Significance of Cytoplasmic Inclusions in Lupus Nephritis

Venkataseshan, V S; Marquet, E; Grishman, Edith

doi:10.3109/01913129109021300

Cited by 17 publications

(13 citation statements)

References 14 publications

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“…These findings were more suggestive of glomerular lesions in TA than of class II lupus nephritis. Furthermore, tubuloreticular bodies, which are a hallmark of lupus nephritis, were not found within the cytoplasm of endothelial cells on EM [6]. In particular, a similar bubble-like appearance in glomerular lesions has been reported in TA [1].…”

Section: Discussionmentioning

confidence: 96%

A case of lupus nephritis coexisting with podocytic infolding associated with Takayasu’s arteritis

2008

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A 61-year-old Japanese woman with both Takayasu's arteritis (TA) and systemic lupus erythematosus (SLE) presented with proteinuria due to glomerulopathy associated with podocytic infolding. She presented with unequal pulses in the upper extremities at 38 years old. TA was diagnosed on the basis of angiographic identification of stenosis in the left subclavian artery. Eight years after onset of TA, SLE was diagnosed on the basis of clinical and laboratory findings, including proteinuria, hematological and immunological abnormalities, high titer of antinuclear antibody, and a positive lupus band test on the skin. A renal biopsy showed lupus nephritis coexisting with podocytic infolding associated with TA, which has rarely been reported. After low-dose prednisolone therapy and immunosuppressive therapy by cyclosporine for 14 years, proteinuria has persisted without deterioration of serum creatinine levels.

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Section: Discussionmentioning

confidence: 96%

A case of lupus nephritis coexisting with podocytic infolding associated with Takayasu’s arteritis

2008

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“…TRIs were found in a high proportion of cases of active, untreated LN [25]. The presence or absence of TRIs has been proposed previously as a method to distinguish between idiopathic membranous glomerulonephritis and lupus class V nephropathy [26].…”

Section: Discussionmentioning

confidence: 97%

Accelerated recovery from nephrotic syndrome with acute renal failure by double filtration plasmapheresis in a patient with lupus podocytopathy

et al. 2012

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We describe a case of an adult female who presented with nephrotic syndrome. She was diagnosed with systemic lupus erythematosus with serum antinuclear antibodies, leucopenia with lymphopenia, butterfly erythema, and nephrotic syndrome. Renal biopsy revealed normal glomeruli with diffuse effacement of the foot processes, consistent with lupus podocytopathy. Although human albumin replacement was performed initially, acute renal failure developed rapidly. Therefore, she was treated with double filtration plasmapheresis (DFPP) in addition to oral steroid. After steroid therapy combined with DFPP, the renal function and proteinuria improved rapidly. Although the impact of DFPP on the treatment of lupus nephritis remains to be delineated, our observations suggest that DFPP in lupus podocytopathy played a pivotal role in facilitating the early recovery from renal injuries. Because of the rapid improvement of renal function without any change in body weight by DFPP, acute renal failure in the setting of lupus podocytopathy might contribute to an alternative pathophysiological factor for the diminished glomerular filtration rate, similar to that observed in the setting of idiopathic minimal change glomerulopathy.

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“…TRS are composed of a membranous network with interwoven tubules of approximately 22 In this study TRS were found in eight of 17 synovial fluids. They were predominantly in mononuclear cells with dense bodies and rough endoplasmic reticulum.…”

Section: Electron Microscopy Of Le Cellsmentioning

confidence: 97%

Synovial fluid cells in systemic lupus erythematosus: light and electron microscopic studies

Hr¹,

Hs²

1995

Lupus

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Joint fluid findings in systemic lupus erythematosus (SLE) have been described in only a few series and systematic electron microscopic study of the synovial fluid (SF) cells has not been reported. We describe the evaluation of 17 SF in patients with SLE with routine analysis and electron microscopy. Joint effusions had a wider range of leukocyte counts than often appreciated, with counts varying from 875 to 39,250 cells per mm3. LE inclusions were seen in eight fluids and have been shown to contain chromatin-like filaments by electron microscopy. There was little associated electron dense immunoglobulin-like material. Tubuloreticular structures (TRS) found in seven SF were mostly in mononuclear cells including some LE cells. The known association of TRS with alpha interferon and viral infections may have important implications for pathogenesis.

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Significance of Cytoplasmic Inclusions in Lupus Nephritis

Cited by 17 publications

References 14 publications

A case of lupus nephritis coexisting with podocytic infolding associated with Takayasu’s arteritis

A case of lupus nephritis coexisting with podocytic infolding associated with Takayasu’s arteritis

Accelerated recovery from nephrotic syndrome with acute renal failure by double filtration plasmapheresis in a patient with lupus podocytopathy

Synovial fluid cells in systemic lupus erythematosus: light and electron microscopic studies

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