Abstract:Coronaviruses are a significant threat to public health, animal welfare, and economic stability. SARS-CoV-2 and seasonal coronaviruses continue to cause disease and coronaviruses in the animal reservoir pose a constant spillover threat. Immunological imprinting is a term meant to represent the strong influence of the first viral infection on the outcome of subsequent related viral infections or vaccination, with “Original Antigenic Sin” having historically been applied to the potential negative effects of such… Show more
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