Significance of Acanthosis Nigricans

Curth, Helen Ollendorff

doi:10.1001/archderm.1952.01530260083009

Cited by 83 publications

(17 citation statements)

References 14 publications

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“…[4][5][6][7][8] Furthermore, there are reports of benign, generalized AN in early childhood without a positive family history, malignancy, associated syndrome, causative medication, or comorbid condition. [9][10][11][12][13][14][15] Only a few families with isolated (nonsyndromic, noninsulin resistance-associated) familial AN have been reported in the literature. [4][5][6][7][8] Inheritance tends to be autosomal dominant with variable penetrance.…”

Section: 3mentioning

confidence: 99%

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Familial Acanthosis Nigricans Due to K650T FGFR3 Mutation

Berk

Spector²,

Bayliss³

2007

Arch Dermatol

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Section: 3mentioning

confidence: 99%

“…In addition, 2 cases of benign AN (no family history) in early childhood have been associated with pyramidal tract degeneration. 11,15 Familial AN may be confused with ichthyosis hystrix, 5 generalized epidermal nevi, or lichenification in atopic dermatitis.…”

Section: 3mentioning

confidence: 99%

Familial Acanthosis Nigricans Due to K650T FGFR3 Mutation

Berk

Spector²,

Bayliss³

2007

Arch Dermatol

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“…Although a significant number of cases have since been reported, it has been controversial whether CRP is a dis tinctive clinical entity or not [10]. Curth [11) reported a 14-ycar-old, very obese girl who had both AN on the axillae and nape and CRP-like skin changes on her sternal area. He regarded CRP as a variant of AN with obesity.…”

Section: Discussionmentioning

confidence: 99%

Confluent and Reticulated Papillomatosis: A Case with Concurrent Acanthosis nigricans Associated with Obesity and Insulin Resistance

1994

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A 19-year-old Japanese man with confluent and reticulated papillomatosis (CRP) is presented. He was an obese and dark-complexioned man, who had impaired glucose tolerance and hyperinsulinemia. The clinical and histological findings were consistent with the diagnosis of CRP. He also had acanthosis nigricans (AN) on his axillae and nape. Neither spores nor hyphae were detected from scales; antifungal treatment had no benefit. Although the reduction of his weight was unsuccessful, oral etretinate therapy resulted in considerable improvement of both CRP and AN. We reviewed previous case reports in terms of the relation between CRP and AN. Although the two conditions are usually differentiated because of their distinctive clinical features, a close relationship was noted between CRP and AN.

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“…nign AN, the pseudoacanthosis nigricans as sociated with obesity or hormonal distur bances and the AN as part of some syn dromes such as Bloom's or Crouzon's syn drome [Curth, 1952[Curth, , 1976 or AN with insu lin-resistant diabetes [Kahn et al, 1976].…”

Section: Introductionmentioning

confidence: 99%

Acanthosis nigricans maligna

Gross

Pfister²,

Hellenthal

et al. 1984

Dermatology

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2 cases of acanthosis nigricans associated with an adenocarcinoma (signet ring cell carcinoma) of the stomach and a metastasizing small-cell carcinoma of unknown origin are reported. In both cases the skin lesions preceded the diagnosis of the carcinoma by months and acanthosis nigricans maligna was suspected by onset and localization of the dermatosis. There was no evidence of a papillomavirus etiology of the warty skin lesions. Virus particles could not be demonstrated either in ultrathin sections or in buffer extracts. Virus-specific DNA was not detectable after CsCL-ethidium bromide gradient centrifugation and cellular DNA did not hybridize under stringent or relaxed conditions with ³²P-labelled human papillomavirus 6 or human papillomavirus 8 DNA.

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Significance of Acanthosis Nigricans

Cited by 83 publications

References 14 publications

Familial Acanthosis Nigricans Due to K650T FGFR3 Mutation

Familial Acanthosis Nigricans Due to K650T FGFR3 Mutation

Confluent and Reticulated Papillomatosis: A Case with Concurrent Acanthosis nigricans Associated with Obesity and Insulin Resistance

Acanthosis nigricans maligna

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