Significance of intrinsic breast cancer subtypes on the long-term prognosis after neoadjuvant chemotherapy

Abstract

BackgroundThe prognosis of breast cancer and the treatment response to neoadjuvant chemotherapy (NAC) differ depending on the intrinsic molecular subtypes. We evaluated the prognostic significance of immunohistological subtypes in patients with recurrent breast cancer after treatment with NAC and surgery.MethodsA total of 237 patients with breast cancer treated with NAC and subsequent curative surgery between 2007 and 2015 were analyzed. The correlation between intrinsic molecular subtypes and clinicopathological features, prognosis, and pathological complete response (pCR) rate of NAC were investigated retrospectively.ResultsThere were 55 (23.2%) patients with recurrence after surgery. No significant difference in post-recurrence survival (PRS) was noted among the subtypes (p = 0.397). In patients with estrogen receptor-positive human epidermal growth factor receptor (HER) 2-negative (luminal) malignancy, PRS was significantly better in the pCR group than in the non-pCR group (p = 0.031). Conversely, pCR was not a significant predictor of improved PRS in patients with triple-negative breast cancer (TNBC; p = 0.329). Multivariate analysis revealed that the efficacy of NAC [hazard ratio (HR) 300.204, p < 0.001] and the initial metastasis site (HR 15.037, p = 0.005) were independent predictors for PRS in patients with luminal breast cancer, while Ki-67 (HR 51.171, p = 0.020) and the initial metastasis site (HR 13.318, p = 0.048) were independent predictors for PRS in patients with TNBC.ConclusionsThe prognostic factors for each intrinsic subtype should be evaluated separately in patients with recurrent breast cancer following NAC and surgery.

Comprehensive analysis of peroxiredoxins expression profiles and prognostic values in breast cancer

“…Classification of intrinsic subclasses is helpful in the prediction of therapeutic response and prognosis of BrCa [19]. So, we next compared the differential transcriptional levels of PRDX family members according to different intrinsic subclasses of BrCa.…”

Impact of Postmastectomy Radiotherapy on Locoregional Control and Disease-Free Survival in Patients with Breast Cancer Treated with Neoadjuvant Chemotherapy

“…Neoadjuvant chemotherapy (NAC) is currently widely used in patients with locally advanced breast cancer to transform nonoperable cases into operable ones, thus improving breast preservation rates and reflecting the sensitivity of tumour cells to systemic therapy [ 1 – 3 ]. A large number of studies have shown that postmastectomy radiotherapy (PMRT) can significantly reduce the locoregional recurrence rate (LRR) of patients with stage II-III breast cancer and increase overall survival (OS) [ 4 , 5 ].…”

Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1

“…ER-positive tumors are further subtyped into low proliferation rate luminal A and higher proliferation rate luminal B tumors. Patients with the triple negative breast cancer (TNBC) subtype, characterized by the absence of ER, progesterone receptor (PR), and human epidermal growth factor receptor-2/neu receptors (HER2/neu) have a poor prognosis [5,6] also due to the few clinical treatments available. Considerable effort has gone into identifying new therapeutic agents, with multiple targeting abilities, able to circumvent the limitation of current conventional therapy.…”