Significance of eosinophil and mast cell counts in rectal mucosa in ulcerative colitis

Sarin, S.K.; Malhotra, Veena; Gupta, Saroj; Karol, Agnieszka; Gaur, Sunanda; Anand, B S

doi:10.1007/bf01296289

Cited by 78 publications

(47 citation statements)

References 10 publications

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“…Increased eosinophil numbers have previously been found in association with eosinophilic gastroenteritis, celiac disease, inflammatory bowel diseases, drug-induced colitis, acute gastrointestinal radiation injury, eosinophilic cryptitis, and autoimmune disorders (17,19,20,22,23). In previous histological studies of the bowel in IBD patients the authors reached the general conclusion that mast cell and eosinophil numbers were increased and showed evidence of activation in diseased tissues (25)(26)(27)(28). More recently, other authors concluded that focal eosinophilic mucosal infiltration in CD is more common than epithelioid cell granulomas and emerges as an important parameter in the histologic differential diagnosis between colonic CD and UC (29).…”

Section: Discussionmentioning

confidence: 92%

Evaluation of Mucosal Eosinophils in the Pediatric Colon

et al. 2005

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To evaluate the clinical significance of colonic eosinophilia, we conducted a retrospective study of all children older than 1 year evaluated at Children's Hospital of Pittsburgh from January 1999 to June 2001 with a description of colonic eosinophilia in the pathology report. Medical records were reviewed. Diagnoses were confirmed by contacting the patients. Histological slides (H&E) were reviewed by an investigator blind to the patients' data. Biopsies were grouped according to the site they were taken from and then screened at low power for areas of maximal eosinophilia for further quantitative analysis. Results of manual counts were validated by image analysis using Metaphor Image Analysis Software. Sixty-nine children with colonic eosinophilia were identified (36 male; mean age, 135.2 +/- 55.4 months). Their final diagnoses were inflammatory bowel disease in 32% (group A), irritable bowel syndrome in 33% (group B), food allergies in 10% (group C), and other diagnoses in 25% (group D). The maximal eosinophil count per crypt area was significantly (P < 0.05) higher in group A vs groups B, C, and D (34.8 +/- 17.1 vs 21.3 +/- 8.8, 25.4 +/- 16.7, and 24.2 +/- 9.7, respectively). The total cellularity of the lamina propria was considered high only in group A (P < 0.05 vs groups B and C). A mostly equal vertical distribution of eosinophils throughout the lamina propria was found significantly more frequently in group A vs groups C (P = 0.04) and D (P = 0.007). We conclude that children with inflammatory bowel disease have an equal distribution of eosinophils throughout the lamina propria, with intraepithelial and intracryptal eosinophils and with a higher overall total cellularity. In irritable bowel syndrome and patients with a variety of other diagnoses, including allergies, the distribution is mostly superficial, with a lower total cellularity.

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Section: Discussionmentioning

confidence: 92%

Evaluation of Mucosal Eosinophils in the Pediatric Colon

et al. 2005

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“…However, the causative relationship between development of IBD and mast cell activation or increase in number has not been completely clarifi ed [13]. An elevated number of mast cells and increased mast cell degranulation have been frequently observed in the bowel mucosa of IBD patients [14][15][16][17][18][19]; however, other studies failed to fi nd increased mast cell number [20,21] or reported a decrease [22][23][24]. The discrepancies might arise from differences in measurement techniques (tissue fi xation, staining, cell counting) or to differences in patients characteristics (active disease, remission, drug treatment) [13].…”

Section: Introductionmentioning

confidence: 99%

Long-term study of TNBS-induced colitis in rats: Focus on mast cells

et al. 2006

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“…Additional evidence of mast cell activation in IBD is provided by reports describing increased levels of histamine in rectal dialysates of patients with ulcerative colitis and in jejunal secretions of patients with Crohn's disease compared with controls. Histologic studies do not show uniform changes, and demonstrate increased [27,28], decreased [29], or normal [30] numbers of mucosal mast cells in biopsies from patients with IBD. The challenge of identifying mast cells in the gut occurs due to 1) variable distribution of mast cells in the intestine, 2) technical difficulties with histochemical techniques, and 3) the challenge of identifying degranulated mast cells.…”

Section: Mast Cells In Inflammatory Bowel Diseasementioning

confidence: 88%

The role of mast cells in common gastrointestinal diseases

Siddiqui

Miner

2004

Curr Allergy Asthma Rep

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The gastrointestinal tract is a rich source of mast cells with an enormous surface area that permits a high degree of interaction between the mast cell and the intestinal contents. The active metabolic products of the mast cell influence gastrointestinal secretion, absorption, and motility through paracrine effects of local mast cell activation and also cause systemic effects through the release of cellular products into the bloodstream. Recent advances in our knowledge of the immune system and the recognition that the gastrointestinal immune function might be partially mediated through gastrointestinal mucosal mast cells has opened mast cell research to the field of gastroenterology. Local gastrointestinal proliferation of mast cells in response to recognized or obscure stimuli can alter gastrointestinal function and induce systemic symptoms. Symptoms can arise from the increased number of mast cells, overproduction of specific mast cell mediators, and hyperactivity of the enteric nervous system that induces mast cell activation. The diseases mentioned in this review represent a small proportion of areas where mast cell function might play an important role in the response to disease and generation of symptoms.

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Significance of eosinophil and mast cell counts in rectal mucosa in ulcerative colitis

Cited by 78 publications

References 10 publications

Evaluation of Mucosal Eosinophils in the Pediatric Colon

Evaluation of Mucosal Eosinophils in the Pediatric Colon

Long-term study of TNBS-induced colitis in rats: Focus on mast cells

The role of mast cells in common gastrointestinal diseases

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