Significance of late reactions after bronchial challenge with house dust mite.

Warner, John O.

doi:10.1136/adc.51.12.905

Cited by 141 publications

(59 citation statements)

References 25 publications

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“…The features of the infiammatory response are very similar, if not identical, to those of naturally occurring asthma [20]. Treatment that affects the infiammatory component of the allergen-induced response is most effective in controlling the condition.…”

Section: Asthmamentioning

confidence: 91%

The control of allergens of dust mites and domestic pets: a position paper

Colloff

Ayres²,

Carswell

et al. 1992

Clin Experimental Allergy

236

112

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Section: Asthmamentioning

confidence: 91%

The control of allergens of dust mites and domestic pets: a position paper

Colloff

Ayres²,

Carswell

et al. 1992

Clin Experimental Allergy

236

112

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“…The reactions were measured after 20 minutes using a gauge, and weals of 2 mm diameter or greater were recorded as positive. The children had a bronchial provocation test to soluble extracts of D. pteronyssinus, using the method described by Warner (1976 (Table 2).…”

Section: Methodsmentioning

confidence: 99%

House dust mite sensitivity in childhood asthma.

Warner¹,

Price²

1978

Archives of Disease in Childhood

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SUMMARY The clinical features of perennial asthmatic children with a skin or bronchial reaction to the house dust mite (Dermatophagoides pteronyssinus) were compared with those of asthmatic children without mite sensitivity. Mite sensitive asthma was characterised by an early age of onset of symptoms, these being predominantly nocturnal. A history of wheezing precipitated by dust exposure, during vacuuming, bedmaking, or dusting was present in 52% of cases. Asthmatic children with mite sensitivity were more likely to have been born at the time of the year when mite counts were highest. This was consistent with the idea that allergy may be associated with a period of susceptibility to sensitisation in early infancy.Asthma precipitated by exposure to dust has been recognised for three centuries (Van Helmont, 1662), but the link between house dust and house mite allergy in asthmatic patients was not described until 1964 (Voorhorst et al.). Skin tests (MorrowBrown and Filer, 1968), bronchial provocation tests (Aas, 1970), in vitro tests measuring IgE antibodies (Stenius and Wide, 1969), and histamine release from leucocytes (McAllen et al., 1970) have clearly indicated that the mite, Dermatophagoides pteronyssinus, is one of the commonest allergens in Europe to which asthmatic patients are sensitised.Sensitivity to D. pteronyssinus is common in childhood asthma (Sarsfield, 1974) but little has been published on the characteristics of such an allergy. The clinical importance of any one allergy in an asthmatic child with multiple allergen sensitivities can ultimately only be determined by history. There is an impression of an association between nocturnal asthma occurring throughout the year and house mite sensitivity, but this has not been established. Therefore, we have compared aspects of the clinical history of asthmatic children with and without a skin or bronchial reaction to D. pteronyssinus. Patients and methodsEighty-five children (62 boys and 23 girls) with moderate to severe perennial asthma, aged between 5 (the minimum for performing bronchial provocation tests adequately) and 14 years were studied. Received 9 February 1978 Bronchial asthma was diagnosed by clinical and laboratory evidence of intermittent airways obstruction, reversible to a degree by bronchodilators. All the children had at least 6 moderately severe attacks of wheezing each year and their asthma was not satisfactorily controlled on bronchodilators alone.The children were admitted to hospital for at least 48 hours. A full clinical history and examination was recorded on a standard questionnaire. Each had prick skin tests on the forearms to 10 allergens and a control solution. The reactions were measured after 20 minutes using a gauge, and weals of 2 mm diameter or greater were recorded as positive. The children had a bronchial provocation test to soluble extracts of D. pteronyssinus, using the method described by Warner (1976).The medical notes of a further 163 unselected asthmatic children were studied to abstract information on skin t...

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“…A llergen provocation of asthma patients elicits a biphasic response of bronchoconstriction in ϳ60% of subjects, consisting of an early phase reaction (EPR) 3 and a late phase reaction (LPR) (1)(2)(3)(4)(5). The EPR occurs ϳ15 min after allergen provocation and is thought to be mediated by resident leukocytes found in the lung such as mast cells (6).…”

mentioning

confidence: 99%

Early Phase Bronchoconstriction in the Mouse Requires Allergen-Specific IgG

Crosby

Cieslewicz

Borchers

et al. 2002

The Journal of Immunology

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Allergen provocation of allergic asthma patients is often characterized by an initial period of bronchoconstriction, or early phase reaction (EPR), that leads to maximal airway narrowing within 15–30 min, followed by a recovery period returning airway function to baseline within 1–2 h. In this study, we used a defined OVA provocation model and mice deficient for specific leukocyte populations to investigate the cellular/molecular origins of the EPR. OVA-sensitized/challenged wild-type (C57BL/6J) mice displayed an EPR following OVA provocation. However, this response was absent in gene knockout animals deficient of either B or T cells. Moreover, transfer of OVA-specific IgG, but not IgE, before the OVA provocation, was capable of inducing the EPR in both strains of lymphocyte-deficient mice. Interestingly, an EPR was also observed in sensitized/challenged mast cell-deficient mice following an OVA provocation. These data show that the EPR in the mouse is an immunologically based pathophysiological response that requires allergen-specific IgG but occurs independent of mast cell activities. Thus, in the mouse the initial period of bronchoconstriction following allergen exposure may involve neither mast cells nor IgE-mediated events.

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Significance of late reactions after bronchial challenge with house dust mite.

Cited by 141 publications

References 25 publications

The control of allergens of dust mites and domestic pets: a position paper

The control of allergens of dust mites and domestic pets: a position paper

House dust mite sensitivity in childhood asthma.

Early Phase Bronchoconstriction in the Mouse Requires Allergen-Specific IgG

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