Significance of Cytomegalovirus Prophylaxis Strategies and Development of Cancer in Kidney Transplant Recipients

Osorio, Juan C.; Medina, Romero; Patiño, Nasly; Ricaurte, Luisa; Moreno, Leandro Ferreira; Lozano, E.

doi:10.1016/j.transproceed.2011.09.090

Cited by 2 publications

(1 citation statement)

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“…Unlike other oncogenic viruses, the role of cytomegalovirus (CMV) in cancer development is less certain. A few observational studies have reported a higher incidence of cancer, particularly colorectal, lung, and skin cancers, among CMV‐exposed compared to CMV‐naïve KTR, while others did not find such an association . Given these conflicting findings in the existing literature, we sought to assess the association between CMV serological status of the recipient and the risk of cancer development after kidney transplantation using data from the Australia and New Zealand Dialysis and Transplant (ANZDATA) registry.…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus and cancer after kidney transplantation: Role of the human leukocyte antigen system?

Wong

Chakera

Chapman

et al. 2016

Transplant Infectious Dis

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Section: Introductionmentioning

confidence: 99%

Cytomegalovirus and cancer after kidney transplantation: Role of the human leukocyte antigen system?

Wong

Chakera

Chapman

et al. 2016

Transplant Infectious Dis

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Immune response to CMV in solid organ transplant recipients: current concepts and future directions

Watkins

Lemonovich

Razonable

2012

Expert Review of Clinical Immunology

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Despite advances in immunosuppression and antiviral therapy, CMV continues to be a significant opportunistic pathogen adversely affecting the outcome of solid organ transplantation (SOT) recipients. While a significant proportion of CMV disease is caused by reactivation of latent virus, the risk is highest among CMV donor+ and recipient- SOT patients. CMV is responsible for both direct (e.g., pneumonitis, colitis) and indirect (e.g., rejection, atherosclerosis) morbidity and mortality. Healthy CMV-seropositive individuals have a high frequency of CMV-specific CD4(+) and CD8(+) T cells that provide immune protection by limiting CMV reactivation and replication. Changes to the innate and adaptive immune system from immunosuppressive therapy following SOT contribute to CMV disease pathogenesis. CMV disease after SOT is associated with poorer outcomes, thus novel strategies to prevent it are an area of active research. In this article, we review the current state of knowledge on the immune response to CMV following SOT.

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Significance of Cytomegalovirus Prophylaxis Strategies and Development of Cancer in Kidney Transplant Recipients

Cited by 2 publications

References 16 publications

Cytomegalovirus and cancer after kidney transplantation: Role of the human leukocyte antigen system?

Cytomegalovirus and cancer after kidney transplantation: Role of the human leukocyte antigen system?

Immune response to CMV in solid organ transplant recipients: current concepts and future directions

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