Signet‐ring cell gastric adenocarcinoma metastasizing into a primary cutaneous squamous cell carcinoma of the scalp

Alcaraz, Inmaculada; Santonja, Carlos; Kutzner, Heinz; Requena, Luis

doi:10.1111/j.1600-0560.2012.01928_2.x

Cited by 1 publication

(4 citation statements)

References 26 publications

(29 reference statements)

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“…The abdominal wall is often involved, typically in the umbilical and paraumbilical area (Sister Mary Joseph nodule), as well as around surgical scars. 145 The clinical presentation of these metastases can simulate inflammatory dermatoses, such as allergic contact dermatitis, erythema annulare centrifugum, or zosteriform lesions, as well as benign soft-tissue tumors and inflammatory metastatic carcinoma. 146 Histopathologically, diffuse dermal infiltration by small clusters or isolated signet-ring cells is seen (Fig.…”

Section: Metastatic Neoplasmsmentioning

confidence: 99%

“…145,147 Other visceral clear cell tumors which have been reported to metastasize to the skin include breast, lung, rectum, gallbladder, pancreas, ovary, and endometrium carcinoma. [145][146][147]…”

Section: Metastatic Neoplasmsmentioning

confidence: 99%

“…Mucin stains are positive (PAS and Alcian blue), and the neoplastic cells express CK7, CK20, CDX2, EMA, and CEA. 145,147 Other visceral clear cell tumors which have been reported to metastasize to the skin include breast, lung, rectum, gallbladder, pancreas, ovary, and endometrium carcinoma. [145][146][147]…”

Section: Metastatic Neoplasmsmentioning

confidence: 99%

“…Mucin stains are positive (PAS and Alcian blue), and the neoplastic cells express CK7, CK20, CDX2, EMA, and CEA. 145,147…”

Section: Metastatic Neoplasmsmentioning

confidence: 99%

See 3 more Smart Citations

Clear Cell Proliferations of the Skin: A Histopathologic Review

Zaballos

Lara-Valencia

Bossche³

et al. 2021

The American Journal of Dermatopathology

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Cutaneous clear cell proliferations encompass a heterogenous group of several primary cutaneous neoplasms and metastatic tumors with different histogenesis. Many of these clear cell proliferations may seem strikingly similar under the microscope resulting in challenging diagnosis. In many of these clear cell lesions, the reason for the clear or pale appearance of proliferating cells is unknown, whereas in other ones, this clear cell appearance is due to intracytoplasmic accumulation of glycogen, mucin, or lipid. Artifacts of tissue processing and degenerative phenomenon may also be responsible for the clear cell appearance of proliferating cells. Awareness of the histopathologic findings as well as histochemical and immunohistochemical techniques are crucial to the accurate diagnosis. This review details the histopathologic features of clear cell cutaneous proliferations, classifying them according their type of differentiation and paying special attention to the histopathologic differential diagnosis among them.

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Section: Metastatic Neoplasmsmentioning

confidence: 99%