Signet ring cell carcinoma in a juvenile polyp

Lucas, Carmen Villar; Martín, Maikal Villena; Álvarez-Cuenllas, Begoña

doi:10.17235/reed.2019.6299/2019

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Intramucosal carcinoma arising within a solitary juvenile polyp was regarded as 'a wolf in sheep's clothing' 16,21 . Other researchers 10,22,23 have reported three cases of signet ring cell carcinoma in juvenile polyps. In our study, one juvenile polyp with focal carcinogenesis and 7 with low-grade intraepithelial neoplasia were identi ed.…”

Section: Discussionmentioning

confidence: 95%

Characteristics and potential malignancy of colorectal juvenile polyps in adults: a single-center retrospective study in China

Dong

Chen

et al. 2021

Preprint

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BackgroundColorectal juvenile polyps are rare and usually considered benign in adults. Carcinogenesis or neoplastic changes are rarely mentioned in the literature. We aimed to systematically evaluate the characteristics and potential malignancy of colorectal juvenile polyps in adults.MethodsWe retrospectively reviewed the medical records of 103 adults diagnosed with colorectal juvenile polyps from 9/2007 to 5/2020 in our hospital. The characteristics, endoscopic findings, occurrence of intraepithelial neoplasia, carcinogenesis and diagnostic value of chicken skin mucosa (CSM) were analyzed.ResultsThe average age of patients with juvenile polyps was 43.2 years (range, 19 to 78). A total of 101 patients (101/103, 98.1%) had a single juvenile polyp, while two had multiple polyps (107 polyps in total). Polyp sizes ranged from 0.5 to 5 cm. One (1/107, 0.9%) juvenile polyp was cancerous, and 7 (7/107, 6.5%) developed low-grade intraepithelial neoplasia. Neoplasia or cancerization was not associated with the number of polyps. A 27-year-old female had a polyp with well-differentiated adenocarcinoma in the mucosa that was 2 cm in the sigmoid colon with erosion on the surface. According to immunohistochemistry, the Ki-67 was approximately 80%. P53 was mutated with diffuse and strongly positive expression. CSM was observed beside 17 polyps, which were all located in the rectum and sigmoid colon; one polyp had low-grade intraepithelial neoplasia.ConclusionsColorectal juvenile polyps in adults have neoplastic potential. Neither neoplasia nor carcinogenesis was associated with the number of polyps. CSM was not a tumorigenesis marker in colorectal juvenile polyps in the distant colorectum. Colorectal juvenile polyps in adult may go through a ‘low-grade intraepithelial neoplasia to high-grade intraepithelial neoplasia to carcinoma’ path and should be treated and regularly followed up as adenomas.

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Section: Discussionmentioning

confidence: 95%

Characteristics and potential malignancy of colorectal juvenile polyps in adults: a single-center retrospective study in China

Dong

Chen

et al. 2021

Preprint

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“…Intramucosal carcinoma arising within a solitary juvenile polyp is regarded as ‘a wolf in sheep’s clothing’ [ 17 , 22 ]. Other researchers [ 10 , 23 , 24 ] reported three cases of signet ring cell carcinoma in juvenile polyps. One (0.9%) juvenile polyp with focal carcinogenesis and seven (6.5%) polyps with low-grade intraepithelial neoplasia were identified in our study.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and potential malignancy of colorectal juvenile polyps in adults: a single-center retrospective study in China

Dong

Chen

et al. 2022

BMC Gastroenterol

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Background Colorectal juvenile polyps are rare and generally considered benign in adults. Carcinogenesis or neoplastic changes are rarely mentioned in the literature. We systematically evaluated the characteristics and potential malignancy of colorectal juvenile polyps in adults. Methods We retrospectively reviewed the medical records of 103 adults diagnosed with colorectal juvenile polyps from September 2007 to May 2020 at our hospital. The characteristics, endoscopic findings, occurrence of intraepithelial neoplasia, carcinogenesis and diagnostic value of chicken skin mucosa (CSM) were analyzed. Results The average age of patients with juvenile polyps was 43.2 years (range, 19 to 78 years). A total of 101 patients (101/103, 98.1%) had a single juvenile polyp, and two patients had multiple polyps (107 polyps in total). Polyp sizes ranged from 0.5 to 5 cm. One (1/107, 0.9%) juvenile polyp was cancerous, and 7 (7/107, 6.5%) developed low-grade intraepithelial neoplasia. Neoplasia and cancerization did not appear in the two patients with multiple polyps. A 27-year-old female had a 2-cm polyp with well-differentiated adenocarcinoma in the mucosa in the sigmoid colon with erosion on the surface. CSM was observed adjacent to 17 polyps, which were all located in the rectum and sigmoid colon, and one polyp showed low-grade intraepithelial neoplasia. Conclusions Colorectal juvenile polyps occur in a wide range of locations and in variable sizes and numbers. These polyps are solitary in most patients and have neoplastic potential. CSM is not a tumorigenic marker in colorectal juvenile polyps and usually occurs in the distant colorectum. Colorectal juvenile polyps in adults may progress from low-grade intraepithelial neoplasia to high-grade intraepithelial neoplasia and then to carcinoma and should be treated when discovered and regularly followed as colorectal adenomas.

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