Signatures of immune cell infiltration for predicting immune escape and immunotherapy in cervical cancer

Abstract

The cervical cancer tumor microenvironment is a diverse and complex ecosystem. Tumor-immune cell infiltration (ICI) may influence immune escape and immunotherapeutic responses. However, the relationship between immune cell infiltrations, immune escape, and immunotherapy in cervical cancer has not been fully clarified. Here, Principal component analysis (PCA) and Tumor immune dysfunction and exclusion (TIDE) were applied to calculate individual ICI scores and probabilities of immune escape, respectively. Through the IMvigor210 and the Cancer Immunome Atlas (TCIA) datasets, we validated the different responses to immunotherapy in two subgroups of patients. Furthermore, therapeutic benefits of different patients were predicted by the pRRophetic package. We found that patients with high ICI scores were prone to immune escape due to the activated JAK-STAT signaling pathway, along with lower CD8+ T cells. High ICI scores patients could benefit more from anti-PD-L1 immunotherapy, and individuals with low scores may be better candidates for the anti-CTLA-4 treatment. Combinations of immunotherapies with targeted inhibitors may improve clinical efficacy and reduce the risk of tumor recurrence. The ICI model not only helps us enhance the cognition of immune escape, but also guides the application of immunotherapy in cervical cancer patients.

Pan-cancer analyses reveal genomics and clinical outcome association of the fatty acid oxidation regulators in cancer

“…As described by previous studies, the results of immunotherapy were affected by the level of immune infiltration [ 14 ]. Therefore, we further assessed the prognosis value of FAO in immune therapy.…”

HIF-1A as a prognostic biomarker related to invasion, migration and immunosuppression of cervical cancer

“…The infiltration of immune cells is significantly related to the pathogenesis of cervical cancer [ 23 ]. By analyzing the TCGA dataset, we identified the infiltration of follicular helper T cells, natural killer cells, CD8 + T cells, mast cells, and Tregs associated with HIF-1A in cervical cancer.…”

USF1 regulated circPRDM4 modulates tumorigenesis and immune escape in chemoresistant cervical cancer

“…1,5 The intricate mechanism responsible for the inherent system, suggesting that tumours possess mechanisms to evade immune surveillance. [21][22][23] Previous study has demonstrated that circPRDM4 participates in immune escape in hepatocellular carcinoma. 16 Thereafter, the role of circPRDM4 in the immune response of DDP-resistant CC cells was also explored for a better understanding of the phenomena of circPRDM4 on CC chemoresistance.…”

“…Cellular immunity, particularly involving T lymphocytes, dendritic cells, natural killer cells and macrophages, plays a crucial role in anti‐tumour immune responses. Nevertheless, tumours can persist and metastasize despite the presence of a functioning immune system, suggesting that tumours possess mechanisms to evade immune surveillance 21–23 . Previous study has demonstrated that circPRDM4 participates in immune escape in hepatocellular carcinoma 16 .…”