Significance of kidney biopsy in autosomal dominant tubulointerstitial kidney disease-UMOD: is kidney biopsy truly nonspecific?

Onoe, Tamehito; Hara, Satoshi; Yamada, Kazunori; Zoshima, Takeshi; Mizushima, Ichiro; Ito, Kiyoaki; Mori, Takayasu; Daimon, Shoichiro; Muramoto, Hiroaki; Shimizu, Masaru; Iguchi, Akira; Kuma, Akihiro; Ubara, Yoshifumi; Mitobe, Michihiro; Tsuruta, Hiroaki; Kishimoto, Nao; Imura, Junko; Konoshita, Tadashi; Kawano, Mitsuhiro

doi:10.1186/s12882-020-02169-x

Cited by 19 publications

(18 citation statements)

References 24 publications

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“… 17 Similarly, a multi-center study from Turkey showed a mortality rate of 16.2%. 18 We found a mortality rate of 25.6% in our study, which is in-between the aforementioned studies. One reason for these differences in mortality in the dialysis population might be an overall difference in COVID-19 mortality rates in these countries within their general population.…”

Section: Discussionsupporting

confidence: 82%

Clinical Course and Outcome of ESRD Patients on Maintenance Hemodialysis Infected with COVID-19: A Single-Center Study

Kazmi¹,

Alam²,

Salman³

et al. 2021

IJNRD

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Background In an ESRD subset of patients, COVID-19 infection is associated with increased disease burden and higher mortality rates. Methods We conducted a retrospective single-center cohort study in which 43 ESRD patients had a diagnosis of COVID-19. Association of risk factors with mortality was assessed by chi-square test and logistic regression analysis. Data were collected on a structured performa which included variables like age, gender, comorbid conditions, drug history, clinical presentation, hemodynamic status and laboratory parameters. Outcome variables were recovery and death. All patients received standard treatment for COVID-19 according to hospital protocols, along with hemodialysis and continuous renal replacement therapy (CRRT) when needed. Results Those most affected were found to be male, 25 (58.1%), while the number of females affected was 18 (41.9%). The most frequent comorbid condition was hypertension (HTN), seen in 35 (81.4%) patients; however, thromboembolic complications were very few in these patients. The mortality rate in our study was 25.6%, and the population most susceptible to poor outcomes in the ESRD subgroup was elderly people (45.5%), while younger patients recovered the most from COVID-19 (53.1%). Hypoalbuminemia, leukocytosis, lymphopenia and raised LDH were also found to be associated with death in ESRD patients suffering from COVID-19 (81.8, 72.7, 100 and 100%, respectively). In multivariate logistic regression analysis, we found that the odds ratio of dying from COVID-19 was 19.5 times higher in patients aged >65 years as compared to patients aged 18–50 years (p=0.039). Similarly, patients with a high TLC were 24.1 times more likely to die than patients with a normal TLC (p=0.008). Conclusion In our center, the mortality rate of ESRD patients affected with COVID-19 disease was 25.6%, and older age, leukocytosis, lymphopenia, hypoalbuminemia and high LDH were significantly associated with mortality.

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Section: Discussionsupporting

confidence: 82%

Clinical Course and Outcome of ESRD Patients on Maintenance Hemodialysis Infected with COVID-19: A Single-Center Study

Kazmi¹,

Alam²,

Salman³

et al. 2021

IJNRD

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“…In research articles reporting clinical manifestation and outcome of COVID-19 patients (78[54.4%]) the diagnosis of SARS-CoV-2 infection relied principally on RT-PCR (52[63.4%]) [ 11 – 20 , 32 , 61 , 62 , 69 , 93 , 94 , 100 , 108 – 111 , 113 , 115 – 124 , 126 , 129 , 132 , 134 , 135 , 138 – 151 ], serology (4[6.3%]) [ 18 , 20 , 22 – 24 , 86 , 99 ], RT-PCR and serological assay (5[6.6%])[ 29 – 31 , 85 , 127 , 152 ] or a combination of diagnostic tests including clinical evaluation [ 6 , 13 , 19 , 21 , 112 , 114 , 125 , 128 , 130 , 131 , 133 , 136 , 137 , 153 , 154 ].…”

Section: Resultsmentioning

confidence: 99%

“…All outcome measures were influenced by the sample size, the age of patients, length of follow-up and policy of healthcare delivery. Excluding studies reporting outcome of patient admitted to hospital as a preventive measure and regardless of symptoms, we found that hospitalization of HD patients varied from 35 to 88.2% [ 11 – 13 , 17 , 21 , 32 , 62 , 82 , 93 , 109 , 114 , 116 , 118 , 120 , 127 , 129 , 133 , 136 – 138 , 144 , 145 , 150 , 154 ]. with a percentage of patients requiring ICU admission of 2.6–70.5% [ 6 , 13 , 17 , 21 , 32 , 62 , 109 , 114 , 116 , 118 , 119 , 121 , 125 , 126 , 129 – 134 , 136 , 138 , 143 , 154 ].…”

