Signatures of CD4+ T and B cells are associated with distinct stages of chronic chagasic cardiomyopathy
Isabela Natália Pascoal Campos do Vale,
Gregório Guilherme Almeida,
Inga Rimkute
et al.
Abstract:IntroductionChagas disease is a neglected parasitic disease caused by Trypanosoma cruzi. While most patients are asymptomatic, around 30% develop Chronic Chagasic Cardiomyopathy (CCC).MethodsHere, we employed high-dimensional flow cytometry to analyze CD4+ T and B cell compartments in patients during the chronic phase of Chagas disease, presenting the asymptomatic and mild or moderate/severe cardiac clinical forms.ResultsEffector CD27-CD4+ T cells were expanded in both CCC groups, and only mild CCC patients sh… Show more
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