Signet-ring cell carcinoma of the ampulla of Vater: a case diagnosed via repeated biopsies

Ikeda, Chisaki; Makino, Naohiko; Matsuda, Akiko; Kakizaki, Yasuharu; Ishizawa, Tetsuya; Kobayashi, Toshikatsu; Sugahara, Shinpei; Nishiduka, Mayo; Tsunoda, Michihiko; Haga, Junichiroh; Tsunoda, Rikiya; Ueno, Yoshiyuki

doi:10.1007/s12328-020-01097-5

Cited by 3 publications

(4 citation statements)

References 31 publications

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“…The lymph nodes were not CT scans revealed an enhanced area in the peri-ampullary region with marked dilatation of the CBD. A total of 13 biopsies were required to diagnose the case as SRCC [23].…”

Section: Discussionmentioning

confidence: 99%

Signet Ring Cell Carcinoma at the Ampulla of Vater: A Very Rare Diagnosis

Dawande¹,

Akhtar²,

Wankhade³

et al. 2022

Cureus

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Signet ring cell carcinoma (SRCC) is a rare lesion in the gastrointestinal tract. Further, the condition is very uncommon at the ampulla of Vater. A majority of the reported cases are typical, gland-forming adenocarcinomas. In our case, a patient aged 59 years, was diagnosed as a case of peri-ampullary carcinoma based on physical exam findings and imaging. Ultrasonography (USG) abdomen and magnetic resonance cholangiopancreatography (MRCP) revealed an enlarged common bile duct (CBD) and there was a presence of stricture at the terminal CBD. Endoscopic retrograde cholangiopancreatography (ERCP) showed growth at the ampulla of Vater. An endoscopic ultrasound guided needle core biopsy was obtained. Histopathological examination revealed the case as SRCC at the ampulla of Vater. We present this as an uncommon case of SRCC at the ampulla of Vater.

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Section: Discussionmentioning

confidence: 99%

Signet Ring Cell Carcinoma at the Ampulla of Vater: A Very Rare Diagnosis

Dawande¹,

Akhtar²,

Wankhade³

et al. 2022

Cureus

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“…Since then only 38 cases have been reported in the medical literature most of them being ages 40 and above. 2 Twenty-one of them were males and 19 females. The youngest reported was 32 years old female by Purohit et al in 2005 3 and the oldest being 82 years old female by Ushida et al 4 in 2017.…”

Section: Discussionmentioning

confidence: 99%

“…Only seven cases out of all the reported ones had Lymph node metastasis or N1 disease. 2 Patients like these have been offered adjuvant chemotherapy in some cases while some have just been observed. Being such a rare entity, there is a paucity of data on adjuvant treatment and no randomized trials to show any benefit.…”

Section: In 2017mentioning

confidence: 99%

Signet ring cell cancer of Ampulla of Vater—first ever case reported in a teenager and a review of literature

Kerawala¹,

Jamal²,

Saleem³

2021

Rare Tumors

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Ampullary cancers are rare accounting for 0.2% of all gastrointestinal cancers. Signet ring is a rare variant of adenocarcinoma, characterized by having more than 50% of mucin secreting cells and clinically having a worse prognosis. We present the case of a teenage girl with this tumor, the youngest ever reported in medical literature. An 18 years old girl with no significant past medical history presented to our clinic with symptoms of upper abdominal pain and jaundice. Her upper GI endoscopy showed an ampullary lesion which was biopsied—diagnosing it as adenocarcinoma. She underwent a pancreato-duodenectomy (Whipple’s procedure) with Child’s reconstruction and a feeding jejunostomy. Her final histopathology report was documented as infiltrating adenocarcinoma of Signet Ring variety arising from the Ampulla of Vater. Being such a rare entity, there is a lack of randomized trials advising the optimum treatment for such cases. Till then anecdotal experiences will drive the optimum management of this rare disease.

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“…Signet ring cell carcinoma (SRCC) is a malignancy that occurs in different organ systems such as the gastrointestinal tract, hepatic-pancreaticobiliary system, and urogenital system but primarily occurs in the stomach [ 7 , 8 ]. However, SRCC of the ampulla of Vater is extremely rare since only 39 cases are reported in the literature [ 9 ]. Although diagnosis is made by endoscopy and biopsy, a CT scan usually shows dilated common bile duct (CBD) without any mass, as seen in our case [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Severe Symptomatic Hypochloremia Associated with Rare Signet Ring Cell Carcinoma of the Ampulla of Vater: A Case Report

Akoum¹,

Radwan²,

Hage³

et al. 2021

Cureus

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Hypochloremia is an electrolyte disturbance characterized by low serum concentration of chloride ions, often occurring in acute illnesses and characterized by nonspecific signs and symptoms. It rarely results from decreased intake and is predominantly due to either renal or extra-renal losses. We report a case of severely worsening symptomatic hypochloremia resulting from an extra-renal loss of chloride ion in a 58-year-old female patient presenting for prolonged protracted vomiting. Chloremia reached a surprising level of 48 mEq/L, the lowest level reported in the literature. The patient was eventually diagnosed with a rare signet ring cell carcinoma that occurred in the ampulla of Vater, leading to a malignant gastric outlet obstruction and causing extra-renal loss of chloride.

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Signet-ring cell carcinoma of the ampulla of Vater: a case diagnosed via repeated biopsies

Cited by 3 publications

References 31 publications

Signet Ring Cell Carcinoma at the Ampulla of Vater: A Very Rare Diagnosis

Signet Ring Cell Carcinoma at the Ampulla of Vater: A Very Rare Diagnosis

Signet ring cell cancer of Ampulla of Vater—first ever case reported in a teenager and a review of literature

Severe Symptomatic Hypochloremia Associated with Rare Signet Ring Cell Carcinoma of the Ampulla of Vater: A Case Report

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