“…Examining nonsequential karyotypes, several investigators have inferred that karyotypic changes occurring in the presence of more frequently identified abnormalities in N H L are evolutionary in nature. In these studies, usually conducted in patients with follicular lymphomas, the "evolutionary" cytogenetic abnormalities frequently involve chromosomes 6, 7, and 18, although a number of other chromosomes and regions have also been implicated (Richardson eta]., 1987;Yunis et al, 1987;Armitage et al, 1988;Fukuhara et al, 1988). Only one other study has specifically addressed karyotypic changes among sequential biopsies in N H L ; like our own series, additional structural abnormalities of chromosome 1 were commonly identified, but no specific band or region of chromosome 1 was repeatedly affected (Sanger et al, 1987).…”