Significance of hepatocyte growth factor concentrations in serum of patients with liver cirrhosis and patients with hepatocellular carcinoma

Deen, Heba S El; Haddad, Hemmat El

doi:10.4103/1110-7782.165437

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…In this study, ascitic HGF had a significant positive correlation with both transaminases in SBP. That partially agreed with previous studies e.g a significant positive correlation between serum HGF and transaminases 27 , a positive correlation with AST but not ALT 26, or not at all 28 .…”

Section: Discussionsupporting

confidence: 93%

Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients

Sorour

Ahmed

Marzaban

et al. 2019

Egyptian Journal of Medical Microbiology

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Background: Spontaneous bacterial peritonitis (SBP) is a common and potentially lethal complication of decompensated cirrhosis. Hepatocyte growth factor (HGF) is a protein produced by mesenchymal cells, and regulated by different physiological and pathological conditions e.g pregnancy, aging and infections. Objective: This study evaluated ascitic HGF as a local marker in diagnosis of SBP. Methodology: Eighty cirrhotic ascitic patients were divided equally into 40 patients with SBP and 40 without. All involved patients were subjected to assay of ascitic HGF using ELISA technique. Results: Ascitic HGF was significantly related to SBP (P=0.000). The sensitivity and specificity of HGF for differentiating SBP were 80 and 82.5%, respectively, at a cut-off value of 2981.34 pg/ml. There was a significant positive correlation between ascitic HGF and TLC (P=0.018), and transaminases; AST and ALT (P =0.007 and P=0.023 respectively). Conclusion: Ascitic HGF is a reliable minimally invasive biomarker for diagnosis of SBP in cirrhotic patients.

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Section: Discussionsupporting

confidence: 93%

Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients

Sorour

Ahmed

Marzaban

et al. 2019

Egyptian Journal of Medical Microbiology

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“…We conclude from this study that both HGF and AFP can be additional useful factors as noninvasive biomarkers for the early detection of HCC in cirrhotic patients and this agree with that was found by S. El Deen and El Haddad [20].…”

Section: Discussionsupporting

confidence: 92%

Predictors of Recurrence of Hepatocellular Carcinoma after Transarterial Chemoembolization: Role of Hepatocyte Growth Factor

Zaghloul¹,

Sedky²,

Mohammed³

et al. 2020

OJGas

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Background: Hepatocellular carcinoma is the third leading cause of tumor related mortality and develops mostly in patients with chronic liver disease and liver cirrhosis. Human hepatocyte growth factor (HGF) is produced in various organs of the body and is characterized as a multifunctional factor with various biologic activities. Aim: Our aim was to investigate the predictive factors of recurrence specially the role of HGF in patients with HCC treated with TACE. Patients and Methods: one hundred HCC patients treated by TACE who achieved complete response were included and divided into two groups according to disease free survival (DFS) status at 1 year: the non-early recurrence (NER) group (1) and the early recurrence (ER) group (2). Univariate binary logistic regression analysis for the possible risk factors of recurrence showed that AFP, multinodularity and HGF level were significant. Conclusion: high AFP, multinodularity and high HGF were inter-related possible risk factors for 1-year recurrence of HCC in patients with initial remission following TACE.

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Significance of hepatocyte growth factor concentrations in serum of patients with liver cirrhosis and patients with hepatocellular carcinoma

Cited by 2 publications

References 34 publications

Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients

Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients

Predictors of Recurrence of Hepatocellular Carcinoma after Transarterial Chemoembolization: Role of Hepatocyte Growth Factor

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