Significance of cadmium concentrations in blood and hair as an indicator of dose 15 years after the reduction of environmental exposure to cadmium

Liu, Xiao Jie; Arisawa, Kokichi; Nakano, Atsuhiro; Saitô, Hiroshi; Takahashi, Tatsuya; Kosaka, A.

doi:10.1016/s0378-4274(01)00381-2

Cited by 12 publications

(5 citation statements)

References 10 publications

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“…A similar study was also conducted by Gowda et al (2003) showed comparatively higher Cd (0.065 ppm) levels in the blood plasma of dairy animals. Based on our data, elevation of serum Cd could be due to high concentration of Cd in water so blood concentration of Cd acts as an indicator for reflecting their environmental existence, this is in conformity with (Liu et al, 2001).…”

Section: Discussionsupporting

confidence: 75%

Assessing of Heavy Metals in Serum of Barki Sheep in Rainfed Area at Matrouh Governorate

Morsy¹,

El-Ghannam

Saleh

et al. 2020

Journal of Veterinary Medical Research

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The present study was conducted to determine serum concentrations of lead (Pb), cadmium (Cd), copper (Cu), zinc (Zn), iron (Fe), and selenium (Se) of Barki sheep reared in the rainfed area at Matrouh Governorate, Egypt. Forty apparently healthy Barki sheep (2-4 years of age) were randomly selected from Marsa Matrouh and El Negaila farms (twenty each) for this study. In addition to twenty healthy Barki sheep aged 2-4 years, obtained from Borg El Arab farm, represented as control. Animals classified into 3 groups according to water source: Borg El Arab as control (Tap water); Matrouh (Rainfall water); El Negaila (Rainfall Water). Water and serum samples were prepared for the detection and estimation of selected metals by using Flame Atomic Absorption Spectrometer. Metal analysis revealed that Pb levels in different water samples were recorded above the EWQS of 0.01 ppm in following: El Negaila > Matrouh > control, Cd levels were recorded in El Negaila (RW) and Matrouh (RW) above recommended limit of 0.003, Se levels were recorded above maximum limit EWQS of 0.01 ppm in control (TW) followed by El Negaila and Matrouh however the levels of Cu, Zn, and Fe from the surveyed areas were below EWQS limits. Serum mineral analysis, Pb level was significantly increased only in examined sheep of El Negaila, Cd levels were higher in examined sheep of El Negaila and Matrouh however, Cu, Zn, and Fe levels were significantly lower compared to the control group. Conclusion: water analysis showed that Cu, Zn, and Fe concentrations were within the levels recommended by EWQS except for Pb, Cd and Se levels which need more attention. Serum analysis revealed high levels of Pb, Cd, and Se however deficient to marginal levels of Zn and Cu were detected in examined sheep. These results should provide a database for the mineral status of Barki sheep and their drinking water quality in Matrouh and El Negaila as well as evaluate environmental pollution status in this area.

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Section: Discussionsupporting

confidence: 75%

Assessing of Heavy Metals in Serum of Barki Sheep in Rainfed Area at Matrouh Governorate

Morsy¹,

El-Ghannam

Saleh

et al. 2020

Journal of Veterinary Medical Research

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“…Thus, Nordberg and Nishiyama (1972) have reported a strong positive correlation between hair-Cd and body burden in mice whereas Ellis et al (1981) did not consider hair-Cd to be a good indicator of body burden. Liu et al (2001) have found that the correlation between hair-Cd and body burden is weak or moderate by comparing Cd in hair, blood and urine; they observed a stronger association between hair-Cd and urine-Cd than between hair-Cd and blood-Cd. Fatty foods (e.g.…”

Section: Hairmentioning

confidence: 99%

Non-invasive matrices in human biomonitoring: A review

Esteban

Castaño

2009

Environment International

442

192

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“…This indicates that both B-Cd and U-Cd are valid as indicators of long-term environmental exposure of the general population to cadmium. Several studies have supported this assumption and the close correlation between B-Cd and U-Cd in such circumstances (Liu et al 2001;Moon et al 1999;Roels et al 1993). In fact, many years after an exposure, B-Cd is likely better than U-Cd as an indicator of previous exposure because if tubular damage has occurred, U-Cd measurements may be difficult to interpret (Börjesson et al 2001;Ikeda et al 1999;Järup et al 2000).…”

Section: Case Discussionmentioning

confidence: 85%

Cadmium exposure and nephropathy in a 28-year-old female metals worker.

Wittman¹,

Hu²

2002

Environ Health Perspect

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A 28-year-old female presented for evaluation of left flank pain and polyuria after having been exposed to cadmium in the jewelry manufacturing industry for approximately 3 years. This patient possessed both elevated 24-hr urinary β 2 -microglobulin and elevated blood cadmium levels. Approximately 6 months after initial presentation, the patient resigned from her job due to shortness of breath, chest pain, and anxiety. Exposure to cadmium in the jewelry industry is a significant source of occupational cadmium exposure. Other occupational sources include the manufacture of nickel-cadmium batteries, metal plating, zinc and lead refining, smelting of cadmium and lead, and production of plastics. Cadmium is also an environmental pollutant that accumulates in leafy vegetables and plants, including tobacco. Major toxicities anticipated from cadmium exposure involve the renal, pulmonary, and, to a lesser extent, gastrointestinal systems. These include the development of renal proximal tubular dysfunction, glomerular damage with progressive renal disease, and respiratory symptoms including pneumonitis and emphysema. Low-level cadmium exposure has also been associated with increased urinary calcium excretion and direct bone toxicity, effects that recent research suggests may result in the development of osteoporosis. The body burden of cadmium, over half of which may reside in the kidneys, is most often measured through the use of urinary cadmium levels. Blood cadmium measurements generally reflect current or recent exposure and are especially useful in cases with a short exposure period and only minimal accumulation of cadmium in the kidneys. Both β 2 -microglobulin and α 1 -microglobulin serve as organ-specific, early-effect biomarkers of tubular proteinuria and thus play a role in identifying early signs of cadmium-induced renal damage in those with potential exposures. In addition to ensuring workplace compliance with Occupational Safety and Health Administration-mandated monitoring and screening measures, it is prudent for those with cadmium exposure to maintain adequate intake of both iron and calcium, appropriate measures even in the absence of exposure.

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Significance of cadmium concentrations in blood and hair as an indicator of dose 15 years after the reduction of environmental exposure to cadmium

Cited by 12 publications

References 10 publications

Assessing of Heavy Metals in Serum of Barki Sheep in Rainfed Area at Matrouh Governorate

Assessing of Heavy Metals in Serum of Barki Sheep in Rainfed Area at Matrouh Governorate

Non-invasive matrices in human biomonitoring: A review

Cadmium exposure and nephropathy in a 28-year-old female metals worker.

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