Significance of baseline FDG-PET/CT scan as a method of staging regional lymph nodes in patients with operable distal oesophageal or gastroesophageal junction adenocarcinoma

Papaxoinis, George; Weaver, Jamie; Khoja, Leila; Patrão, Ana Sofia; Stamatopoulou, Sofia; Alchawaf, Alia; Owen-Holt, Vikki; Germetaki, Theodora; Kordatou, Zoe; Mansoor, Wasat

doi:10.1080/0284186x.2017.1328127

Cited by 1 publication

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“…Adenocarcinoma is more common in Western countries like United States, Western and Northern Europe, whereas ESCC is more frequent seen in regions so-called “Asian esophageal cancer belt” that encompasses areas such as Iran, Kazakhstan and northern and central China [1]. Incidence of ESCC in our location (Henan province, Central China) is high and remains difficult to cure [2], primarily because of its extremely aggressive nature and frequent regional lymph node metastasis even at initial diagnosis [2, 3]. Due to this fact, much research have recently focused on mechanisms involving in ESCC tumor invasion and progression [4–7].…”

Section: Introductionmentioning

confidence: 99%

Cellular and clinicopathological features of the IL-33/ST2 axis in human esophageal squamous cell carcinomas

Cui

Ren

et al. 2018

Cancer Cell Int

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BackgroundEmerging evidence has suggested that interleukin (IL)-33 and its primary functional receptor ST2 are involved in the pathogenesis of tumorigenesis.MethodsUsing immunohistochemistry (IHC) and double immunofluorescence staining, we characterized the cellular and clinicopathological features of the IL-33/ST2 axis in different compartments in human esophageal squamous cell carcinoma (ESCC) surgical specimens.ResultsIHC data revealed an increased expression of IL-33-immunoreactivity (IR) and ST2-IR located in both ESCC cells and tumor stromal cells; which were associated with advanced clinicopathological features such as TNM stages and node involvement. However, the Kaplan–Meier analysis showed that densities of neither IL-33 positive nor ST2 positive cells in both the ESCC mass and stroma were associated with the overall survival rate in patients with ESCC. Double immunofluorescence staining for cellular feature analysis demonstrated that these IL-33 positive and ST2 positive cells in ESCCs were with a high proliferation rate, and IL-33-IR was frequently co-expressed with ST2-IR in both ESCC and stromal cells.ConclusionSignificant altered cellular features of the IL-33/ST2 axis in ESCCs were associated with advanced clinicopathological variables. The data suggest that the IL-33/ST2 axis might be involved in the progression of human ESCCs.

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Section: Introductionmentioning

confidence: 99%

Cellular and clinicopathological features of the IL-33/ST2 axis in human esophageal squamous cell carcinomas

Cui

Ren

et al. 2018

Cancer Cell Int

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show abstract

Significance of baseline FDG-PET/CT scan as a method of staging regional lymph nodes in patients with operable distal oesophageal or gastroesophageal junction adenocarcinoma

Abstract: We propose that the incorporation of RLN status (by FDG PET/CT scan) into the AJCC8 staging system of O/GOJ adenocarcinoma improves its prognostic accuracy and may also improve treatment stratification.

Cited by 1 publication

References 29 publications

Cellular and clinicopathological features of the IL-33/ST2 axis in human esophageal squamous cell carcinomas

Cellular and clinicopathological features of the IL-33/ST2 axis in human esophageal squamous cell carcinomas

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