Significance of anti-phospholipid antibodies in patients with lupus nephritis

Frampton, Geoffrey; Hicks, Jackie; Cameron, J S

doi:10.1038/ki.1991.155

Cited by 78 publications

(51 citation statements)

References 16 publications

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“…The prevalence of aPL antibody was similar to that reported in many other studies of patients with SLE (19), it was also apparently similar to that reported from previous studies of patients with lupus nephritis (7,8,12,20). Forty-one percent of our patients developed vascular thrombosis, similar to that reported recently for a lupus nephritis series (21).…”

Section: Discussionsupporting

confidence: 79%

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Antiphospholipid Antibodies and Renal Outcomes in Patients with Lupus Nephritis

et al. 2009

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Section: Discussionsupporting

confidence: 79%

“…antibodies on the outcomes of lupus nephritis are conflicting, mainly because they are based on studies with short follow-up periods (8)(9)(10)(11)(12).…”

Section: Antiphospholipid Syndrome (Aps) Is a Disorder Characterized mentioning

confidence: 99%

Antiphospholipid Antibodies and Renal Outcomes in Patients with Lupus Nephritis

et al. 2009

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“…34 35 Loizou et al found that raised levels of aCL were associated with LN but were unable to show an association with anti-β 2 -glycoprotein I and did not look for the presence of LA. Moreover, they found that the presence of aCL in conjunction with raised levels of anti-dsDNA and anti-C1q antibodies is highly specific for LN.…”

Section: Discussionmentioning

confidence: 99%

Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis

Alba¹,

Bento²,

Cuadrado³

et al. 2003

Annals of the Rheumatic Diseases

187

136

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Background: Lupus nephritis (LN) is a common manifestation in patients with systemic lupus erythematosus (SLE). Autoantibodies and ethnicity have been associated with LN, but the results are controversial. Objective: To study the immunological and demographic factors associated with the development of LN. Patients and methods: A retrospective case-control study of 127 patients with biopsy-proven LN, and 206 randomly selected patients with SLE without nephritis as controls was designed. All patients had attended our lupus unit during the past 12 years. Standard methods were used for laboratory testing. Results: Patients with LN were significantly younger than the controls at the time of SLE diagnosis (mean (SD) 25.6 (8.8) years v 33.7 (12.5) years; p<0.0001). The proportion of patients of black ethnic origin was significantly higher in the group with nephritis (p=0.02). There were no differences in sex distribution or duration of follow up. A higher proportion of anti-dsDNA, anti-RNP, anti-Sm, and lupus anticoagulant (LA) was seen in the group with nephritis (p=0.002; p=0.005; p=0.0001; p=0.01, respectively). In univariate, but not in multivariate, analysis male sex and absence of anti-dsDNA were associated with earlier onset of renal disease (p=0.03; p=0.008). In multivariate analysis the only factors associated with nephritis were younger age at diagnosis of SLE, black race, presence of anti-dsDNA, anti-Sm, and LA. No demographic or immunological associations were seen with WHO histological classes. Conclusions: Young, black patients with anti-dsDNA, anti-Sm antibodies, and positive LA, appear to have a higher risk of renal involvement. These patients should be carefully monitored for the development of LN.

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“…Several authors investigated the role of the antiphospholipid antibodies in systemic lupus erythematosus (SLE) patients with renal involvement [22][23][24][25]. Farrugia et al [22] compared LACnegative SLE patients with renal dysfunction to SLE patients with renal impairment and detectable LAC.…”

Section: Discussionmentioning

confidence: 99%

Massive Proteinuria as a Main Manifestation of Primary Antiphospholipid Syndrome

Levy¹,

George²,

Ziporen³

et al. 1998

Pathobiology

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Renal involvement in antiphospholipid syndrome (APS) is increasingly reported. So far, massive proteinuria as the principal feature of primary APS (PAPS) has not been well documented. We describe 3 patients with PAPS and massiv proteinuria. Renal biopsy was performed in all 3, and features consistent with membranous and focal segmental glomerulopathy were disclosed. These histological lesions were not yet reported in PAPS. We conclude that the spectrum of renal lesions in PAPS is diverse and that it should be considered in the differential diagnosis of patients with massive proteinuria.

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Significance of anti-phospholipid antibodies in patients with lupus nephritis

Cited by 78 publications

References 16 publications

Antiphospholipid Antibodies and Renal Outcomes in Patients with Lupus Nephritis

Antiphospholipid Antibodies and Renal Outcomes in Patients with Lupus Nephritis

Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis

Massive Proteinuria as a Main Manifestation of Primary Antiphospholipid Syndrome

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