2019
DOI: 10.1097/cnd.0000000000000269
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Significance of Asymptomatic Hyper Creatine-Kinase Emia

Abstract: Objectives: Whether asymptomatic hyper-CKemia (AHCE) should prompt a thorough work-up for muscle disease or not is controversially discussed. This review aims at summarizing and discussing recent findings concerning the cause, frequency, evolution, and work-up of conditions manifesting as AHCE and normal or abnormal electromyography (EMG) respectively muscle biopsy. Methods: Systematic PubMed search. Results: … Show more

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Cited by 5 publications
(3 citation statements)
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“…Elevations may be multifactorial, caused by an interaction between patient demographic factors, concomitant pathology, and/or drug therapies such as statins. Finally, a small percentage of people with creatine kinase elevations are ultimately found to have a hereditary myopathy 910. By contrast, central nervous system disorders such as parkinsonism, myasthenia gravis, or multiple sclerosis do not usually cause elevations of creatine kinase unless complicated by inflammatory myositis 11.…”
Section: What Can Cause An Elevated Creatine Kinase?mentioning
confidence: 99%
“…Elevations may be multifactorial, caused by an interaction between patient demographic factors, concomitant pathology, and/or drug therapies such as statins. Finally, a small percentage of people with creatine kinase elevations are ultimately found to have a hereditary myopathy 910. By contrast, central nervous system disorders such as parkinsonism, myasthenia gravis, or multiple sclerosis do not usually cause elevations of creatine kinase unless complicated by inflammatory myositis 11.…”
Section: What Can Cause An Elevated Creatine Kinase?mentioning
confidence: 99%
“…На доклинической стадии, когда нет слабости аксиальной мускулатуры, мышц конечностей, скелетных мышц и дыхательных нарушений, БППН может проявляться изолированным повышением креатинкиназы (не выше 2000 Ед / л) [54][55][56]. Однако среди пациентов с бессимптомной гиперкреатинкиназемией число выявленных лиц с БППН, по данным литературы, не превышает 4 % [57,58].…”
Section: лекции и обзорыunclassified
“…1 Isolated and asymptomatic elevation of creatine-kinase (hyper-CKemia) can be one of these initial manifestations. 2 Here, we present an asymptomatic patient with MID who initially manifested with isolated hyper-CKemia and respiratory chain dysfunction as indicators of a chemical and biochemical myopathy.…”
Section: Introductionmentioning
confidence: 98%