Signet-ring cell carcinoma of the appendix: a case report with an emphasis on sonographic findings

Cho, Young Jong; Kim, Hyuk Jung; Jang, Suk Ki; Yeon, Jae Woo; Kim, Ki Ho; Paik, So Ya

doi:10.14366/usg.15063

Cited by 5 publications

(7 citation statements)

References 11 publications

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“…Thirdly, the thickness of the appendix wall is significantly higher than that of the fat infiltration around the appendix. [22]…”

Section: Discussionmentioning

confidence: 99%

“…The pathological examination found that the appendix wall was asymmetrically thickened due to signet ring cell infiltration, and the patient underwent right hemicolectomy. [22]…”

Section: Discussionmentioning

confidence: 99%

“…Thirdly, the thickness of the appendix wall is significantly higher than that of the fat infiltration around the appendix. [22] Pathological examination is highly essential for a definite diagnosis. Microscopic characteristics of SRCC includes a large number of abnormally proliferative cells evolving into appendiceal tissues with a diffuse distribution.…”

Section: Discussionmentioning

confidence: 99%

“…The pathological examination found that the appendix wall was asymmetrically thickened due to signet ring cell infiltration, and the patient underwent right hemicolectomy. [22] Tumor reduction surgery and intraperitoneal thermochemotherapy (CRS/HIPEC) are considered as the standard treatment for peritoneal dissemination of appendiceal cancer. [1] An aggressive approach to these patients that includes CRS/HIPEC is advocated because of the possibility of long-term relapse-free survival (and possibly cure) in a subset of patients.…”

Section: Discussionmentioning

confidence: 99%

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Clinical benefits of FOLFOXIRI combined with bevacizumab for advanced-stage primary signet ring cell carcinoma of the appendix: A case report

Huang

Wang

et al. 2023

Medicine

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Rationale: Signet-ring cell carcinoma, which is an infrequent type of colorectal cancer. Abdominal pain is the primary presenting complaint of patients with acute appendicitis. It is difficult to diagnose patients with appendiceal carcinomas accompanying with symptoms of acute appendicitis. Patient Concerns: A 33-year-old female patient was admitted to our hospital, with chief complaints of “bilateral pelvic space-occupying lesions for 1 month, aggravated abdominal distension, and she accompanied with diarrhea for 3 days.” Diagnosis: The patient was with primary signet ring cell carcinoma of the appendix, presented with acute appendicitis, as well as bilateral ovarian metastasis and peritoneal implantation metastasis. Interventions: She was then treated with irinotecan, oxaliplatin, calcium folinate, 5-FU combined with bevacizumab, surgical treatment, and postoperative adjuvant treatment with oxaliplatin, capecitabine regimen to consolidate the efficacy. Outcomes: The patient is in good conditions, and postoperative adjuvant chemotherapy is in progress as well. Conclusion: The outcomes highlighted the importance of strict histopathologic assessment for appendiceal adenocarcinoma, and provided new ideas for the diagnosis and treatment of advanced-stage signet ring cell carcinoma of the appendix.

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“…Thirdly, the thickness of the appendix wall is significantly higher than that of the fat infiltration around the appendix. [22]…”

Section: Discussionmentioning

confidence: 99%

“…The pathological examination found that the appendix wall was asymmetrically thickened due to signet ring cell infiltration, and the patient underwent right hemicolectomy. [22]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical benefits of FOLFOXIRI combined with bevacizumab for advanced-stage primary signet ring cell carcinoma of the appendix: A case report

Huang

Wang

et al. 2023

Medicine

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“…Among the current case samples, one case has been reported in a case report that described the sonographic findings of signet-ring cell carcinoma (Case 7) in the appendix. [ 11 ]…”

Section: Ase R Eportmentioning

confidence: 99%

Sonographic findings of malignant appendix tumors in seven cases

et al. 2018

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We report the sonographic features of confirmed malignant appendiceal tumors in seven cases. The histologic diagnoses of these tumors were mucinous cystadenocarcinoma (n = 2), colonic type adenocarcinoma (n = 4), and signet-ring cell carcinoma (n = 1). The 2 mucinous cystadenocarcinomas showed mucocele type, which had markedly enlarged inner luminal diameters (mean, 23 mm; range, 15–31 mm) and thick, irregular walls (mean wall thickness, 5.5 mm; range, 5–6 mm). In contrast, the 5 nonmucinous carcinomas (4 adenocarcinomas and 1 signet-ring cell carcinoma) showed nonmucocele type, which had relatively small inner luminal diameters (mean ± standard deviation [SD], 6.6 ± 4.5 mm; range, 2–15 mm) and prominent wall thickening (mean wall thickness ± SD, 6.2 ± 2.3 mm; range, 3–10 mm). Of the 5 nonmucinous tumors, only one had a discernible mass, three had thick irregular walls, two had loss of the wall layer pattern, and four had submucosal hypoechogenicity. Regardless of the histologic type, five of the seven malignant appendiceal tumors showed a severe periappendiceal fat infiltration or periappendiceal abscess, suggestive of perforation. Although the sonographic findings of the malignant appendiceal tumors were nonspecific, some of the sonographic features seen in these seven cases may help radiologists consider the possibility of underlying malignant appendiceal tumors.

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Appendiceal Signet Ring Cell Carcinoma: An Atypical Cause of Acute Appendicitis—A Case Study and Review of Current Knowledge

et al. 2023

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Appendiceal signet ring cell carcinoma (ASRCC) is a rare and aggressive form of appendiceal cancer, often presenting with nonspecific symptoms that overlap with acute appendicitis. Early diagnosis and appropriate management are crucial for improving patient outcomes in these rare malignancies. This case report and literature review aims to raise awareness among clinicians about ASRCC of the appendix as a cause of acute appendicitis and highlight the importance of considering this diagnosis in patients with atypical presentations or unexpected histopathological findings. We present a 65-year-old female patient with ASRCC who underwent successful surgical treatment and remains disease-free at the one-year follow-up. It also highlights the necessity of early detection and appropriate treatment in order to improve patient outcomes. In addition, a comprehensive literature review is provided, discussing the clinical presentation, histopathological characteristics, potential pathogenesis, treatment options, and prognosis of ASRCC.

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Signet-ring cell carcinoma of the appendix: a case report with an emphasis on sonographic findings

Cited by 5 publications

References 11 publications

Clinical benefits of FOLFOXIRI combined with bevacizumab for advanced-stage primary signet ring cell carcinoma of the appendix: A case report

Clinical benefits of FOLFOXIRI combined with bevacizumab for advanced-stage primary signet ring cell carcinoma of the appendix: A case report

Sonographic findings of malignant appendix tumors in seven cases

Appendiceal Signet Ring Cell Carcinoma: An Atypical Cause of Acute Appendicitis—A Case Study and Review of Current Knowledge

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