Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study

Miyake, Teruki; Kumagi, Teru; Hirooka, Masashi; Furukawa, Shinya; Kawasaki, Keitarou; Koizumi, Masaru; Todo, Yasuhiko; Yamamoto, Shin; Nunoi, Hiroaki; Terada, Yoshio; Ikeda, Yoshio; Abe, Masanori; Kitai, Kohichiro; Matsuura, Bunzo; Hiasa, Yoichi

doi:10.1007/s00535-014-0959-6

Cited by 21 publications

(13 citation statements)

References 25 publications

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“…Nonalcoholic fatty liver disease is the presence of excessive fat in the liver, demonstrated by imaging modalities, such as transabdominal ultrasound, computerized tomography, and magnetic resonance imaging (3)(4)(5). It is also a diagnosis of exclusion.…”

Section: Nafld: Definitions Prevalence and Related Factorsmentioning

confidence: 99%

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Nonalcoholic fatty liver disease: Diagnosis, pathogenesis, and management

Başaranoğlu

Örmeci²

2014

Turk J Gastroenterol

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Nonalcoholic fatty liver disease (NAFLD) is an umbrella term that covers both a relatively benign condition, which is simple steatosis, and nonalcoholic steatohepatitis (NASH). NASH is characterized by a chronic and progressive liver pathology that may progress to cirrhosis, end-stage liver disease, hepatocellular carcinoma, and liver transplantation. Despite the growing body of evidence, one of the important and unresolved problems is the pathogenesis of NASH. It might be a metabolic disturbance as a primary abnormality in NAFLD. Insulin resistance is at the center of these metabolic abnormalities. Then, hepatocyte injury might be induced by oxidative stress. This ongoing process progresses to NASH, even to cirrhosis in some patients. In addition to oxidative stress, possibilities for the next hit are lipid peroxidation, reactive metabolites, adipose tissue products, transforming growth factor-b 1 , Fas ligand, mitochondrial dysfunction, respiratory chain deficiency, and intestinal microbiota. Currently, there is no well-established and approved therapy. Recommendations are to improve existing co-morbidities, such as obesity, hyperlipidemia, or type 2 diabetes, and lifestyle modification with weight loss and exercise.

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Section: Nafld: Definitions Prevalence and Related Factorsmentioning

confidence: 99%

“…Nonalcoholic fatty liver disease (NAFLD) defines a spectrum of histological abnormalities, from simple fatty liver to nonalcoholic steatohepatitis (NASH), in a person consuming no alcohol (1)(2)(3)(4)(5)(6) (Table 1). NAFLD is a part of the metabolic syndrome, particularly in obesity, hyperlipidemia, and diabetes.…”

Section: Introductionmentioning

confidence: 99%

Nonalcoholic fatty liver disease: Diagnosis, pathogenesis, and management

Başaranoğlu

Örmeci²

2014

Turk J Gastroenterol

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“…Nonalcoholic fatty liver disease (NAFLD) defines a spectrum of histological abnormalities, from simple fatty liver to nonalcoholic steatohepatitis (NASH), in a person consuming no alcohol (9,10,11). The main element of NAFLD is the accumulation of triglycerides (TG) as fat droplets within the cytoplasm of hepatocytes, which is a prerequisite for subsequent events of NASH, as more than 5%-10% of hepatocytes have fat droplets, as evident on liver biopsy (10).…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of NASH related cirrhosis and hepatocellular carcinoma (HCC) is also high among patients with diabetes, as in obesity (13,14,16). As a risk factor, hypertriglyceridemia is also associated with insulin resistance and NAFLD, even in patients without obesity (11,23).…”

Section: Discussionmentioning

confidence: 99%

Association and impact of non-alcoholic fatty liver disease on thyroid function

2017

Int. J. Curr. Res. Med. Sci.

