Significance of detecting anti-HBc among Egyptian male blood donors negative for HBsAg*

Antar, W.; El-Shokry, Mona; Hamid, W. A. Abd El; Helmy, Mai

doi:10.1111/j.1365-3148.2010.01021.x

Cited by 39 publications

(26 citation statements)

References 22 publications

(35 reference statements)

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“…The higher OBI rate in the latter study may be attributed to the small sample size. The prevalence of OBI among Egyptian blood donors positive for antiHBc (6.25-17.2%) is higher than that reported among HCWs in our study (17)(18)(19).…”

Section: Discussioncontrasting

confidence: 78%

Occult hepatitis B infection in Egyptian health care workers

Elmaghloub¹,

Didamony²,

Hashim³

et al. 2017

East Mediterr Health J

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We tested the frequency of occult hepatitis B infection (OBI) among Egyptian healthcare workers (HCWs). We tested 132 HCWs for hepatitis B virus (HBV) DNA by nested polymerase chain reaction (PCR), and hepatitis C virus antibody (anti-HCV) by ELISA. HCV RNA was measured by nested PCR in anti-HCV-positive HCWs. HBV-DNA-positive HCWs were subjected to HBV genotyping. We included 132 HCWs who were negative for hepatitis B surface antigen and positive for hepatitis B core antibody (anti-HBc). OBI was detected in 7 male HCWs, and HBV E genotype was detected in 3, HBV D in 2 and HBV D and E in 2. Two OBI-positive HCWs had a history of neonatal hepatitis B vaccination. Anti-HCV seropositivity was detected in 17 HCWs who were positive for anti-HBc; 15 of whom were positive for HCV RNA by nested PCR. HCV infection was confirmed by anti-HCV and HCV RNA in 1 of 7 HCWs with OBI. In conclusion, Egyptian HCWs have a significant rate of OBI and HBV E genotype is prevalent. ‫مرص‬

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Section: Discussioncontrasting

confidence: 78%

Occult hepatitis B infection in Egyptian health care workers

Elmaghloub¹,

Didamony²,

Hashim³

et al. 2017

East Mediterr Health J

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“…This enormous variation in anti-HBc prevalence reflects the differences in HBV endemicity among these countries [14]. More attention should be paid to the anti-HBc prevalence rate among countries suffering from HBV infection such as Syria (which has an HBsAg prevalence rate of 5.62%) [2], particularly because anti-HBc positivity represents a risk of HBV transmission [8,14].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of "anti-HBc alone" among Syrian blood donors

Muselmani

Habbal

Monem

2014

J Infect Dev Ctries

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Introduction: We aimed to evaluate the prevalence of "anti-HBc alone" among Syrian blood donors, highlighting the possibility of representing occult HBV infection. Methodology: Sera of 3,896 healthy blood donors were tested for both HBsAg and anti-HBc. HBsAg-negative, anti-HBc-positive samples were further tested for the antibodies to HBsAg (anti-HBs), and "anti-HBc alone" sera were tested for HBV DNA. Results: Of 3,830 HBsAg-negative donors, 63 were "anti-HBc alone" donors, five of whom were HBV DNA positive. Conclusions: Greater consideration should be given to the "anti-HBc alone" serological profile in blood screening, premarital testing, organ transplantation tests, and other HBV transmission-related procedures in Syria.

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“…A more recent study among Egyptian healthy male HBsAgnegative donors showed that 80/1026 (7.8%) were reactive to anti-HBc. Of those, 5 (6.25%) had HBV-DNA as detected by real-time polymerase chain [27] . It was shown that low levels of viremia are detectable in 1.6% to 38% of HBsAg-negative/anti-HBcpositive donors when highly sensitive techniques for the detection of HBV-DNA were used [28][29][30] .…”

mentioning

confidence: 99%

Occult hepatitis B virus infection among Egyptian blood donors

Said

Sayed²,

Salama

et al. 2013

WJH

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AIM:To identify blood donors with occult hepatitis B virus (HBV) infection (OBI) to promote safe blood donation. METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen (HBsAg), hepatitis C antibody (HCV Ab) and human immunodeficiency virus Ab. They were subjected to the detection of alanine aminotransferase (ALT) and aspartate transaminase (AST) and screening for anti-HBV core antibodies (total) by two different techniques; [Monoliza antibodies to hepatitis B core (Anti-HBc) Plus-Bio-Rad] and (ARC-HBc total-ABBOT). Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface (anti-HBs) (ETI-AB-AUK-3, Dia Sorin-Italy). Serum anti-HBs titers > 10 IU/L was considered positive. Quantitative HBV DNA by real time polymerase chain reaction (PCR) (QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L. Also, 265 recipients were included, 34 of whom were followed up for 3-6 mo. Recipients were investigated for ALT and AST, HBV serological markers: HBsAg (ETI-MAK-4, Dia Sorin-Italy), anti-HBc, quantitative detection of anti-HBs and HBV-DNA. RESULTS: 525/3167 (16.6%) of blood units were positive for total anti-HBc, 64% of those were antiHBs positive. Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples, where 451 (90.6%) confirmed positive. Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample, giving an overall prevalence of 451/3167 (14.2%) for total anti-HBc. HBV DNA was quantified by real time PCR in 52/303 (17.2%) of anti-HBc positive blood donors (viral load range: 5 to 3.5 x 10 5

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Significance of detecting anti-HBc among Egyptian male blood donors negative for HBsAg*

Abstract: This study shows the insufficient effectiveness of HBsAg screening in protecting blood recipients from HBV infection. Inclusion of anti-HBc testing should be considered in the screening of blood donors.

Cited by 39 publications

References 22 publications

Occult hepatitis B infection in Egyptian health care workers

Occult hepatitis B infection in Egyptian health care workers

Prevalence of "anti-HBc alone" among Syrian blood donors

Occult hepatitis B virus infection among Egyptian blood donors

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