Significance of DopEcR, a G-protein coupled dopamine/ecdysteroid receptor, in physiological and behavioral response to stressors

Petruccelli, Emily; Lark, Arianna R.S.; Mrkvicka, James A; Kitamoto, Toshihiro

doi:10.1080/01677063.2019.1710144

Cited by 25 publications

(17 citation statements)

References 126 publications

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“…4a,d). The DopEcR mutant flies are less sensitive to ethanol sedation 66,67 , and show defects in dealing with various stressors such as starvation, heat and sexual rejection [68][69][70] . Therefore, DopEcR might mediate aversive effects of drugs, which include ethanol sedation, thereby function as a 'brake' for the further drug intake.…”

Section: Discussionmentioning

confidence: 99%

Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila

Kanno

Hiramatsu

Kondo

et al. 2021

Sci Rep

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Dysregulated motivation to consume psychoactive substances leads to addictive behaviors that often result in serious health consequences. Understanding the neuronal mechanisms that drive drug consumption is crucial for developing new therapeutic strategies. The fruit fly Drosophila melanogaster offers a unique opportunity to approach this problem with a battery of sophisticated neurogenetic tools available, but how they consume these drugs remains largely unknown. Here, we examined drug self-administration behavior of Drosophila and the underlying neuronal mechanisms. We measured the preference of flies for five different psychoactive substances using a two-choice feeding assay and monitored its long-term changes. We found that flies show acute preference for ethanol and methamphetamine, but not for cocaine, caffeine or morphine. Repeated intake of ethanol, but not methamphetamine, increased over time. Preference for methamphetamine and the long-term escalation of ethanol preference required the dopamine receptor Dop1R1 in the mushroom body. The protein level of Dop1R1 increased after repeated intake of ethanol, but not methamphetamine, which correlates with the acquired preference. Genetic overexpression of Dop1R1 enhanced ethanol preference. These results reveal a striking diversity of response to individual drugs in the fly and the role of dopamine signaling and its plastic changes in controlling voluntary intake of drugs.

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Section: Discussionmentioning

confidence: 99%

Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila

Kanno

Hiramatsu

Kondo

et al. 2021

Sci Rep

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“…Since there are no adrenal glands in insects, the corresponding secondary hormones are not known in insects. Perhaps octopamine (OA) and dopamine (DA), as well as Ecd and JH, are part of the stress signaling downstream of DILPs and CRZ (Gruntenko et al 2016 ; Gruntenko et al 2005 ; Gruntenko et al 2010 ; Lubawy et al 2020 ; Petruccelli et al 2020 ; Roeder 2020 ; Zhao et al 2010 ). Thus, the cellular sources of insect stress factors are in adults spread out into CA (JH), sets of neurons (OA, DA) and gonads (Ecd).…”

Section: Do Insect Neurosecretory Cell Systems Share Functions With Tmentioning

confidence: 99%

Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions

Nässel

Zandawala

2020

Cell Tissue Res

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Hormones regulate development, as well as many vital processes in the daily life of an animal. Many of these hormones are peptides that act at a higher hierarchical level in the animal with roles as organizers that globally orchestrate metabolism, physiology and behavior. Peptide hormones can act on multiple peripheral targets and simultaneously convey basal states, such as metabolic status and sleep-awake or arousal across many central neuronal circuits. Thereby, they coordinate responses to changing internal and external environments. The activity of neurosecretory cells is controlled either by (1) cell autonomous sensors, or (2) by other neurons that relay signals from sensors in peripheral tissues and (3) by feedback from target cells. Thus, a hormonal signaling axis commonly comprises several components. In mammals and other vertebrates, several hormonal axes are known, such as the hypothalamic-pituitary-gonad axis or the hypothalamic-pituitary-thyroid axis that regulate reproduction and metabolism, respectively. It has been proposed that the basic organization of such hormonal axes is evolutionarily old and that cellular homologs of the hypothalamic-pituitary system can be found for instance in insects. To obtain an appreciation of the similarities between insect and vertebrate neurosecretory axes, we review the organization of neurosecretory cell systems in Drosophila. Our review outlines the major peptidergic hormonal pathways known in Drosophila and presents a set of schemes of hormonal axes and orchestrating peptidergic systems. The detailed organization of the larval and adult Drosophila neurosecretory systems displays only very basic similarities to those in other arthropods and vertebrates.

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“…In the gypsy moth Lymantria dispar , for example, larval crowding results in a decreased concentration of the hormone dopamine in the hemolymph ( Pavlushin et al 2019 ). In Drosophila , crowding induces heat shock proteins (reviewed by King and MacRae 2015 ) and affects the dopamine/ecdysteroid receptor that modulates intracellular signaling pathways in response to various stressors (reviewed by Petruccelli et al 2020 ). In locusts, higher population density causes solitary-to-gregarious phase transformation, and many internal regulatory chemical agents and signal molecules are known to play a role (reviewed by Ayali 2019 ).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Population Density on the Incidence of Developmental Deformities in Chemosensory Organs of Tobacco Hornworm Larvae (Lepidoptera: Sphingidae)

Hanson

Stanwyck

Bohorquez

2020

Journal of Insect Science

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Cultures of Manduca sexta Johanssen in our laboratory were found to have larvae with missing or deformed mouthparts or antennae. Hypothesizing that these developmental deformities were caused by crowded rearing conditions, we reared larvae in four different population densities and recorded the incidence (% of larvae affected) and types of chemoreceptor deformities. Results showed that the incidence of these deformities was directly proportional to larval population density. Deformities of the maxilla and palp were the most frequent, followed by those of the antenna, epipharynx and maxillary styloconica. Life history traits of larval mass, food consumption, and rate of development were inversely related to larval density for both normal and deformed larvae. We discuss possible causes and mechanisms of these deformities and of changes to life history traits.

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Significance of DopEcR, a G-protein coupled dopamine/ecdysteroid receptor, in physiological and behavioral response to stressors

Cited by 25 publications

References 126 publications

Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila

Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila

Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions

The Effects of Population Density on the Incidence of Developmental Deformities in Chemosensory Organs of Tobacco Hornworm Larvae (Lepidoptera: Sphingidae)

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