Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

Abstract

The effect of anti-Lyt2 on the generation of helper T-cell function and on cytotoxic effects specific for subregions of the major histocompatibility complex (MHC) was determined. The addition of anti-Lyt2 without complement to in vitro

Role of T Lymphocyte Subsets in Protection and Recovery from Hantaan Virus Infection in Mice

“…Mature T cells have been found to express either L3T4 antigen or Lyt2 antigen, but not both (Dialynas et al, 1983a, b). Moreover L3T4 ÷ Lyt2-T cells are restricted by major histocompatibility complex (MHC) class II antigens and seem to constitute the majority of helper/inducer cells, whereas L3T4-Lyt2 + T cells recognize MHC class I antigens and apparently constitute the majority of cytotoxic/suppressor cells (Swain, 1981(Swain, , 1983Dialynas et al, 1983a;Wilde et al, 1983). Therefore, in our experiments, both helper/inducer T cells and cytotoxic/suppressor T cells were important for protection against HV infection.…”

Precursor frequency analysis of lymphokine-secreting alloreactive T lymphocytes. Dissociation of subsets producing interleukin 2, macrophage-activating factor, and granulocyte-macrophage colony-stimulating factor on the basis of Lyt-2 phenotype.

“…Three groups (33)(34)(35) In considering this apparent dissociation, it is important to note that T lymphocytes, and particularly Lyt-2 + cells, have specific membrane receptors for IL-2 (40). Thus, it cannot be excluded that the low apparent frequencies of Lyt-2 + precursors of IL-2-secreting cells observed in this and other studies may result, at least in part, from IL-2 absorption during the culture period.…”

Cell-mediated Immunity to Virus Causing Haemorrhagic Fever with Renal Syndrome: Generation of Cytotoxic T Lymphocytes

“…2 + C', anti-L3T4 + C' or anti-Lyt2.2 + C' showed that the cytotoxic effector cells were T lymphocytes with Lyt2 ÷ L3T4-markers on their surface (Table 3). Since Lyt2 ÷ L3T4-T cells are reported to recognize major histocompatibility complex (MHC) class I antigen (Swain, 1981(Swain, , 1983, these cytotoxic effectors were considered to be T lymphocytes restricted with MHC class I antigen.…”