Signatures of positive selection for local adaptation of African native cattle populations: A review

AYALEW, Wondossen; Wu, Xiaoyun; Tarekegn, Getinet Mekuriaw; Chen, Min; Liang, Chunnian; Tessema, Tesfaye Sisay; Yan, Ping

doi:10.1016/j.jia.2023.01.004

Cited by 5 publications

(4 citation statements)

References 101 publications

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“…Although the content is rich in cattle genetic resources, limited studies have been conducted on the adaptive attributes of African cattle breeds [5,6,8,9]. This highlights the need for further research into the distinctive genetic factors that underlie adaptive traits within unexplored individual cattle breeds [10,11].…”

Section: Introductionmentioning

confidence: 99%

Whole-Genome Resequencing Reveals Selection Signatures of Abigar Cattle for Local Adaptation

Ayalew,

Wu,

Tarekegn

et al. 2023

Animals

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Over time, indigenous cattle breeds have developed disease resistance, heat tolerance, and adaptability to harsh environments. Deciphering the genetic mechanisms underlying adaptive traits is crucial for their improvement and sustainable utilization. For the first time, we performed whole-genome sequencing to unveil the genomic diversity, population structure, and selection signatures of Abigar cattle living in a tropical environment. The population structure analysis revealed that Abigar cattle exhibit high nucleotide diversity and heterozygosity, with low runs of homozygosity and linkage disequilibrium, suggesting a genetic landscape less constrained by inbreeding and enriched by diversity. Using nucleotide diversity (Pi) and population differentiation (FST) selection scan methods, we identified 83 shared genes that are likely associated with tropical adaption. The functional annotation analysis revealed that some of these genes are potentially linked to heat tolerance (HOXC13, DNAJC18, and RXFP2), immune response (IRAK3, MZB1, and STING1), and oxidative stress response (SLC23A1). Given the wider spreading impacts of climate change on cattle production, understanding the genetic mechanisms of adaptation of local breeds becomes crucial to better respond to climate and environmental changes. In this context, our finding establishes a foundation for further research into the mechanisms underpinning cattle adaptation to tropical environments.

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Section: Introductionmentioning

confidence: 99%

Whole-Genome Resequencing Reveals Selection Signatures of Abigar Cattle for Local Adaptation

Ayalew,

Wu,

Tarekegn

et al. 2023

Animals

Self Cite

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“…The farmers that receive these animals also become highly stressed. 2 The solution is return the focus to indigenous genotypes that can already cope with local conditions and improve productivity by carefully planned use of reproductive technology and genetic and genomic tools (39,40). The simplicity of this approach is demonstrated by the introduction of Holstein genes to improve milk production in Sanga cattle in Ghana (41).…”

Section: 'Green' -Environmental Footprintmentioning

confidence: 99%

Perspective: science and the future of livestock industries

Martin

2024

Front. Vet. Sci.

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Since the 1990s, livestock industries have been forced to respond to major pressures from society, particularly with respect to methane emissions and animal welfare. These challenges are exacerbated by the inevitability of global heating and the effects it will have on livestock productivity. The same challenges also led to questions about the value of animal-sourced foods for feeding the world. The industries and the research communities supporting them are meeting those challenges. For example, we can now envisage solutions to the ruminant methane problem and those solutions will also improve the efficiency of meat and milk production. Animal welfare is a complex mix of health, nutrition and management. With respect to health, the ‘One Health’ concept is offering better perspectives, and major diseases, such as helminth infection, compounded by resistance against medication, are being resolved through genetic selection. With respect to nutrition and stress, ‘fetal programming’ and the epigenetic mechanisms involved offer novel possibilities for improving productivity. Stress needs to be minimized, including stress caused by extreme weather events, and solutions are emerging through technology that reveals when animals are stressed, and through an understanding of the genes that control susceptibility to stress. Indeed, discoveries in the molecular biology of physiological processes will greatly accelerate genetic progress by contributing to genomic solutions. Overall, the global context is clear – animal-sourced food is an important contributor to the future of humanity, but the responses of livestock industries must involve local actions that are relevant to geographical and socio-economic constraints.

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“…Over 80% of TSZ cattle are kept by smallholder farmers under the agro-pastoral production system [5,[6][7]. Despite their low production coefficients, they have been serving commendably as a source of income, food, draught power, transport, hides and manure [5,[7][8]. Further, they act as a form of insurance and accumulation of wealth.…”

Section: Introductionmentioning

confidence: 99%

“…Determining whether or not a non-descript population is distinguishable from neighbouring ones on the basis of identifiable and stable phenotypic characteristics, that might warrant it being distinguished as a separate population is one of the roles of phenotypic characterization [13]. However, large proportion of indigenous cattle populations of the African continent, which harbors an important part of global cattle genetic resources are yet to be described [8,16]. This applies to TSZ breed as some of its subpopulations are still non-descript in certain locations [17].…”

Section: Introductionmentioning

confidence: 99%

Colour and Morphometric Characteristics of Ukerewe and Bunda Indigenous Cattle Populations in the Lake Victoria Basin, Tanzania

Chasama,

Chang’a

2023

AJRAVS

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This study was undertaken with the objective of comparing body colour and morphometric characteristics of indigenous cattle populations in Ukerewe and Bunda Districts located in the Lake Victoria basin area of Tanzania. A total of 169 adult cattle selected randomly from the study area were examined for colour and morphometric characteristics and then taken linear body measurements. Majority of the cattle had plain colour pattern (63.8% in Ukerewe and 67.4% in Bunda). Predominant coat colour in Ukerewe and Bunda Districts were black and brown, respectively. A considerable proportion of cattle in this study had small sized dewlaps and navel flaps. Ukerewe cattle population had significantly (P < 0.05) bigger heart girths and very highly significantly (P < 0.001) shorter horns than Bunda cattle. The rest of the physical body measurements and all external body appendages showed insignificant (P > 0.05) differences between the two strains. With the exception of ear length and muzzle circumference, all

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Signatures of positive selection for local adaptation of African native cattle populations: A review

Cited by 5 publications

References 101 publications

Whole-Genome Resequencing Reveals Selection Signatures of Abigar Cattle for Local Adaptation

Whole-Genome Resequencing Reveals Selection Signatures of Abigar Cattle for Local Adaptation

Perspective: science and the future of livestock industries

Colour and Morphometric Characteristics of Ukerewe and Bunda Indigenous Cattle Populations in the Lake Victoria Basin, Tanzania

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