Signet ring cell carcinoma of the gastrointestinal tract: National trends on treatment effects and prognostic outcomes

Franko, Jan; Le, Viet Ha; Tee, May C.; Lin, Ming V.; Sedinkin, Jessica; Raman, Shankar; Franková, Daniela

doi:10.1016/j.ctarc.2021.100475

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…According to our study, gastric SRCC exhibits different clinicopathological features compared with other types of gastric adenocarcinoma; for example, it occurs more frequently in females and develops at a relatively younger age. This finding was similar to related reports from previous studies[ 15 , 16 ], although the exact cause was not yet clear. It has been proposed that the cancerization of SRCC might be influenced by sex hormones, especially estrogen receptor (ER).…”

Section: Discussionsupporting

confidence: 91%

“…Several studies have suggested that gastric SRCC has a better prognosis than other types of gastric adenocarcinoma at an early stage, but the survival outcome of patients with advanced-stage disease is still controversial[ 16 , 20 - 23 ]. According to our present analysis of the prognosis of 83 SRCC patients, the 3-year CSS rate was 73.7%, and that of patients with advanced-stage disease was 63.7%.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma

Lin,

Chen,

Guo

et al. 2024

World J Gastrointest Oncol

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BACKGROUND The Alcian blue (AB) and periodic acid Schiff (PAS) stains are representative mucus markers in gastric signet ring cell carcinoma (SRCC). They are low-cost special staining methods used to detect acidic mucus and neutral mucus, respectively. However, the clinical importance of the special combined AB and PAS stain is unclear. AIM To investigate AB expression, PAS expression and the AB-to-PAS (A/P) ratio in gastric SRCC patients and to assess patient prognosis. METHODS Paraffin-embedded sections from 83 patients with gastric SRCC were stained with AB and PAS, and signet ring cell positivity was assessed quantitatively. Immunohistochemical staining for Ki67, protein 53 (P53) and human epidermal growth factor receptor 2 (HER2) was performed simultaneously. The cancer-specific survival (CSS) rate was estimated via Kaplan-Meier analysis. Cox proportional hazards models were used for univariate and multivariate survival analyses. RESULTS Kaplan-Meier survival analysis revealed that the 3-year CSS rate was significantly greater in the high-PAS-expression subgroup than in the low-PAS-expression subgroup (P < 0.001). The 3-year CSS rate in the A/P ≤ 0.5 group was significantly greater than that in the A/P > 0.5 group (P = 0.042). Univariate Cox regression analysis revealed that the factors affecting prognosis included tumor diameter, lymph node metastasis, vessel carcinoma embolus, tumor stage, the A/P ratio and the expression of Ki67, P53 and the PAS. Cox multivariate regression analysis confirmed that low PAS expression [hazard ratio (HR) = 3.809, 95% confidence interval (CI): 1.563-9.283, P = 0.003] and large tumor diameter (HR = 2.761, 95%CI: 1.086-7.020, P = 0.033) were independent risk factors for poor prognosis. CONCLUSION A/P > 0.5 is potentially a risk factor for prognosis, and low PAS expression is an independent risk factor in the prognosis of gastric SRCC. PAS expression and the A/P ratio could help in predicting the clinical prognosis of patients with SRCC.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma

Lin,

Chen,

Guo

et al. 2024

World J Gastrointest Oncol

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“…Signet ring cell carcinoma always lead to poor prognosis [27], which was not obtained in our study since this pathological type accounted for only 2.9%.…”

Section: Discussioncontrasting

confidence: 78%

Clinicopathological characteristics and prognostic factors of elderly small bowel adenocarcinoma using propensity score matching analysis: A study based on SEER database

