Significance of changes in inflammatory parameters following uterine artery embolization in pre‑menopausal females

Abstract

The purpose of the present study was to describe the course of changes in laboratory inflammatory markers following bilateral uterine artery embolization (UAE) as a treatment for leiomyomas and adenomyosis. The body temperature was measured and blood samples were collected to determine white blood cell (WBC) count and C-reactive protein (CRP) levels in 270 patients on the day prior to UAE and for up to 4 days post-embolization. Aside from a single case with a non-inflammatory complication, none of the other cases had any complications. Post-UAE leukocytosis with a mean maximum value of 10.8±3.5x10 9 /l (range, 5.9-18.6x10 9 /l) was observed one-year post-intervention. The mean leukocyte numbers were indicated to be higher on day 3 post-UAE. The CRP level was also increased post-UAE, with a mean maximum value of 7.75±3.5 mg/dl. Maximum levels were reached in 8 patients on the 2nd and in 11 patients on the 3rd post-operative day. The maximum pain score was ~5.5 and reached its lowest level at the end of the 12th week post-intervention. The present study did not consider an association between the embolic material used or uterus size with the level of treatment success. No complications were observed post-UAE; however, a significant increase in the WBC count was observed within the first 3 days, indicating mild leukocytosis.

Retrospective Analysis of the Effect of Lidocaine Combined with Methylprednisolone on Pain Control After Uterine Artery Embolization

“…PES is caused by avascular necrosis of the muscle layer after UAE, which induces the release of cytokines and causes systemic inflammation ( 21 ). Previous studies have shown that glucocorticoids can reduce pain, nausea, and vomiting ( 22 ).…”

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

“…Relatively old data reveal that serum CRP titers can be more than 3 mg/L in women with endometriosis and uterine fibroids, and other data indicate that it is a marker of clinical importance in determining possible reproductive failure, whereas a more recent study showed that following bilateral Uterine Artery Embolization (UAE) as a treatment for leiomyomas and adenomyosis, CRP concentrations can be increased (a median of approx. 80 mg/L) [ 395 , 396 , 397 ]. In addition, other data show CRP levels above the cutoff level of 0.71 mg/L were independently linked to former Cervical Artery Dissection (CAD) regardless of conventional risk factors [ 398 ].…”

The Contribution of Uterine Artery Embolization as a Safe Treatment Option for Uterine Fibroids

“…In Table 1 are summarized the complications in our participants and according to international literature with the maximally respectively referred complications rate. The first column of the table refers to our results in the time from 2008 to 2020 while in the second column are shown the respective values of the examinated parameters in average concerning to international literature [72][73][74][75][76].…”