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Nonalcoholic fatty liver disease (NAFLD) means accumulation of fat mainly triglyceride exceeding 5 % of liver weight, affecting approximately 20% of population in developed countries. Thyroid dysfunction have been frequently associated with non-alcoholic fatty liver disease. The aim of this study is to determine any association between nonalcoholic fatty liver disease and thyroid dysfunction and to evaluate the impact of non-alcoholic fatty liver disease on thyroid function tests. Subjects and methods: This study was carried out on sixty adult men and women with nonalcoholic fatty liver disease and sixty age-and sex-matched males and females without the disease. NAFLD patients were subjected to a full assessment of medical history, physical examination, abdominal ultrasonography as well as routine laboratory tests. Patients and controls underwent liver function and thyroid function testing including thyroid antibodies. Results: Thirteen patients with NAFLD (21.7%) were found to have thyroid dysfunction. The most common thyroid dysfunction was subclinical hypothyroidism which was found in 10 (16.7%) NAFLD patients followed by overt hypothyroidism in 3 patients (5%). There were statistically significant difference between patients and controls as regard to TSH (p=0.0001), FT4 (p=0.005), FT3 (P=0.043), anti-TPO (p=0.047), anti-TG (p=0.001), IR (p=0.024), insulin (p=0.002), and Leptin (p=0.002). TSH concentration was significantly correlated with ALT (r= 0.381), GGT (r=0.354), HbA1C (r=0.288), triglyceride (r=0.368), FT4 (r=0.414), FT3(r=0.231), anti-TPO(r=0.298), serum insulin (r= 0.287), insulin resistance (IR) (r= 0.453), and serum Leptin (r=0.360) levels.In our patients, hepatic steatosis in the form of increased liver echogenecity was present in almost all patients (100%), and hepatomegaly in twenty-four patients (40%). Thus. Hepatic steatosis were correlated significantly with ALT, GGT, HbA1C, triglyceride, HDL-C, TSH, FT4, FT3, anti-TPO, anti-TG, serum insulin, insulin resistance (IR), and serum Leptin. Conclusion: Thyroid dysfunctions are common in NAFLD patients, with subclinical hypothyroidism hypothyroidism being the most prevalent one. Hepatic steatosis has shown an evident positive correlation with elevated TSH as well as thyroid autoantibodies.

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“…3 A communitybased cross-sectional study indicated that regular exercise was associated with a reduced risk of NAFLD. 8 The primary approach to treating NAFLD is the control of underlying risk factors (e.g. diabetes, hyperlipidemia, obesity and other comorbidities), and lifestyle modification through physical activity and dietary habits is a wellestablished therapeutic strategy.…”

Section: Introductionmentioning

confidence: 99%

<p>A Pilot Study Assessing the Possible Combined Effect of Physical Activity and <em>PNPLA3</em> rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population</p>

Oniki¹,

Kudo²,

Obata³

et al. 2020

DMSO

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The patatin-like phospholipase domain containing protein 3 (PNPLA3) rs738409 polymorphism (c.444C>G) is the most well-known genetic risk factor for non-alcoholic fatty liver disease (NAFLD), but whether or not physical activity influences the association between the PNPLA3 genotype and risk of NAFLD is unclear. Patients and Methods: A retrospective longitudinal analysis was conducted among 352 Japanese subjects. Each type of physical activity was assigned a metabolic equivalent (MET), and the subjects were classified into sedentary, low or high groups using the "METS*T" (METs × hours per week) value of 5 or 21 as a threshold. Results: Among the PNPLA3 G/G genotype carriers, the high and low METS*T groups had a lower risk of NAFLD than the sedentary METS*T group (odds ratio [95% confidence interval]: 0.14 [0.02-0.99] and 0.16 [0.03-1.04], respectively). Furthermore, the PNPLA3 C/C or C/G genotype carriers showed no significant difference in the risk of NAFLD among the three METS*T groups. Conclusion: The PNPLA3 rs738409 genotype may be associated with the beneficial effects of physical activity on the risk of NAFLD among elderly Japanese individuals. Further comprehensive investigations are therefore needed to verify the preliminary results.

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Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study

Cited by 21 publications

References 25 publications

Nonalcoholic fatty liver disease: Diagnosis, pathogenesis, and management

Nonalcoholic fatty liver disease: Diagnosis, pathogenesis, and management

Association and impact of non-alcoholic fatty liver disease on thyroid function

<p>A Pilot Study Assessing the Possible Combined Effect of Physical Activity and <em>PNPLA3</em> rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population</p>

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