Significance and Utility of Plasma Brain Natriuretic Peptide Concentrations in Patients with Idiopathic Ventricular Arrhythmias

Tada, Hiroshi; Ito, Sachiko; Shinbo, Goro; Tadokoro, Kazuyoshi; Ito, Itaru; Hashimoto, Tohru; Miyaji, Kohei; Kaseno, Kenichi; Naito, Shigeto; Nogami, Akihiko; Taniguchi, Koichi

doi:10.1111/j.1540-8159.2006.00553.x

Cited by 24 publications

(30 citation statements)

References 33 publications

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“…Despite comparable EF values in both groups, the patients with enhanced arrhythmia showed greater left ventricular end-systolic (LVESD) and greater left ventricular end-diastolic (LVEDD) diameters. Hiroshi and Tada 24 have reported similar results. They found higher BNP levels in patients with ventricular tachycardia and premature ventricular contractions originating from the left rather than the right ventricle.…”

Section: Discussionsupporting

confidence: 72%

N‐terminal Prohormone Brain Natriuretic Peptide‐proBNP Levels in Ventricular Arrhythmias in Children

Mazurek

Szydłowski

Giec-Fuglewicz

et al. 2009

Clinical Cardiology

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Background Ventricular arrhythmias are the most common consequences of structural and functional heart diseases, but cases with no evident pathology are also observed. A parameter indicating asymptomatic circulatory failure could support decisions related to possible treatment of ventricular arrhythmias. Hypothesis The study objective was the evaluation of N‐terminal prohormone brain natriuretic peptide (NT‐proBNP) levels in children with ventricular arrhythmias and an attempt to determine if this parameter may be used for diagnosis and prognosis of ventricular arrhythmias. Material and methods The study population was comprised of 36 children age 5 to 17.5 years old with idiopathic ventricular arrhythmias (Group B) graded mild or potentially malignant; 29 patients with mild ventricular arrhythmias were included into Group B1; and 7 patients with potentially malignant cases into Group B2. In all the patients, NT‐proBNP assays were performed. Results The NT‐proBNP levels in Groups B, B1, B2 and the control group (Group K) were as follows: 41.5 ± 15.1 pg/mL, 35.5 ± 18.5 pg/mL, 66.3 ± 24.9 pg/mL and 31.5 ± 15.1 pg/mL, respectively. Between the groups with and without arrhythmias (Group B vs Group K), no statistically significant differences in NT‐proBNP levels were found. However, markedly higher NT‐proBNP levels were shown in the children with potentially malignant arrhythmias (Group B2) compared to the patients with mild arrhythmias (B1) and the control group (Group K). Conclusions The level of NT‐proBNP increases with the severity of ventricular arrhythmia. NT‐proBNP assays can be helpful for diagnosing and grading the severity of ventricular arrhythmias. Copyright © 2009 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 72%

N‐terminal Prohormone Brain Natriuretic Peptide‐proBNP Levels in Ventricular Arrhythmias in Children

Mazurek

Szydłowski

Giec-Fuglewicz

et al. 2009

Clinical Cardiology

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“…9,10 Previous studies suggest that BNP may serve as a sensitive marker to detect PVC-induced increased ventricular wall stress, with unclear clinical relevance in the presence of normal LV function. 7,8 Circumferential end-systolic wall stress (cESS) on echocardiography has also been proposed as a marker for ventricular wall stress. 11 Increased ventricular wall stress may be related to fatigue as presenting symptom and perhaps to PVC-induced cardiomyopathy.…”

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confidence: 99%

“…[7][8][9] The main stimulus for (NT-pro)BNP secretion is myocardial wall stress. 9,10 Previous studies suggest that BNP may serve as a sensitive marker to detect PVC-induced increased ventricular wall stress, with unclear clinical relevance in the presence of normal LV function.…”

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confidence: 99%

Fatigue as Presenting Symptom and a High Burden of Premature Ventricular Contractions Are Independently Associated With Increased Ventricular Wall Stress in Patients With Normal Left Ventricular Function

Taxis

Piers

Silva

et al. 2015

Circ: Arrhythmia and Electrophysiology

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Background-High idiopathic premature ventricular contractions (PVC) burden has been associated with PVC-induced cardiomyopathy. Patients may be symptomatic before left ventricular (LV) dysfunction develops. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and circumferential end-systolic wall stress (cESS) on echocardiography are markers for increased ventricular wall stress. This study aimed to evaluate the relation between presenting symptoms, PVC burden, and increased ventricular wall stress in patients with frequent PVCs and preserved LV function. Methods and Results-Eighty-three patients (41 men; 49±15 years) with idiopathic PVCs and normal LV function referred for PVC ablation were included. Type of symptoms (palpitations, fatigue, and [near-]syncope), PVC burden on 24-hour Holter, NT-proBNP levels, and cESS on echocardiography were assessed before and 3 months after ablation. Sustained successful ablation was defined as ≥80% PVC burden reduction during follow-up. Patients were symptomatic for 24 months (Q1-Q3, 16-60); 73% reported palpitations, 47% fatigue, and 30% (near-)syncope. Baseline PVC burden was 23±13%, median NT-proBNP 92 pg/mL (Q1-Q3 50-156), and cESS 143±35 kdyne/cm 2 . Fatigue was associated with higher baseline NT-proBNP and cESS (P<0.001, P=0.011, respectively). After sustained successful ablation, achieved in 81%, NT-proBNP and cESS decreased significantly (P<0.001 and P=0.036, respectively). Fatigue was independently associated with a significantly larger reduction in NT-proBNP. In patients with nonsuccessful ablation, NT-proBNP and cESS remained unchanged. Conclusions-In patients with frequent PVCs and preserved LV function, fatigue was associated with higher baseline NT-proBNP and cESS, and with a significantly larger reduction in NT-proBNP after sustained successful ablation. These findings support a link between fatigue and PVC-induced increased ventricular wall stress, despite preserved LV function.

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“…A conventional ehocardiographic examination was also performed before the ablation procedure, and the LV end-diastolic diameter, LV ejection fraction, and LV mass was measured in all patients. [16][17][18] Ethical approval was obtained from the hospital's ethics committee, and all patients gave written informed consent before participation.…”

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confidence: 99%

Gender and Age Differences in Candidates for Radiofrequency Catheter Ablation of Idiopathic Ventricular Arrhythmias

Tanaka

Tada

Ito

et al. 2011

Circ J

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Significance and Utility of Plasma Brain Natriuretic Peptide Concentrations in Patients with Idiopathic Ventricular Arrhythmias

Abstract: The plasma BNP concentration was elevated in about 60% of the patients with symptomatic I-VT/PVCs. Normalization of the high BNP concentration after ablation may indicate a successful ablation.

Cited by 24 publications

References 33 publications

N‐terminal Prohormone Brain Natriuretic Peptide‐proBNP Levels in Ventricular Arrhythmias in Children

N‐terminal Prohormone Brain Natriuretic Peptide‐proBNP Levels in Ventricular Arrhythmias in Children

Fatigue as Presenting Symptom and a High Burden of Premature Ventricular Contractions Are Independently Associated With Increased Ventricular Wall Stress in Patients With Normal Left Ventricular Function

Gender and Age Differences in Candidates for Radiofrequency Catheter Ablation of Idiopathic Ventricular Arrhythmias

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