Signet-ring cell (mucin-producing) adenocarcinoma of minor salivary glands: report of a case

Bastaki, Jassem M.; Summersgill, Kurt F.

doi:10.1016/j.tripleo.2010.05.066

Cited by 18 publications

(15 citation statements)

References 3 publications

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“…A careful literature review found 12 similar tumors, all published as signet ring carcinomas [43][44][45][46]; all of these, c A mucicarmine stain demonstrates abundant intracellular mucin material. d, e Keratin cocktail and S100 immunohistochemical stains, respectively.…”

Section: Mucinous Myoepithelioma: a New Myoepithelioma Variantmentioning

confidence: 99%

Salivary Gland Tumor “Wishes” to Add to the Next WHO Tumor Classification: Sclerosing Polycystic Adenosis, Mammary Analogue Secretory Carcinoma, Cribriform Adenocarcinoma of the Tongue and Other Sites, and Mucinous Variant of Myoepithelioma

Gnepp

2014

Head and Neck Pathol

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Section: Mucinous Myoepithelioma: a New Myoepithelioma Variantmentioning

confidence: 99%

Salivary Gland Tumor “Wishes” to Add to the Next WHO Tumor Classification: Sclerosing Polycystic Adenosis, Mammary Analogue Secretory Carcinoma, Cribriform Adenocarcinoma of the Tongue and Other Sites, and Mucinous Variant of Myoepithelioma

Gnepp

2014

Head and Neck Pathol

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“…They can be observed in clusters or individual cells, indicating loss of cell cohesion. These cells are occasionally found in adenocarcinomas that accumulate mucin (Sung et al, 2008), being also reported in salivary gland adenocarcinomas (Bastaki and Summersgill, 2010), gastric neoplasia (Taniuchi et al, 2015), and ovarian cancer (Raskin and Meyer, 2010).…”

Section: Discussionmentioning

confidence: 86%

Parotid gland adenocarcinoma in a cow: case report

Queiroz

Magalhães

et al. 2018

Arq. Bras. Med. Vet. Zootec.

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A 9-year-old Girolando dairy cow, weighing 400kg, with a history of increased volume in the right parotid region, which extended to the submandibular region, was assisted. Fine needle aspiration cytology was performed, and the cytological findings were consistent with malignant neoplasm of epithelial origin (carcinoma). Because of the unfavorable prognosis, the animal was euthanized and submitted to an anatomopathological examination. Samples of the increased parotid and affected lymph nodes were collected for histopathological evaluation. The microscopic changes were accentuated features of anaplasia, moderate cell proliferation, atypical mitotic figures, and necrosis. Stroma ranged from delicate to scirrhous, and the tumor boundaries were not distinct. These findings substantiated the preliminary histomorphological diagnosis of undifferentiated carcinoma with metastasis in lymph nodes. Immunohistochemical tests were performed with anti-CK Pan (clone AE1AE3), anti-CK HMW (clone 34βE12), anti-CK19 (clone RCK108), anti-vimentin (clone V9), anti-S100 (polyclonal), and antiandrogen (polyclonal) antibodies. The immunophenotype favored the diagnosis of salivary gland adenocarcinoma. Despite the rareness in cattle, salivary gland adenocarcinoma should be considered in the differential diagnosis of diseases that occur with increased volume in the head, lymphadenopathy, drooling, dysphagia, and progressive weight loss.

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“…The remaining four cases included two in-house cases and two cases which were received for consultation. One case (Case 1) was previously reported [9], and the MASC case was previously included in the recent series [5] of this entity from our institution.…”

Section: Resultsmentioning

confidence: 99%

Secretory Myoepithelial Carcinoma: A Histologic and Molecular Survey and a Proposed Nomenclature for Mucin Producing Signet Ring Tumors

Bastaki

Purgina

Đačić

et al. 2014

Head and Neck Pathol

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Signet ring cell (mucin producing) adenocarcinoma is a rare low grade salivary gland malignancy. While currently designated as an adenocarcinoma, myoepithelial differentiation has been implied in previously reported cases. We herein perform a survey of our cases of signet ring cell adenocarcinoma and review the literature in order to refine categorization of this rare tumor. Five cases were retrieved. One was reclassified as a mammary analogue secretory carcinoma, leaving four that fulfilled the criteria for signet ring cell adenocarcinoma: the presence of prominent signet ring or vacuolated cells arranged in islands, interconnecting strands, cords or sheets in a myxoid or hyaline stroma, or pools of mucin. An extensive panel of histochemical and immunohistochemical stains and fluorescence in situ hybridization (FISH) (modeled after common phenotypes and molecular alterations seen in signet ring and myoepithelial tumors at other sites) was performed. The male-to-female ratio was 3:1. The mean age was 56 years (range 18-81). Sites involved included buccal mucosa (2), soft palate (1) and deep parotid (1). Perineural and angiolymphatic invasion were present in three and two cases respectively. One patient was lost to follow up and the remainder were alive and without disease at time of last follow up (mean 38 months). All cases showed mucicarmine positive vacuolated/signet ring cells embedded in a myxoid stroma. Three cases showed at least focal p63 staining and two cases showed positivity for calponin. Membranous E-cadherin was retained in all cases. FISH was negative for ETV6, EWSR1, and ALK1 rearrangements in all four cases. Based on the current series and the previously reported cases, it is evident that signet ring adenocarcinomas have a dual secretory and myoepithelial phenotype and thus as a whole more appropriately designated as 'secretory myoepithelial carcinoma.' They behave in a fairly indolent fashion and do not share the major molecular alterations seen in other signet ring and myoepithelial tumor types.

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Signet-ring cell (mucin-producing) adenocarcinoma of minor salivary glands: report of a case

Cited by 18 publications

References 3 publications

Salivary Gland Tumor “Wishes” to Add to the Next WHO Tumor Classification: Sclerosing Polycystic Adenosis, Mammary Analogue Secretory Carcinoma, Cribriform Adenocarcinoma of the Tongue and Other Sites, and Mucinous Variant of Myoepithelioma

Salivary Gland Tumor “Wishes” to Add to the Next WHO Tumor Classification: Sclerosing Polycystic Adenosis, Mammary Analogue Secretory Carcinoma, Cribriform Adenocarcinoma of the Tongue and Other Sites, and Mucinous Variant of Myoepithelioma

Parotid gland adenocarcinoma in a cow: case report

Secretory Myoepithelial Carcinoma: A Histologic and Molecular Survey and a Proposed Nomenclature for Mucin Producing Signet Ring Tumors

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