Liu

xie

Yang

et al. 2022

Preprint

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Background Small intestine adenocarcinoma is a scant disease which has no adequate clinic trials, so its prognostic factors are still unclear especially in elderly patients. In this article, We aimed to explore the clinicopathology presentation, treatments, outcomes and predictors of small intestine adenocarcinoma patients who aged 65 years or older. Methods We retrieved clinicopathology data of small intestine adenocarcinoma patients diagnosed between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. we clarified patients into two groups: surgery and non-surgery group, and conducted propensity score matching (PSM) to compare survival outcoming. We identified the prognostic indicators for cancer-specific survival (CSS) and overall survival (OS) by Cox proportional hazards model. Results In total, 1018 eligible cases were enrolled, with a median survival of 16 months, the 3-year OS and CSS rates was 36% and 41.7%, and the 5-year OS and CSS rates was 26.5% and 33.3%. Multivariate analyses revealed that age, grade, tumor stage, surgery and chemotherapy were independent prognostic factors for OS, while grade, tumor stage, surgery, radiation and chemotherapy were independent factors for CSS. After PSM, only surgery and tumor stage(AJCC 6th) were independent prognostic factors for OS and CSS. Conclusion Surgery could bring benefit to survival for elderly SBA patients, and early stage of disease was another significant prognostic factor.

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“…However, there are important molecular differences described between the two entities that explain the lower rates of response and survival in the appendiceal cancer population [ 2 ]. The latter also has higher rates of signet ring cells (SRC) subtype that are associated with ominous prognosis in any primary [ 33 ]. In spite of the absence of specific chemotherapy protocols, it has been shown that patients with mucinous adenocarcinoma (MAC), non-mucinous adenocarcinoma (NMAC) and SRC all benefit from adjuvant chemotherapy, while there is little data about the results of induction treatment [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…The potential role of neoadjuvant intraperitoneal chemotherapy was already emphasized in other appendiceal entities (pseudomyxoma) [ 38 ]. The probable effectiveness of other types of intraperitoneal administrations in the context of peritoneal disease of appendiceal origin adds to the rationale of PIPAC, in spite of the clinical setting of the present study that is limited to appendiceal adenocarcinoma [ 12 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Treatment Response after Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) for Appendiceal Peritoneal Metastases

Somashekhar

Abba

Sgarbură

et al. 2022

Cancers

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Background The aim of this study was to analyse survival and surrogates for oncological response after PIPAC for appendiceal tumours. Methods This retrospective cohort study included consecutive patients with appendiceal peritoneal metastases (PM) treated in experienced PIPAC centers. Primary outcome measure was overall survival (OS) from the date of diagnosis of PM and from the start of PIPAC. Predefined secondary outcome included radiological response (RECIST criteria), repeat laparoscopy and peritoneal cancer index (PCI), histological response assessed by the Peritoneal regression grading system (PRGS) and clinical response. Results Final analysis included 77 consecutive patients (208 PIPAC procedures) from 15 centres. Median OS was 30 months (23.00–46.00) from time of diagnosis and 19 months (13.00–28.00) from start of PIPAC. 35/77 patients (45%) had ≥3 procedures (pp: per protocol). Objective response at PIPAC3 was as follows: RECIST: complete response 4 (11.4%), 11 (31.4%) partial/stable; mean PRGS at PIPAC3: 1.8 ± 0.9. Median PCI: 21 (IQR 18–27) vs. 22 (IQR 17–28) at baseline (p = 0.59); 21 (60%) and 18 (51%) patients were symptomatic at baseline and PIPAC3, respectively (p = 0.873). Median OS in the pp cohort was 22.00 months (19.00-NA) from 1st PIPAC. Conclusion Patients with PM of appendiceal origin had objective treatment response after PIPAC and encouraging survival curves call for further prospective evaluation.

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Signet ring cell carcinoma of the gastrointestinal tract: National trends on treatment effects and prognostic outcomes

Cited by 7 publications

References 32 publications

Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma

Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma

Clinicopathological characteristics and prognostic factors of elderly small bowel adenocarcinoma using propensity score matching analysis: A study based on SEER database

Assessment of Treatment Response after Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) for Appendiceal Peritoneal Metastases

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