Significance of Blood Eosinophil Count in  Patients with Chronic Rhinosinusitis with  Nasal Polyposis

Sreeparvathi, Ammu; Kalyanikuttyamma, Lathi Kumari; Kumar, Madhumita; Sreekumar, Nandagopan; Narendrakumar, Veerasigamani

doi:10.7860/jcdr/2017/25320.9445

Cited by 29 publications

(25 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chen et al 48 found that peripheral eosinophils were a risk factor for NP ( 50 . Furthermore, eosinophilia was also associated with worse respiratory function 37,[51][52][53][54][55][56][57] , disease severity 32,51,[58][59][60][61] , and greater CRSwNP recurrence rates 49,62,63 . Guo et al 62 reported that blood eosinophil counts of 0.25 Â 10 3 /mL (OR 3.63; 95% CI 0.73-18.10) or 2.6% blood eosinophils (OR 5.12; 95% CI 0.62-42.58) predicted multiple recurrences of CRSwNP after FESS.…”

Section: Risk Factorsmentioning

confidence: 94%

“…Facial pain, nasal congestion, loss of smell, sneezing, and headache were the most commonly reported symptoms for patients with CRSwNP. Facial pain was reported for 60-92.2% of patients in North America 16,27 , 31-45% of patients in Europe 28,29 , and 19-100% of patients in Asia [30][31][32][33] . Nasal congestion was reported in 95-100% of patients with CRSwNP in North America 17,27 , 73-88% of patients in Europe 34,35 , and 76-81% of patients in Asia 31,36 .…”

Section: Symptomsmentioning

confidence: 99%

“…Nasal congestion was reported in 95-100% of patients with CRSwNP in North America 17,27 , 73-88% of patients in Europe 34,35 , and 76-81% of patients in Asia 31,36 . Loss of smell was reported for 56-84% of patients with CRSwNP in North America 16,27 , 35-90% of patients in Europe 28,34,35,37,38 , and 30-100% of patients in Asia [30][31][32]36,39 . Sneezing was reported for 88% of patients in North America 26 , 12-73% of patients in Europe 28,34,35,38 , and 27-51% of patients in Asia 31,33 .…”

Section: Symptomsmentioning

confidence: 99%

See 2 more Smart Citations

Systematic literature review of the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyposis

Chen

Zhou

Emmanuel

et al. 2020

Current Medical Research and Opinion

View full text Add to dashboard Cite

Objectives: We conducted a systematic literature review (SLR) to determine the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyps (CRSwNP) and to describe how the addition of biologics has affected outcomes for patients with CRSwNP. Methods: The SLR adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Embase, MEDLINE, and Evidence-Based Medicine Reviews databases were searched using OVID. Relevant studies published between 1

show abstract

Section: Risk Factorsmentioning

confidence: 94%

Section: Symptomsmentioning

confidence: 99%

Section: Symptomsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic literature review of the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyposis

Chen

Zhou

Emmanuel

et al. 2020

Current Medical Research and Opinion

View full text Add to dashboard Cite

show abstract

“…A remarkable association between high peripheral EOS levels and the morbidity of CRSwNP was identified. In several previous studies, eosinophilic inﬂammation of the nasal mucosa has been shown to play a role in nasal polyp pathogenesis and it has a negative impact on the prognosis and is associated with worse treatment outcomes [15, 19, 25-27]. Also eosinophilic inflammation has been reported to be related to disease severity.…”

Section: Discussionmentioning

confidence: 99%

Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China

Chen

Qiao

et al. 2019

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Nasal polyps are a common health problem that can significantly impact the quality of life. Objective: To analyze the impact of allergy and peripheral eosinophils (EOS) on the morbidity of chronic rhinosinusitis with nasal polyps (CRSwNP) in Northwest China. Methods: A retrospective cohort of 323 patients who underwent endoscopic sinus surgery (ESS) for chronic rhinosinusitis without nasal polyps (CRSsNP) and CRSwNP in Xijing Hospital was studied between January 5, 2011, and January 4, 2015. All of the patients underwent an allergen skin prick test and peripheral blood EOS inspection. Detailed information regarding the impact of allergy and EOS on the morbidity of CRSwNP was collected. Potential risk factors associated with nasal polyps were explored using logistic regression analysis. Multivariate logistic regression was performed to identify independent risk factors. Results: The results revealed that EOS is an important risk factor for nasal polyps. In the univariate analysis, the adjusted OR was 2.01 (95% CI 1.08–3.72; p = 0.027). In the multivariate analysis, the adjusted OR was 2.02 (95% CI 1.08–3.76; p = 0.027). Compared to allergic rhinitis and normal EOS levels, nonallergic rhinitis and elevated EOS levels constituted a risk factor for CRSwNP (OR = 2.70; 95% CI 1.32–5.50). Compared to allergen-positive and EOS-normal status, allergen-negative and elevated-EOS status constituted a risk factor for CRSwNP (OR = 2.95; 95% CI 1.38–6.33). Conclusion: EOS is a significant factor related to the morbidity of CRSwNP in Northwest China. Elevated EOS levels occurring in the context of nonallergic rhinitis constitute a risk factor for CRSwNP. Similarly, elevated EOS levels occurring in the context of allergen-negative rhinitis are also an important risk factor for morbidity of CRSwNP.

show abstract

“…Studies have shown that blood eosinophilia correlates with high tissue eosinophilia in CRS (5) and patients with both high blood IgE and eosinophils have a more aggressive disease phenotype resistant to treatment (6,7) . Furthermore, individuals who have CRSwNP have been shown to have elevated tissue IgE and eosinophils (8) .…”

Section: Introductionmentioning

confidence: 99%

Chronic rhinosinusitis and omalizumab: eosinophils not IgE predict treatment response in real-life

Sahota¹,

Bidder²,

Robinson³

et al. 2018

RHINOL

View full text Add to dashboard Cite

Background: Chronic rhinosinusitis with and without nasal polyps (CRSwNP and CRSsNP respectively) can be difficult to treat and biologics offer potential as a future therapeutic intervention. CRS and severe asthma often co-exist. Omalizumab is currently licenced for the treatment of severe allergic asthma. Objective: The aim was to determine which blood biomarkers and treatment variables were associated with clinical response for sinonasal symptoms in patients with allergic CRSsNP and CRSwNP who were treated with omalizumab for severe allergic asthma. Methods: Sinonasal outcome test (SNOT)-22 scores were recorded in a cohort of patients with allergic CRSsNP (n=10) or CRSwNP (n=15) treated with omalizumab for severe asthma according to UK guidelines. Using a linear modelling approach, the improvement in the SNOT-22 score as the treatment variable against several disease and treatment predictor variables was modelled. Results: SNOT-22 significantly decreased with omalizumab treatment. Increased blood eosinophil count and omalizumab dosing every two weeks (as opposed to every 4 weeks) were associated with greater reductions in SNOT-22 after 16 weeks of omalizumab treatment. Conclusion: Our study confirms that omalizumab is an effective treatment for CRS, and suggests that improvements are greater in those with eosinophilic disease. Further studies are required to determine long term efficacy and whether this treatment could reduce the need for surgery.

show abstract

Significance of Blood Eosinophil Count in Patients with Chronic Rhinosinusitis with Nasal Polyposis

Cited by 29 publications

References 17 publications

Systematic literature review of the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyposis

Systematic literature review of the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyposis

Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China

Chronic rhinosinusitis and omalizumab: eosinophils not IgE predict treatment response in real-life

Contact Info

Product

Resources

About