + NIC were all greater than 0.9, indicating that in arterial colorectal cancer, both single and combined parameters of spectral CT are highly effective in predicting the level of MVD. The AUC of 40 kev to 90 kev single-energy CT values in the intravenous phase was greater than 0.9, and its diagnostic efficacy was more representative; The AUC of IC and NIC in venous stage were greater than 0.8, which indicating that the IC and NIC energy spectrum parameters in venous stage colorectal cancer have a very good predictive value for the difference between high and low MVDs, with the greatest diagnostic efficacy in IC.The values of BV and BF in the high MVD group were higher than those in the low MVD group, and the differences were statistically significant (P < 0.05), and the AUC of BF, BV, and BV + BF were 0.991, 0.733, and 0.997, respectively, with the highest diagnostic efficacy for determining the level of MVD in colorectal cancer by BV + BF. Conclusion One-stop CT energy spectrum and perfusion imaging technology can accurately reflect the MVD in living tumor tissues, which in turn reflects the tumor angiogenesis, and to a certain extent helps to determine the malignancy, invasion and metastasis of living colorectal cancer tumor tissues based on CT energy spectrum and perfusion parameters.

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Significance of microvascular density (MVD) in cervical cancer recurrence

Cited by 9 publications

References 23 publications

Plexin D1: New Potential Biomarker for Cervical Cancer

Plexin D1: New Potential Biomarker for Cervical Cancer

Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas

Diagnostic value of one-stop CT energy spectrum and perfusion for angiogenesis in colon and rectum cancer

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