Section: Resultsmentioning

confidence: 99%

The frail world of haemodialysis patients in the COVID-19 pandemic era: a systematic scoping review

et al. 2021

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Background Patients undergoing in-centre haemodialysis (HD) are particularly exposed to the dire consequences of COVID-19. The present systematic scoping review aims to identify the extent, range, and nature of articles related to COVID-19 and maintenance HD: it reports specifically the prevalence of the COVID-19 pandemic in the HD population, implementation of strategies for the prevention, mitigation and containment of the COVID-19 pandemic in HD centres, demographic and clinical characteristics, and outcomes of the pediatric and adult HD patients. Methods A multi-step systematic search of the literature in Pubmed, Scopus, Ovid Medline, Embase and Web of Science, published between December 1, 2019, and January 30, 2021 was performed. Two authors separately screened the titles and abstracts of the documents and ruled out irrelevant articles. A report of the papers that met inclusion criteria was performed; then, a descriptive analysis of the characteristics of the included articles and a narrative synthesis of the results were performed. Results The review process ended with the inclusion of 145 articles. Most of them were based on single-centre experiences, which spontaneously developed best practices. Most studies were conducted in high-income countries (69.7%) and a part of them (9.6%) were not in English. Prevalence of COVID-19 among dialysis patients accounted for 0%-37.6%. Preventive measures were reported in 54% of the included articles, with particular emphasis on education, triage, hygiene, and containment measures. Patients experienced a heterogeneous spectrum of symptoms that led 35%-88.2% of them to hospital admission. Median and mean hospital length of stay ranged from 8 to 28.5 and 16.2 to 22 days, respectively. Admission to intensive care units varied widely across studies (from 2.6% to 70.5%) and was associated with high mortality (42.8%-100%). Overall, prognosis was poor in 0%-47% of the hospitalized patients. Conclusions This systematic scoping review provides an overview of the current knowledge on the impact of COVID-19 on the frail world of HD patients. Furthermore, it may help to implement the existing strategies of COVID-19 prevention and provide a list of unmet needs (safe transport, testing, shelter). Finally, it may be a stimulus for performing systematic reviews and meta-analyses which will form the basis for evidence-based guidelines.

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“…During the pathogenesis of DN, numerous genes may subject to expressional alterations in a coordinated manner. Consequently, to describe and understand changes in gene expression profiles, genomic based approaches are needed [ 6 ]. Up to now, a majority of studies have been focused on the differential expression of genes associated with DN, but ignored their high degree of interconnectivity.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of diabetic nephropathy expression profile based on weighted gene co-expression network analysis algorithm

2021

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Background Diabetic nephropathy (DN) is the major complication of diabetes mellitus, and leading cause of end-stage renal disease. The underlying molecular mechanism of DN is not yet completely clear. The aim of this study was to analyze a DN microarray dataset using weighted gene co-expression network analysis (WGCNA) algorithm for better understanding of DN pathogenesis and exploring key genes in the disease progression. Methods The identified differentially expressed genes (DEGs) in DN dataset GSE47183 were introduced to WGCNA algorithm to construct co-expression modules. STRING database was used for construction of Protein-protein interaction (PPI) networks of the genes in all modules and the hub genes were identified considering both the degree centrality in the PPI networks and the ranked lists of weighted networks. Gene ontology and Reactome pathway enrichment analyses were performed on each module to understand their involvement in the biological processes and pathways. Following validation of the hub genes in another DN dataset (GSE96804), their up-stream regulators, including microRNAs and transcription factors were predicted and a regulatory network comprising of all these molecules was constructed. Results After normalization and analysis of the dataset, 2475 significant DEGs were identified and clustered into six different co-expression modules by WGCNA algorithm. Then, DEGs of each module were subjected to functional enrichment analyses and PPI network constructions. Metabolic processes, cell cycle control, and apoptosis were among the top enriched terms. In the next step, 23 hub genes were identified among the modules in genes and five of them, including FN1, SLC2A2, FABP1, EHHADH and PIPOX were validated in another DN dataset. In the regulatory network, FN1 was the most affected hub gene and mir-27a and REAL were recognized as two main upstream-regulators of the hub genes. Conclusions The identified hub genes from the hearts of co-expression modules could widen our understanding of the DN development and might be of targets of future investigations, exploring their therapeutic potentials for treatment of this complicated disease.

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Significance of kidney biopsy in autosomal dominant tubulointerstitial kidney disease-UMOD: is kidney biopsy truly nonspecific?

Cited by 19 publications

References 24 publications

Clinical Course and Outcome of ESRD Patients on Maintenance Hemodialysis Infected with COVID-19: A Single-Center Study

Clinical Course and Outcome of ESRD Patients on Maintenance Hemodialysis Infected with COVID-19: A Single-Center Study

The frail world of haemodialysis patients in the COVID-19 pandemic era: a systematic scoping review

Comprehensive analysis of diabetic nephropathy expression profile based on weighted gene co-expression network analysis algorithm

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