Signet-ring cell carcinoma of ampulla of Vater: Contrast-enhanced ultrasound findings

Abstract

Signet-ring cell carcinoma (SRCC) of ampulla of Vater is extremely uncommon, and less than 15 cases have been reported so far in literature. It mainly occurs in elderly people (median age 57 years). We report a rare case of SRCC of the ampulla of Vater in a 38-year-old woman who presented with a small tumor at the Vater, discovered by the contrast-enhanced ultrasound (CEUS). Histopathological examination showed prominent signet-ring features. We also describe the imaging features of SRCC of ampulla of Vater in CEUS.

Signet Ring Cell Carcinoma of the Ampulla of Vater With Leptomeningeal Metastases: A Case Report

“…11 Little is known about this tumor's natural history and prognosis. 5,7,8,[10][11][12][16][17][18] The role of adjuvant chemotherapy in this tumor is uncertain. Six cases presented with T2N0M0 disease (invading the duodenal wall), 5,8,11,12,16,17 and two cases presented with metastatic disease.…”

Signet Ring Cell Carcinoma of the Ampulla of Vater with Early Development of Bone Metastasis: Case Report and Review of the Rare Malignancy

“…Distant metastases appear to be associated with a short life expectancy after surgery. Acharya [3] 78/F T3N0M0 Pancreatoduodenectomy -Alive at 6 months Akatsu [4] 43/F T2N0M0 Pancreatoduodenectomy -Alive at 7.5 years Bloomston [5] 58/F T2N0M0 Pancreatoduodenectomy -Alive at 11 years Dauodi [6] 55/M T3N0M0 Pancreatoduodenectomy Chemotherapy Alive at 8 months Erquchi [7] 83/M T3N0M0 Pancreatoduodenectomy -Alive at 18 months Fang [8] 53/M T2N0M0 Pancreatoduodenectomy -Alive at 2 years Gao [9] 38/F T3N0M0 Pancreatoduodenectomy -Alive at 6 months Garcia [10] 73/M T2N1M0 Pancreatoduodenectomy -Alive at 14 months Garcia [10] 74/M T3N0MX Total pancreatectomy -Alive at 3 months Gardner [2] 69/F T3N0M0 Pancreatoduodenectomy -Unknown Gheza [11] 66/M Unknown Pancreatoduodenectomy -Alive at 8 months Hara [12] 68/M T2N0M0 Pancreatoduodenectomy -Alive at 10 months Ishibashi [13] 59/M T3N0M0 Pancreatoduodenectomy -Alive at 1.5 years Kim [14] 4 7 / M T X N 1 M X -Chemotherapy Died at 15 months Lesquereux-Martinez [15] 78/F TXN1M0 Pancreatoduodenectomy Chemotherapy Alive at 14 months Li [16] 56/F T2N1M0 Pancreatoduodenectomy -Alive at 12 months Maekawa [17] 75/M T3N0M0 Pancreatoduodenectomy -Died at 6 months Nabeshima [18] 49/M T3NXM1 -Chemotherapy Died at 12 months Paplomata [19] 45/F T4N1MX Pancreatoduodenectomy Chemotherapy Died at 12 months Purohit [20] 32/F TXNXM1 Declined Declined Unknown Ramia [21] 67/F T2N0M0 Pancreatoduodenectomy -Alive at 12 months Sekoguchi [22] 47/M T3N0M0 --Unknown Tas [23] 4 0 / M T X N 1 M 1 --Unknown Terada [24] 74/F TXNXM0 Biliary stent Chemotherapy Died at 14 months Tseng [25] 47/M T3N0M0 Pancreatoduodenectomy -Alive at 6 months Valeri [26] 66/M Unknown Pancreatoduodenectomy -Alive at 6 months Wen [27] 40/F T3N0M0 Pancreatoduodenectomy Chemotherapy Alive at 8 months Wen [27] 64/F T4NXM0 Pancreatoduodenectomy -Alive at 6 years Wen [27] 75/F T4NXM0 Pancreatoduodenectomy Chemoradiation Died at 16 months Wen [...…”

Carcinoma de células en anillo de sello de la ampolla de Vater

“…Fue descrito por primera vez por Sekoguchi 1 y, actualmente, hay menos de 20 casos referidos en la literatura (tabla 1) [8][9][10][11][12][13][14][15][16][17][18][19] . La edad media al diagnóstico de los casos precedentes es de 55,5 años (rango 32-83años) unos 15 años por encima de la edad media del CCAS gástrico y similar a la edad media del CCAS del intestino delgado y menor que la de los ampulomas en general 3 .…”

“…El diagnóstico de sospecha se establece mediante una técnica de imagen (ecografía abdominal, colangioresonancia magnética, TC o ultrasonografía endoscópica) 18 y debe confirmarse histológicamente, habitualmente mediante biopsias en una duodenoscopia. En ocasiones, es precisa la colocación de una prótesis de drenaje biliar durante la realización de una CPRE.…”