Signet ring cell carcinoma of rectum metastasizing to synchronous renal cell carcinoma: a case report

Abstract

Background Rectal signet ring cell carcinoma is a rare type of colorectal adenocarcinoma characterized by an aggressive biological behavior and poor prognosis. The co-occurrence of colorectal carcinoma and renal cell carcinoma (RCC) has found in many hundreds of patients, many of whom also have additional malignancies. Cancer to cancer metastasis is rare and an uncommon phenomenon in malignancy, especially at the time of initial diagnosis, suggesting a genetic susceptibility. Case presentation We present the case of a 66-year-old Macedonian man with synchronous rectal signet ring cell carcinoma and RCC with tumor to tumor metastasis feature. He underwent a left nephrectomy and anterior rectal resection after complaining of constipation for 3–4 months and the appearance of synchronous tumors on the imaging studies. Morphology and immunohistochemical analysis of specimens from the RCC revealed signet ring cells identical to the rectal signet ring cell carcinoma. The next-generation sequencing study revealed mutations in TP53 and ERBB2, and microsatellite stable signet ring cell carcinoma was determined by deoxyribonucleic acid (DNA) sequencing. Conclusions Cancer to cancer metastasis, although rare, needs to be considered in synchronous tumors. RCC, when diagnosed in multiple synchronous tumors, should be examined carefully. The paucity of reported cases indicates the need for advanced research in imaging methods for metastasis and new therapeutic approaches.

Metastasis of Rectal Signet Ring Cell Carcinoma to Typical Lipoma: A Rare Presentation of the Tumor-to-Tumor Metastasis Phenomenon

“… 10 In 2021, Krsteska reported a case of a 66-year-old Macedonian man with rectal SRCC of rectum metastasizing to synchronous renal cell carcinoma and to the adrenal gland and treated with a left nephrectomy and anterior rectal resection. 4 …”

“…It represents a sign of poor prognosis and reflects the dissemination of the disease. 4 Herein, we present a case of a colorectal signet cell carcinoma with the fortuitous discovery of a metastatic localization within a resected lipoma of the anterior abdominal wall. To the best of our knowledge, this represents the inaugural instance documented in the literature involving this specific pairing of a donor and a host tumor, and marks the initial occurrence of metastasis in a typical lipoma.…”

Tumor-to-Tumor Metastasis of Lung Cancer to Kidney Cancer: A Review of the Literature and Our Experience

“…However, TTM is not as rare as previously thought. Since Berent’s original case report in 1902, almost 200 cases have been reported in the literature [ 8 , 9 , 10 , 11 , 12 ]. The most frequently reported recipient tumor is RCC, and lung carcinomas are the most common metastatic tumor donors.…”

An Extremely Rare Case of Rectal Signet Ring Cell Carcinoma

“…A majority of CRCs are adenocarcinomas which can be further differentiated in mucinous, signet ring cell, and other less common subtypes [ 1 ]. Signet ring cell carcinoma (SRCC) is defined by the presence of greater than 50% extracellular mucin by volume with the stomach being the most common site [ 2 , 3 ]. Signet ring cell morphology is a rare pathological finding for CRC, making up less than 1% of CRCs and about 1.39% of rectal cancers [ 4 , 5 ].…”