Signature genomic traits of the core and accessory genome of Vibrio Cholerae O1 drive lineage transmission and disease severity
Alexandre Maciel-Guerra,
Kubra Babaarslan,
Michelle Baker
et al.
Abstract:In Bangladesh, Vibrio cholerae lineages are undergoing genomic evolution, causing pandemics and outbreaks with increased virulence, resistance, spreading ability and disease severity. However, our understanding of the genomic determinants influencing transmission and disease severity patterns, as well as their interplay, remains incomplete. Here, we developed a computational framework based on machine-learning, genome scale metabolic modelling (GSSM) and 3D structural analysis, to identify V. cholerae signatur… Show more
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