Significance of Hyperamylasaemia and Abdominal Pain in Diabetic Ketoacidosis

Knight, A. H.; Williams, David N.; Ellis, G.; Goldberg, David M.

doi:10.1136/bmj.3.5872.128

Cited by 51 publications

(21 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3][4] However, the incidence of acute pancreatitis in DKA seems to be higher in adults compared with children and is reported to be more than 10%. 5 We also have found that pancreatic enzyme elevations occur much less commonly in the setting of new-onset diabetes without DKA.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic enzyme elevations in children with diabetic ketoacidosis

Haddad

Croffie

Eugster

2004

The Journal of Pediatrics

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Pancreatic enzyme elevations in children with diabetic ketoacidosis

Haddad

Croffie

Eugster

2004

The Journal of Pediatrics

View full text Add to dashboard Cite

“…In an earlier study we concluded that the pancreas was the most likely source of the hyperamylasemia commonly encountered in diabetic ketoacidosis, even though abdominal pain and other clinical stigmata of pancreatitis occurred in such patients no more frequently than in patients with normal serum amylase levels. 18 Neither the degree of initial hyperglycemia or acidosis nor the speed of onset of the metabolic decompensation bore any relationship to the incidence of enzyme abnormalities. Since some of the isolated enzyme abnormalities, especially those concerning ADase activity, occurred at or soon after admission, dehydration was examined as a possible contributing factor.…”

Section: Discussionmentioning

confidence: 98%

Serum Enzyme Changes in Diabetic Ketoacidosis

et al. 1974

View full text Add to dashboard Cite

A study of thirty-six unselected episodes of diabetic ketoacidosis showed that multiple serum enzyme abnormalities, severe in degree, occurred in eleven (30.6 per cent). Seven could be explained wholly or partly by concurrent illness, such as myocardial infarction or gallstones, but no cause could be found in the other four cases. Since multiple enzyme abnormalities of lesser degree occurred without clinical explanation in a further three cases, the over-all incidence of multiple unexplained enzyme elevation was 19.4 per cent. A single serum enzyme activity was elevated over several consecutive samples during nine episodes: CPK was the enzyme concerned in three, and six were associated with abnormalities in enzymes specific for hepatobiliary disorders. The prognosis is seriously affected by concurrent illness, but is not altered by the existence of enzyme abnormalities per se, no matter how severe; these may reflect transient leakage of enzymes from hepatocytes reversibly damaged by lysosomal constituents.

show abstract

“…Though even grossly raised serum amylase levels may not in themselves be associated with increased mortality or morbidity (Knight et al, 1973) all patients with accidental hypothermia and hypothermic myxoedema should have their serum amylase and blood glucose levels measured soon after admission to hospital. Not only will this indicate diabetic ketoacidosis when it is present but raised amylase levels will identify patients likely to develop diabetic ketoacidosis in the ensuing few days.…”

Section: Discuss'ionmentioning

confidence: 99%