Significance of echocardiographic right ventricular predictors of adverse prognosis in right ventricular dysfunction in patients with HFrEF

Abstract

Funding Acknowledgements Type of funding sources: None. Background Dysfunction of the RV in patients with HFrEF is a prognostically unfavorable factor, which depends on the etiology, the duration of myocardial damage and the tactics of the treatment (Pharmacotherapy, Heart Surgery, CRTD, Heart Transplantation). RV function in patients with HFrEF realized in the concept of continuous contraction of the muscle tape proposed by Torrent-Guasp, where systolic and diastolic interventricular interactions are carried out through the common IVS and implemented in the degree of dyssynchrony of ventricular contraction. 3DERV and STE (GLSRV, FWLS) may add the prognostic value of the more commonly used RV functional parameters as the sensitive echocardiographic predictors of worse prognosis in patients with HFrEF. Methods and Results A total of 79 patients with HFrEF (age, from 26 to 77 years; the clinical manifestations of HFrEF corresponded to NYHA III in 52 patients (71%), NYHA IV in 27 patients (29%); LV EF ≤ 35%). The etiology of HFrEF was mainly connected to patients with ischemic heart disease- 50 (63.2%), non-ischemic genesis 29 (36, 7%).The primary endpoint was a death in the follow-up period of up to 3 years in 33 patients (45,2%). An adverse outcomes and mortality during the first year was 17 (23,2%). All patients were divided into subgroups 1 (n = 40) - survived during the 3-year, subgroups 2 (n = 33) - died during the 3-year follow-up period. The presence of RV dysfunction in patients with HFrEF was independently associated with concomitant LV dysfunction but not with PASP (PASP/GLSLV, % (р=0,94), PASP/FWLS RV, % (р=0,97). RV contractility was realized through systolic and diastolic ventricular interactions, mediated through the shared IVS. This putative mechanism was supported by the independent association between septal S’ and S (HR - 1,12; 95%; Cl 0,99-1,26; p = 0,049), GLS BS LV, % и FWLS BS RV, % (HR - 0,90; 95%; Cl 0,79-1,00; p = 0,040). Kaplan–Meier plot, RVFWS > -15%, (χ2 – 4,438; р < 0,035), GLS >-10%, (χ2 – 3,796; р< 0,05), RVBSLS >-15%, (χ2 – 11,986; р = 0,0005), 3DERVEF <25% (χ2 – 7,518; р = 0,006), %CVCI <30% (χ2 – 7,85; р = 0,005), 3DE RAV > 100 ml (χ2 – 4,36; р = 0,036) were an independent predictors of worse prognosis in patients with HFrHF. The curves of the ROC analysis demonstrated a sensitivity of GLSRV - 80.7% as a prognostic factor of survival in patients with HrEF. At the same time, FWLS RV had a specificity (87.5%) compared to GLSRV, %, the longitudinal deformation of the isolated segments of the FWRV, FAC, %VCI collapse, ESDA/SA of RV, RAV. Conclusions RV systolic dysfunction is a strong and independent predictor of in HFrEF. In case of HFrEF the longitudinal mechanism of RV reduction is more sensitive than others. GLSRV, FWS RV, 3DRVEF, %VCI collapse has been proposed as a more accurate and sensitive tool to evaluate RV function in longitudinal displacement of patients with HFrEF. Abstract Figure. Kaplan–Meier plot GLS, 3DEEFRV, FWLS Abstract Figure. ROC analysis