Significance of epithelial cell clusters in pseudomyxoma peritonei

Badyal, Rama Kumari; Khairwa, Anju; Rajwanshi, Arvind; Nijhawan, Raje; Srinivasan, Radhika; Gupta, Nalini; Dey, Pranab

doi:10.1111/cyt.12331

Cited by 8 publications

(19 citation statements)

References 28 publications

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“…The nuclear atypia grade was evaluated based on the size of the nuclei. Low‐grade atypia is characterized by small and regular nuclei, while high‐grade atypia is characterized by large and irregular nuclei with occasional, conspicuous nucleoli, based on previous reports . The presence of signet ring cells was also evaluated.…”

Section: Methodsmentioning

confidence: 99%

“…It most often arises from the appendix, and more rarely from the ovary, colon, and urachus . Because of their rarity, the cytological features of PMP have seldom been reported . The characteristic cytological features of the ascites in patients with PMP are the presence of abundant thick mucus material with or without epithelial cell clusters.…”

Section: Introductionmentioning

confidence: 99%

“…The characteristic cytological features of the ascites in patients with PMP are the presence of abundant thick mucus material with or without epithelial cell clusters. The incidences of epithelial cell clusters vary; some investigators have reported no such clusters while more recent studies have revealed a relatively high frequency (approximately 90%) of epithelial cell clusters in patients with PMP …”

Section: Introductionmentioning

confidence: 99%

“…The prognostic significance of the presence of epithelial cell clusters in the cytological specimens of the ascites of patients with PMP is unclear. Data from the few studies that have addressed this issue suggested that the presence of epithelial cell clusters was associated with recurrence, while acellular mucin was related to a more favorable prognosis . However, these studies consisted of a relatively small number of patients, and a large case study to investigate this question has not been performed.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of the presence of epithelial cell clusters in the ascites of patients with pseudomyxoma peritonei

Ishida

Mizumoto²,

Yonemura³

et al. 2019

Diagnostic Cytopathology

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Background Pseudomyxoma peritonei (PMP) is a rare condition characterized by intraperitoneal accumulation of mucus due to mucinous neoplasia. The characteristic cytological feature of PMP in the ascites is abundant mucus with or without epithelial cell clusters. However, the prognostic significance of the presence of epithelial cell clusters has not been determined. This study aimed to determine the prognostic significance of epithelial cell clusters in the ascites of patients with PMP. Methods Patients who were clinically and histopathologically diagnosed with PMP and who underwent intraoperative cytological examination of their ascites were included in this study. Cytological characteristics including mucus and epithelial cell clusters, nuclear atypia, and the presence of signet ring cells were investigated. Overall survival was compared based on the presence of epithelial cell clusters or nuclear atypia. Results A total of 283 patients (199 women and 84 men) were investigated. The most common original site was the appendix (244 patients). Ninety patients (31.8%) had mucus without epithelial cell clusters (acellular mucin) while 193 (68.2%) had mucus with such clusters; 134 (69.4%) and 44 (22.8%) of these patients showed low‐grade and high‐grade nuclear features, respectively. Signet ring cells were detected in 15 patients (7.8%). The presence of epithelial cell clusters did not influence overall survival (P = .28); however, high‐grade nuclear features and signet ring cell presence were significant negative prognostic factors (P < .001). Conclusion The presence of high‐grade nuclear features or of signet ring cells should be carefully investigated in the cytological specimens of patients with PMP.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of the presence of epithelial cell clusters in the ascites of patients with pseudomyxoma peritonei

Ishida

Mizumoto²,

Yonemura³

et al. 2019

Diagnostic Cytopathology

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“…35 A relative increase in single cells in comparison to benign and borderline lesions may be observed. 97 Metastatic mucinous neoplasms that may be encountered in the ovary include metastatic endocervical adenocarcinoma, colorectal adenocarcinoma, low-grade appendiceal mucinous neoplasms, and pancreatobiliary carcinoma. 62 It is prudent to rule out a metastasis of a mucinous tumor to the ovary or peritoneum in cases of mucinous neoplasms.…”

Section: Ovarian Mucinous Neoplasmsmentioning

confidence: 99%

Abdominopelvic washings in gynecologic pathology: A comprehensive review

Schulte

Lastra

2016

Diagnostic Cytopathology

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Abdominopelvic washings (APW) performed during gynecologic surgeries have become a common specimen evaluated by cytopathologists. Their role in staging of female genital tract tumors has changed significantly since they were first described, and continue to evolve. The ability of these washings to detect microscopic disease, even in the absence of gross disease, warrants the critical role that these washings play in the staging of certain female gynecologic tract tumors, allowing for optimal staging and subsequent treatment of the patient. Irrespective of the underlying pathology, the gamut of cytomorphologic findings that may be observed in APW is extensive, and ranges from benign lesions that may act as mimickers of malignancy, to both common and rare malignancies. This review discusses the changing role of APW in the staging of gynecologic tumors, and highlights the salient cytomorphologic features of these lesions, with emphasis in their correct identification, including cautionary notes to avoid over or misinterpretation. Diagn. Cytopathol. 2016;44:1039-1057. © 2016 Wiley Periodicals, Inc.

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A nomogram prediction model of pseudomyxoma peritonei established based on new prognostic factors of HE stained pathological images analysis

Ma,

Su,

Yan

et al. 2024

Cancer Medicine

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BackgroundPseudomyxoma peritonei (PMP) is a rare clinical malignant syndrome, and its rarity causes a lack of pathology research. This study aims to quantitatively analyze HE‐stained pathological images (PIs), and develop a new predictive model integrating digital pathological parameters with clinical information.MethodsNinety‐two PMP patients with complete clinic‐pathological information, were included. QuPath was used for PIs quantitative feature analysis at tissue‐, cell‐, and nucleus‐level. The correlations between overall survival (OS) and general clinicopathological characteristics, and PIs features were analyzed. A nomogram was established based on independent prognostic factors and evaluated.ResultsAmong the 92 PMP patients, there were 34 (37.0%) females and 58 (63.0%) males, with a median age of 57 (range: 31–76). A total of 449 HE stained images were obtained for QuPath analysis, which extracted 40 pathological parameters at three levels. Kaplan–Meier survival analysis revealed eight clinicopathological characteristics and 20 PIs features significantly associated with OS (p < 0.05). Partial least squares regression was used to screen the multicollinearity features and synthesize four new features. Multivariate survival analysis identified the following five independent prognostic factors: preoperative CA199, completeness of cytoreduction, histopathological type, component one at tissue‐level, and tumor nuclei circularity variance. A nomogram was established with internal validation C‐index 0.795 and calibration plots indicating improved prediction performance.ConclusionsThe quantitative analysis of HE‐stained PIs could extract the new prognostic information on PMP. A nomogram established by five independent prognosticators is the first model integrating digital pathological information with clinical data for improved clinical outcome prediction.

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Significance of epithelial cell clusters in pseudomyxoma peritonei

Abstract: On cytomorphology, high-grade tumours were more cellular and frequently showed EC clusters with moderate to severe atypia, prominent nucleoli and mitosis, and were more prone to PMCA.

Cited by 8 publications

References 28 publications

Prognostic significance of the presence of epithelial cell clusters in the ascites of patients with pseudomyxoma peritonei

Prognostic significance of the presence of epithelial cell clusters in the ascites of patients with pseudomyxoma peritonei

Abdominopelvic washings in gynecologic pathology: A comprehensive review

A nomogram prediction model of pseudomyxoma peritonei established based on new prognostic factors of HE stained pathological images analysis

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