Significance of chronic toxoplasmosis in epidemiology of road traffic accidents in Russian Federation

Stepanova, E. V.; Кондрашин, А В; Сергиев, В П; Morozova, Lola F.; Turbabina, Natalia A.; Maksimova, Maria S.; Brazhnikov, А. Yu.; Morozov, Evgeny N.

doi:10.1371/journal.pone.0184930

Cited by 15 publications

(4 citation statements)

References 17 publications

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“…In total, 11 studies comparing seropositivity to T. gondii with the risk of being involved in a TA were identified (Flegr et al ., 2002; Yereli et al ., 2006; Flegr et al ., 2009; Kocazeybek et al ., 2009; Galvan-Ramirez et al ., 2013; Samojlowicz et al ., 2013; Alvarado-Esquivel et al ., 2015; Shotar et al ., 2016; Sugden et al ., 2016; Stepanova et al ., 2017; Burgdorf et al ., 2019), showing an overall OR of 1.69 (95% CI 1.20–2.38, p = 0.003), see Fig. 2.…”

Section: Resultsmentioning

confidence: 99%

Driving us mad: the association of Toxoplasma gondii with suicide attempts and traffic accidents – a systematic review and meta-analysis

et al. 2019

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Unnatural causes of death due to traffic accidents (TA) and suicide attempts (SA) constitute a major burden on global health, which remained stable in the last decade despite widespread efforts of prevention. Recently, latent infection with Toxoplasma gondii (T. gondii) has been suggested to be a biological risk factor for both TA and SA. Therefore, a systematic search concerning the relationship of T. gondii infection with TA and/or SA according to PRISMA guidelines in Medline, Pubmed and PsychInfo was conducted collecting papers up to 11 February 2019 (PROSPERO #CRD42018090206). The random-effect model was applied and sensitivity analyses were subsequently performed. Lastly, the population attributable fraction (PAF) was calculated. We found a significant association for antibodies against T. gondii with TA [odds ratio (OR) = 1.69; 95% confidence interval (CI) 1.20–2.38, p = 0.003] and SA (OR = 1.39; 95% CI 1.10–1.76, p = 0006). Indication of publication bias was found for TA, but statistical adjustment for this bias did not change the OR. Heterogeneity between studies on SA was partly explained by type of control population used (ORhealthy controls = 1.9, p < 0.001 v. ORpsychiatric controls = 1.06, p = 0.87) and whether subjects with schizophrenia only were analysed (ORschizophrenia = 0.87, p = 0.62 v. ORvarious = 1.8, p < 0.001). The association was significantly stronger with higher antibody titres in TA and in studies that did not focus on schizophrenia subjects concerning SA. PAF of a T. gondii infection was 17% for TA and 10% for SA. This indicates that preventing T. gondii infection may play a role in the prevention of TA or SA, although uncertainty remains whether infection and outcome are truly causally related.

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Section: Resultsmentioning

confidence: 99%

Driving us mad: the association of Toxoplasma gondii with suicide attempts and traffic accidents – a systematic review and meta-analysis

et al. 2019

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“…Stepanova et al showed that due to the effect of toxoplasmosis, which caused a slower reaction time and reduced concentration in drivers, there was a statistically signi cant relationship between the rate of tra c accidents and the prevalence of toxoplasmosis. Hence, the prevalence of toxoplasmosis was 2.37 times higher in drivers who participated in road accidents than in control groups (21).…”

Section: Discussionmentioning

confidence: 81%

Higher risk of car accidents in older patients with Toxoplasma Gondii in Yazd province, center of Iran: A Cohort Study

Ghasemirad

Aalazade

Shariatpanahi

et al. 2022

Preprint

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Background Toxoplasmosis seems to be not only an infectious disease with known signs and symptoms, but it can also disturb the social behavioral aspects of animals and human. These social problems, especially memory disfunction, may lead to dangerous events like traffic accidents. The purpose of the study is to investigate and compare the rate of traffic accidents in people with positive serology for Toxoplasma gondiiand people with negative serology. Materials and Methods This is a retrospective cohort study conducted according to the statistics available in the laboratories of Yazd province, in the center of Iran, from 2018 to 2021. We used information of 360 people with driving licenses divided into two groups related to the data of the results of IgG test against Toxoplasma gondii, collected in the laboratories of Yazd, Iran. One group was seropositive and the other one was seronegative for Toxoplasma gondii. The statistical analysis of the traffic accidents during 2018-2021 were recorded by the traffic police system. Results The age of toxoplasmosis group was slightly more than control group. (36.2 and 34.08, respectively; p-value= 0.03). There was no significant difference between time of driving in toxoplasmosis and control group. (P-value= 0.06). The rate of accidents was higher in toxoplasmosis group. (36.7% and 20.6%; p-value<0.001). This rate was significantly higher in people of 35-69 years old compared with younger ones. (40% and 32.9% respectively; p-value=0.01) Conclusion People with latent toxoplasmosis had a significantly higher risk of car accidents than seronegative ones and this risk was higher in older people. Due to contradictory results about the effect of toxoplasmosis on traffic accidents and higher rate of toxoplasmosis in Persian cats, these findings should be taken into consideration in designing strategies for public health.

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“…Bei weltweit mehr als zwei Milliarden infizierten Menschen und einer hohen Variabilität der Infektionsraten (von 8,6% in Norwegen bis 60,4% in Brasilien; ▶Tab. 1) können jedoch auch kleine Effekte eine große Wirkung haben: Eine Häufung von Verkehrsunfällen (13,30) und Suizidversuchen sowie Suiziden (2, 6) nach abgelaufener Toxoplasmose-Infektion ist tatsächlich zu verzeichnen und lässt auf vermehrte Aggressivität, Impulsivität und risikoreicheres Verhalten schließen. Da die Durchseuchung der Bevölkerung in Deutschland etwa 50% beträgt, geht das uns alle durchaus an: Eine abgelaufene Infektion mit Toxoplasma gondii ist nicht völlig ohne Folgen.…”

Section: Spitzer Ulmunclassified

Parasitärer Kapitalismus

Spitzer¹

2018

Nervenheilkunde

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Significance of chronic toxoplasmosis in epidemiology of road traffic accidents in Russian Federation

Cited by 15 publications

References 17 publications

Driving us mad: the association of Toxoplasma gondii with suicide attempts and traffic accidents – a systematic review and meta-analysis

Driving us mad: the association of Toxoplasma gondii with suicide attempts and traffic accidents – a systematic review and meta-analysis

Higher risk of car accidents in older patients with Toxoplasma Gondii in Yazd province, center of Iran: A Cohort Study

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